다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Molecules a journal of synthetic chemistry and natural product chemistry, v.19 no.3, 2014년, pp.3654 - 3668
Xia, Ning , Pautz, Andrea , Wollscheid, Ursula , Reifenberg, Gisela , Förstermann, Ulrich , Li, Huige
AI-Helper
Artichoke (Cynara scolymus L.) is one of the world’s oldest medicinal plants with multiple health benefits. We have previously shown that artichoke leaf extracts and artichoke flavonoids upregulate the gene expression of endothelial-type nitric oxide synthase (eNOS) in human endothelial cells. Where...
1. Li H. Forstermann U. Prevention of atherosclerosis by interference with the vascular nitric oxide system Curr. Pharm. Des. 2009 15 3133 3145 10.2174/138161209789058002 19754387
2. Li H. Forstermann U. Nitric oxide in the pathogenesis of vascular disease J. Pathol. 2000 190 244 254 10.1002/(SICI)1096-9896(200002)190:3 3.0.CO;2-8 10685059
3. Liu V.W. Huang P.L. Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice Cardiovasc. Res. 2008 77 19 29 17658499
4. Gunnett C.A. Lund D.D. McDowell A.K. Faraci F.M. Heistad D.D. Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunction Arterioscler. Thromb. Vasc. Biol. 2005 25 1617 1622 10.1161/01.ATV.0000172626.00296.ba 15933248
5. Chen S.J. Li S.Y. Shih C.C. Liao M.H. Wu C.C. NO contributes to abnormal vascular calcium regulation and reactivity induced by peritonitis-associated septic shock in rats Shock 2010 33 473 478 19749606
6. Shelkovnikov S. Gonick H.C. Peroxynitrite but not nitric oxide donors destroys epinephrine: HPLC measurement and rat aorta contractility Life Sci. 2004 75 2765 2773 10.1016/j.lfs.2004.04.044 15464828
7. Kessler P. Bauersachs J. Busse R. Schini-Kerth V.B. Inhibition of inducible nitric oxide synthase restores endothelium-dependent relaxations in proinflammatory mediator-induced blood vessels Arterioscler. Thromb. Vasc. Biol. 1997 17 1746 1755 10.1161/01.ATV.17.9.1746 9327773
8. Virdis A. Colucci R. Fornai M. Blandizzi C. Duranti E. Pinto S. Bernardini N. Segnani C. Antonioli L. Taddei S. Cyclooxygenase–2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: Role of inducible nitric-oxide synthase and oxidative stress J. Pharmacol. Exp. Ther. 2005 312 945 953 15547110
9. Eguchi D. D'Uscio L.V. Wambi C. Weiler D. Kovesdi I. O'Brien T. Katusic Z.S. Inhibitory effect of recombinant iNOS gene expression on vasomotor function of canine basilar artery Am. J. Physiol. Heart Circ. Physiol. 2002 283 H2560 H2566 12388312
10. Forstermann U. Sessa W.C. Nitric oxide synthases: Regulation and function Eur. Heart J. 2012 33 829 837 10.1093/eurheartj/ehr304 21890489
11. Julou-Schaeffer G. Gray G.A. Fleming I. Schott C. Parratt J.R. Stoclet J.C. Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway Am. J. Physiol. 1990 259 H1038 H1043 2221111
12. Pittner A. Nalos M. Asfar P. Yang Y. Ince C. Georgieff M. Bruckner U.B. Radermacher P. Froba G. Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia Intensiv. Care Med. 2003 29 312 316
13. Petros A. Lamb G. Leone A. Moncada S. Bennett D. Vallance P. Effects of a nitric oxide synthase inhibitor in humans with septic shock Cardiovasc. Res. 1994 28 34 39 10.1093/cvr/28.1.34 7509259
14. MacMicking J.D. Nathan C. Hom G. Chartrain N. Fletcher D.S. Trumbauer M. Stevens K. Xie Q.W. Sokol K. Hutchinson N. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase Cell 1995 81 641 650 10.1016/0092-8674(95)90085-3 7538909
15. Wang Z. Feng K. Yue M. Lu X. Zheng Q. Zhang H. Zhai Y. Li P. Yu L. Cai M. A non-synonymous SNP in the NOS2 associated with septic shock in patients with sepsis in Chinese populations Hum. Genet. 2013 132 337 346 10.1007/s00439-012-1253-4 23192595
16. Xia Y. Zweier J.L. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages Proc. Natl. Acad. Sci. USA 1997 94 6954 6958 10.1073/pnas.94.13.6954 9192673
17. Marfella R. di Filippo C. Esposito K. Nappo F. Piegari E. Cuzzocrea S. Berrino L. Rossi F. Giugliano D. D’Amico M. Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic mice Diabetes 2004 53 454 462 10.2337/diabetes.53.2.454 14747298
18. Pacher P. Beckman J.S. Liaudet L. Nitric oxide and peroxynitrite in health and disease Physiol. Rev. 2007 87 315 424 10.1152/physrev.00029.2006 17237348
19. Liaudet L. Rosenblatt-Velin N. Pacher P. Role of peroxynitrite in the cardiovascular dysfunction of septic shock Curr. Vasc. Pharmacol. 2013 11 196 207 23506498
20. Kuhlencordt P.J. Chen J. Han F. Astern J. Huang P.L. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E–knockout mice Circulation 2001 103 3099 3104 10.1161/01.CIR.103.25.3099 11425775
21. Iadecola C. Zhang F. Xu X. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage Am. J. Physiol. 1995 268 R286 R292 7530927
22. Iadecola C. Zhang F. Casey R. Nagayama M. Ross M.E. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene J. Neurosci. 1997 17 9157 9164 9364062
23. Li H. Xia N. Brausch I. Yao Y. Forstermann U. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells J. Pharmacol. Exp. Ther. 2004 310 926 932 10.1124/jpet.104.066639 15123766
24. Rodriguez-Pascual F. Hausding M. Ihrig-Biedert I. Furneaux H. Levy A.P. Forstermann U. Kleinert H. Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR J. Biol. Chem. 2000 275 26040 26049 10.1074/jbc.M910460199 10859327
25. Ishii K. Sheng H. Warner T.D. Forstermann U. Murad F. A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts Am. J. Physiol. 1991 261 H598 H603 1652215
26. Pautz A. Art J. Hahn S. Nowag S. Voss C. Kleinert H. Regulation of the expression of inducible nitric oxide synthase Nitric. Oxide. 2010 23 75 93 10.1016/j.niox.2010.04.007 20438856
27. Hausding M. Witteck A. Rodriguez-Pascual F. von Eichel-Streiber C. Forstermann U. Kleinert H. Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II Br. J. Pharmacol. 2000 131 553 561 10.1038/sj.bjp.0703607 11015307
28. Lattanzio V. Kroon P.A. Linsalata V. Cardinali A. Globe artichoke: A functional food and source of nutraceutical ingredients J. Funct. Foods 2009 1 131 144 10.1016/j.jff.2009.01.002
29. Saenz Rodriguez T. Garcia Gimenez D. de la Puerta Vazquez R. Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats Phytomedicine 2002 9 687 693 10.1078/094471102321621278 12587687
30. Kucukgergin C. Aydin A.F. Ozdemirler-Erata G. Mehmetcik G. Kocak-Toker N. Uysal M. Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet Biol. Trace. Elem. Res. 2010 135 264 274 10.1007/s12011-009-8484-9 19652921
31. Angelini A. di Pietro R. Centurione L. Castellani M.L. Conti P. Porreca E. Cuccurullo F. Inhibition of P-glycoprotein-mediated transport by S-adenosylmethionine and cynarin in multidrug-resistant human uterine sarcoma MES-SA/Dx5 cells J. Biol. Regul. Homeost. Agents 2012 26 495 504 23034269
32. Lopez-Molina D. Navarro-Martinez M.D. Rojas Melgarejo F. Hiner A.N. Chazarra S. Rodriguez-Lopez J.N. Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.) Phytochemistry 2005 66 1476 1484 10.1016/j.phytochem.2005.04.003 15960982
33. Costabile A. Kolida S. Klinder A. Gietl E. Bauerlein M. Frohberg C. Landschutze V. Gibson G.R. A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects Br. J. Nutr. 2010 104 1007 1017 10.1017/S0007114510001571 20591206
34. Zhu X. Zhang H. Lo R. Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities J. Agric. Food Chem. 2004 52 7272 7278 10.1021/jf0490192 15563206
35. Llorach R. Espin J.C. Tomas-Barberan F.A. Ferreres F. Artichoke (Cynara scolymus L.) byproducts as a potential source of health-promoting antioxidant phenolics J. Agric. Food Chem. 2002 50 3458 3464 10.1021/jf0200570 12033811
36. Wang M. Simon J.E. Aviles I.F. He K. Zheng Q.Y. Tadmor Y. Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.) J. Agric. Food Chem. 2003 51 601 608 10.1021/jf020792b 12537429
37. Zapolska-Downar D. Zapolski-Downar A. Naruszewicz M. Siennicka A. Krasnodebska B. Koldziej B. Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes Life Sci. 2002 71 2897 2808 10.1016/S0024-3205(02)02136-7 12377270
38. Juzyszyn Z. Czerny B. Pawlik A. Drozdzik M. The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells Phytother. Res. 2008 22 1159 1161 10.1002/ptr.2385 18780283
39. Perez-Garcia F. Adzet T. Canigueral S. Activity of artichoke leaf extract on reactive oxygen species in human leukocytes Free Radic. Res. 2000 33 661 665 10.1080/10715760000301171 11200096
40. Jimenez-Escrig A. Dragsted L.O. Daneshvar B. Pulido R. Saura-Calixto F. In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats J. Agric. Food Chem. 2003 51 5540 5545 10.1021/jf030047e 12926911
41. Magielse J. Verlaet A. Breynaert A. Keenoy B.M. Apers S. Pieters L. Hermans N. Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin-induced diabetic rat Mol. Nutr. Food Res. 2014 58 211 215 10.1002/mnfr.201300282 24254201
42. Brown J.E. Rice-Evans C.A. Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro Free Radic. Res. 1998 29 247 255 10.1080/10715769800300281 9802556
43. Wider B. Pittler M.H. Thompson-Coon J. Ernst E. Artichoke leaf extract for treating hypercholesterolaemia Cochrane. Database. Syst. Rev. 2013 3 CD003335
44. Bundy R. Walker A.F. Middleton R.W. Wallis C. Simpson H.C. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: A randomized, double blind placebo controlled trial Phytomedicine 2008 15 668 675 10.1016/j.phymed.2008.03.001 18424099
45. Rondanelli M. Giacosa A. Opizzi A. Faliva M.A. Sala P. Perna S. Riva A. Morazzoni P. Bombardelli E. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: A double-blind, randomized, placebo-controlled trial Int. J. Food Sci. Nutr. 2013 64 7 15 10.3109/09637486.2012.700920 22746542
46. Grande S. Bogani P. de Saizieu A. Schueler G. Galli C. Visioli F. Vasomodulating potential of mediterranean wild plant extracts J. Agric. Food Chem. 2004 52 5021 5026 10.1021/jf049436e 15291469
47. Roghani-Dehkordi F. Kamkhah A.F. Artichoke leaf juice contains antihypertensive effect in patients with mild hypertension J. Diet. Suppl. 2009 6 328 341 10.3109/19390210903280207 22435514
48. Wittemer S.M. Ploch M. Windeck T. Muller S.C. Drewelow B. Derendorf H. Veit M. Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans Phytomedicine 2005 12 28 38 10.1016/j.phymed.2003.11.002 15693705
49. Azzini E. Bugianesi R. Romano F. di Venere D. Miccadei S. Durazzo A. Foddai M.S. Catasta G. Linsalata V. Maiani G. Absorption and metabolism of bioactive molecules after oral consumption of cooked edible heads of Cynara scolymus L. (cultivar Violetto di Provenza) in human subjects: A pilot study Br. J. Nutr. 2007 97 963 969 17408528
50. Dong G.C. Chuang P.H. Chang K.C. Jan P.S. Hwang P.I. Wu H.B. Yi M. Zhou H.X. Chen H.M. Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor Pharm. Res. 2009 26 375 381 10.1007/s11095-008-9754-5 18989760
51. Wang L. Sweet D.H. Interaction of natural dietary and herbal anionic compounds and flavonoids with human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11) Evid. Based Complement. Alternat. Med. 2013 2013 612527 23573138
52. Galvano F. La Fauci L. Lazzarino G. Fogliano V. Ritieni A. Ciappellano S. Battistini N.C. Tavazzi B. Galvano G. Cyanidins: Metabolism and biological properties J. Nutr. Biochem. 2004 15 2 11 10.1016/j.jnutbio.2003.07.004 14711454
53. Serra D. Paixao J. Nunes C. Dinis T.C. Almeida L.M. Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human intestinal cells: Comparison with 5-aminosalicylic acid PLoS One 2013 8 e73001 24039842
54. Wang Q. Xia M. Liu C. Guo H. Ye Q. Hu Y. Zhang Y. Hou M. Zhu H. Ma J. Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages Life Sci. 2008 83 176 184 10.1016/j.lfs.2008.05.017 18619979
55. Sorrenti V. di Giacomo C. Acquaviva R. Bognanno M. Grilli E. D’Orazio N. Galvano F. Dimethylarginine dimethylaminohydrolase/nitric oxide synthase pathway in liver and kidney: Protective effect of cyanidin 3- O -beta- d -glucoside on ochratoxin-A toxicity Toxins (Basel) 2012 4 353 363 10.3390/toxins4050353 22778905
56. Min S.W. Ryu S.N. Kim D.H. Anti-inflammatory effects of black rice, cyanidin-3- O -beta- d -glycoside, and its metabolites, cyanidin and protocatechuic acid Int. Immunopharmacol. 2010 10 959 966 10.1016/j.intimp.2010.05.009 20669401
57. Kim J.M. Kim J.S. Yoo H. Choung M.G. Sung M.K. Effects of black soybean [Glycine max (L.) Merr.] seed coats and its anthocyanidins on colonic inflammation and cell proliferation in vitro and in vivo J. Agric. Food Chem. 2008 56 8427 8433 10.1021/jf801342p 18710248
58. Schmidt N. Pautz A. Art J. Rauschkolb P. Jung M. Erkel G. Goldring M.B. Kleinert H. Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes Biochem. Pharmacol. 2010 79 722 732 10.1016/j.bcp.2009.10.012 19854161
59. Xia N. Strand S. Schlufter F. Siuda D. Reifenberg G. Kleinert H. Forstermann U. Li H. Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol Nitric Oxide 2013 32 29 35 10.1016/j.niox.2013.04.001 23583951
60. Li H. Forstermann U. Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene Mol. Pharmacol. 2000 57 427 435 10692481
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.