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Nanostructured lipid carriers for percutaneous administration of alkaloids isolated from Aconitum sinomontanum 원문보기

Journal of nanobiotechnology, v.13, 2015년, pp.47 -   

Guo, Teng (Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203 People’s Republic of China) ,  Zhang, Yongtai (Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203 People’s Republic of China) ,  Zhao, Jihui (Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203 People’s Republic of China) ,  Zhu, Chunyun (Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203 People’s Republic of China) ,  Feng, Nianping (Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203 People’s Republic of China)

Abstract AI-Helper 아이콘AI-Helper

BackgroundLipid-based nanosystems have great potential for transdermal drug delivery. In this study, nanostructured lipid carriers (NLCs) for short-acting alkaloids lappacontine (LA) and ranaconitine (RAN) isolated from Aconitum sinomontanum (AAS) at 69.47 and 9.16% (w/w) yields, respectively, were ...

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참고문헌 (39)

  1. 1. Bisset NG Arrow poisons in China. Part II. Aconitum-botany, chemistry, and pharmacology J Ethnopharmacol 1981 4 247 336 10.1016/0378-8741(81)90001-5 7029146 

  2. 2. Yang F Ito Y Preparative separation of lappaconitine, ranaconitine, N -deacetyllappaconitine and N -deacetylranaconitine from crude alkaloids of sample Aconitum sinomontanum Nakai by high-speed counter-current chromatography J Chromatogr A 2002 943 219 225 10.1016/S0021-9673(01)01464-9 11833641 

  3. 3. Shi ZM, Jiang SH, Tian JH (2003) Suppository containing alkaloids from Datura and Aconitum and fatty glycerides for the treatment of ache caused by cancer. Chinese patent. CN 03150768.9 

  4. 4. Xie FM Wang HC Shu HL Li JH Jiang JR Chang JP Separation and characterization of the metabolic products of lappaconitine in rat urine by high-performance liquid chromatography J Chromatogr 1990 526 109 118 10.1016/S0378-4347(00)82488-3 2341523 

  5. 5. Guan YZ Shi YB Wang H Summary on the advanced research of lappaconite hydrobromide Theory Pr Chin Med 2005 15 1838 1840 

  6. 6. Liang ZF Lyu YP Yuan W Liu YL Zhu XC Dose-effect relationship of lappaconitine Chin Pharmacol Bull 1993 9 146 

  7. 7. Wang Q, Chen WW, Liu HL (2008) Transdermal patch of Aconitum sinomontanum , its formulation and application as anti-inflammatory and antalgic agents. Chinese patent. CN 200810224028.8 

  8. 8. Cevc G Vierl U Nanotechnology and the transdermal route: a state of the art review and critical appraisal J Control Release 2010 141 277 299 10.1016/j.jconrel.2009.10.016 19850095 

  9. 9. Elnaggar YS El-Massik MA Abdallah OY Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles Int J Nanomedicine 2011 6 3195 3205 10.2147/IJN.S25825 22238508 

  10. 10. Manjunath K Venkateswarlu V Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration J Control Release 2005 107 215 228 10.1016/j.jconrel.2005.06.006 16014318 

  11. 11. Tiwari R Pathak K Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake Int J Pharm 2011 415 232 243 10.1016/j.ijpharm.2011.05.044 21640809 

  12. 12. Mller RH Radtke M Wissing SA Nanostructured lipid matrices for improved microencapsulation of drugs Int J Pharm 2002 242 121 128 10.1016/S0378-5173(02)00180-1 12176234 

  13. 13. Negi LM Jaggi M Talegaonkar S Development of protocol for screening the formulation components and the assessment of common quality problems of nano-structured lipid carriers Int J Pharm 2014 461 403 410 10.1016/j.ijpharm.2013.12.006 24345574 

  14. 14. Schäfer-Korting M Mehnert W Korting HC Lipid nanoparticles for improved topical application of drugs for skin diseases Adv Drug Deliv Rev 2007 59 427 443 10.1016/j.addr.2007.04.006 17544165 

  15. 15. Siekmann B Westesen K Melt-homogenized solid lipid nanoparticles stabilized by the nonionic surfactant tyloxapol. I. Preparation and particle size determination Pharm Pharmacol Lett 1994 3 194 197 

  16. 16. Rahman HS Rasedee A How CW Abdul AB Zeenathul NA Othman HH Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect Int J Nanomedicine. 2013 8 2769 2781 10.2147/IJN.S45313 23946649 

  17. 17. Bunjes H Unruh T Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering Adv Drug Deliv Rev 2007 59 379 402 10.1016/j.addr.2007.04.013 17658653 

  18. 18. Kuntsche J Westesen K Drechsler M Koch HJ Bunjes H Supercooled smectic nanoparticles: a potential novel carrier system for poorly water soluble drugs Pharm Res 2004 21 1834 1843 10.1023/B:PHAM.0000045237.46019.6e 15553230 

  19. 19. Fang JY Fang CL Liu CH Su YH Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC) Eur J Pharm Biopharm 2008 70 633 640 10.1016/j.ejpb.2008.05.008 18577447 

  20. 20. Bondì ML Craparo EF Giammona G Cervello M Azzolina A Diana P Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies Drug Deliv 2007 14 61 67 10.1080/10717540600739914 17364869 

  21. 21. Wang LH Rothberg KG Anderson RG Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pits formation J Cell Biol 1993 123 1107 1117 10.1083/jcb.123.5.1107 8245121 

  22. 22. Verheijen I Tourlousse D Vanderheyden PM Backer JP Vauquelin G Effect of saponin and filipin on antagonist binding to AT1 receptors in intact cells Biochem Pharmacol 2004 67 1601 1606 10.1016/j.bcp.2004.01.004 15041477 

  23. 23. Sit KH Bay BH Wong KP Effect of genistein, a tyrosine-specific protein-kinase inhibitor, on cell rouding by pH upshifting In Vitro Cell Dev Biol Anim 1993 29A 395 402 10.1007/BF02633988 8314734 

  24. 24. Boucrot E Saffarian S Massol R Kirchhausen T Ehrlich M Role of lipids and actin in the formation of clathrin-coated pits Exp Cell Res 2006 31 4036 4048 10.1016/j.yexcr.2006.09.025 17097636 

  25. 25. Iverson TG Skotland T Sandvig K Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies Nano Today 2011 6 176 185 10.1016/j.nantod.2011.02.003 

  26. 26. Zhang W Liu J Zhang Q Li X Yu S Yang X Enhanced cellular uptake and anti-proliferating effect of chitosan hydrochlorides modified genistein loaded NLC on human lens epithelial cells Int J Pharm 2014 471 118 126 10.1016/j.ijpharm.2014.05.030 24858387 

  27. 27. Hosoi R Matsuyama Y Hirose S Koyama Y Matsuda T Gee A Characterization of (14) C-acetate uptake in cultured rat astrocytes Brain Res 2009 1253 69 73 10.1016/j.brainres.2008.11.068 19073161 

  28. 28. Seong K Seo H Ahn W Yoo D Cho S Khang G Enhanced cytosolic drug delivery using fully biodegradable poly(amino oxalate) particles J Control Release 2011 152 257 263 10.1016/j.jconrel.2011.02.025 21371509 

  29. 29. Schwarz JC Baisaeng N Hoppel M Löw M Keck CM Valenta C Ultra-small NLC for improved dermal delivery of coenyzme Q10 Int J Pharm 2013 447 213 217 10.1016/j.ijpharm.2013.02.037 23438979 

  30. 30. Mak WC Richter H Patzelt A Sterry W Lai KK Renneberg R Drug delivery into the skin by degradable particles Eur J Pharm Biopharm 2011 79 23 27 10.1016/j.ejpb.2011.03.021 21457780 

  31. 31. Lee SG Jeong JH Lee KM Jeong KH Yang H Kim M Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule Int J Nanomedicine 2014 9 288 289 

  32. 32. Liu Y Wang P Sun C Feng N Zhou W Yang Y Wheat germ agglutinin-grafted lipid nanoparticles: preparation and in vitro evaluation of the association with Caco-2 monolayers Int J Pharm 2010 397 155 163 10.1016/j.ijpharm.2010.06.030 20599600 

  33. 33. Zhuang CY Li N Wang M Zhang XN Pan WS Peng JJ Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability Int J Pharm 2010 394 179 185 10.1016/j.ijpharm.2010.05.005 20471464 

  34. 34. Elnaggar YS El-Massik MA Abdallah OY Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization Int J Pharm 2009 380 133 141 10.1016/j.ijpharm.2009.07.015 19635537 

  35. 35. Lopes R Eleutério CV Gonçalves LMD Cruz MEM Almeida AJ Lipid nanoparticles containing oryzalin for the treatment of leishmaniasis Eur J Pharm Sci 2012 45 442 450 10.1016/j.ejps.2011.09.017 21983568 

  36. 36. Chiu YL Ho YC Chen YM Peng SF Ke CJ Chen KJ The characteristics, cellular uptake and intracellular trafficking of nanoparticles made of hydrophobically-modifiedchitosan J Control Release 2010 146 152 159 10.1016/j.jconrel.2010.05.023 20580915 

  37. 37. Shen LN Zhang YT Wang Q Xu L Feng NP Preparation and evaluation of microemulsion-based transdermal delivery of total flavone of rhizoma arisaematis Int J Nanomedicine 2014 9 3453 3464 25092976 

  38. 38. Manconi M Sinico C Caddeo C Vila AO Valenti D Fadda AM Penetration enhancer containing vesicles as carriers for dermal delivery of tretinoin Int J Pharm 2011 412 37 46 10.1016/j.ijpharm.2011.03.068 21530626 

  39. 39. Han JZ Sun J Zhu QG Liu JY Hu JH Chen F A modified LC-MS/MS method for determination of tetramethylpyrazine in microdialysis samples and calibration of home-made linear probes Biomed Chromatogr 2012 26 1276 1281 10.1002/bmc.2689 22334234 

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