다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Diabetes & metabolism journal, v.42 no.2, 2018년, pp.117 - 127
Song, Do Kyeong (Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) , Choi, Jong Han (Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) , Kim, Min-Seon (Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.)
AI-Helper
Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as importan...
1 Bhurosy T Jeewon R Overweight and obesity epidemic in developing countries: a problem with diet, physical activity, or socioeconomic status? ScientificWorldJournal 2014 2014 964236 25379554
2 Hruby A Hu FB The epidemiology of obesity: a big picture Pharmacoeconomics 2015 33 673 689 25471927
3 Maes HH Neale MC Eaves LJ Genetic and environmental factors in relative body weight and human adiposity Behav Genet 1997 27 325 351 9519560
4 Oh EC Vasanth S Katsanis N Metabolic regulation and energy homeostasis through the primary Cilium Cell Metab 2015 21 21 31 25543293
5 Kebede MA Attie AD Insights into obesity and diabetes at the intersection of mouse and human genetics Trends Endocrinol Metab 2014 25 493 501 25034129
6 Ingalls AM Dickie MM Snell GD Obese, a new mutation in the house mouse J Hered 1950 41 317 318 14824537
7 Tartaglia LA Dembski M Weng X Deng N Culpepper J Devos R Richards GJ Campfield LA Clark FT Deeds J Muir C Sanker S Moriarty A Moore KJ Smutko JS Mays GG Wool EA Monroe CA Tepper RI Identification and expression cloning of a leptin receptor, OB-R Cell 1995 83 1263 1271 8548812
8 Bloodgood RA From central to rudimentary to primary: the history of an underappreciated organelle whose time has come. The primary cilium Methods Cell Biol 2009 94 3 52 20362083
9 Berbari NF O'Connor AK Haycraft CJ Yoder BK The primary cilium as a complex signaling center Curr Biol 2009 19 R526 R535 19602418
10 Hildebrandt F Benzing T Katsanis N Ciliopathies N Engl J Med 2011 364 1533 1543 21506742
11 Louvi A Grove EA Cilia in the CNS: the quiet organelle claims center stage Neuron 2011 69 1046 1060 21435552
12 Christensen ST Pedersen LB Schneider L Satir P Sensory cilia and integration of signal transduction in human health and disease Traffic 2007 8 97 109 17241444
13 Hsiao YC Tuz K Ferland RJ Trafficking in and to the primary cilium Cilia 2012 1 4 23351793
14 Cole DG Diener DR Himelblau AL Beech PL Fuster JC Rosenbaum JL Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons J Cell Biol 1998 141 993 1008 9585417
15 Pazour GJ Wilkerson CG Witman GB A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT) J Cell Biol 1998 141 979 992 9585416
16 Pazour GJ Dickert BL Vucica Y Seeley ES Rosenbaum JL Witman GB Cole DG Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella J Cell Biol 2000 151 709 718 11062270
17 Cortellino S Wang C Wang B Bassi MR Caretti E Champeval D Calmont A Jarnik M Burch J Zaret KS Larue L Bellacosa A Defective ciliogenesis, embryonic lethality and severe impairment of the sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4 Dev Biol 2009 325 225 237 19000668
18 Takeda S Yonekawa Y Tanaka Y Okada Y Nonaka S Hirokawa N Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis J Cell Biol 1999 145 825 836 10330409
19 Jiang J Hui CC Hedgehog signaling in development and cancer Dev Cell 2008 15 801 812 19081070
20 Varjosalo M Taipale J Hedgehog: functions and mechanisms Genes Dev 2008 22 2454 2472 18794343
21 Echelard Y Epstein DJ St-Jacques B Shen L Mohler J McMahon JA McMahon AP Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity Cell 1993 75 1417 1430 7916661
22 Krauss S Concordet JP Ingham PW A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos Cell 1993 75 1431 1444 8269519
23 Roelink H Augsburger A Heemskerk J Korzh V Norlin S Ruiz i Tanabe Y Placzek M Edlund T Jessell TM Dodd J Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord Cell 1994 76 761 775 8124714
24 Kim J Kato M Beachy PA Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus Proc Natl Acad Sci U S A 2009 106 21666 21671 19996169
25 Brennan D Chen X Cheng L Mahoney M Riobo NA Noncanonical Hedgehog signaling Vitam Horm 2012 88 55 72 22391299
26 Teperino R Aberger F Esterbauer H Riobo N Pospisilik JA Canonical and non-canonical Hedgehog signalling and the control of metabolism Semin Cell Dev Biol 2014 33 81 92 24862854
27 Benzler J Andrews ZB Pracht C Stohr S Shepherd PR Grattan DR Tups A Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice Endocrinology 2013 154 4737 4745 24105484
28 Nusse R Varmus H Three decades of Wnts: a personal perspective on how a scientific field developed EMBO J 2012 31 2670 2684 22617420
29 Rao TP Kuhl M An updated overview on Wnt signaling pathways: a prelude for more Circ Res 2010 106 1798 1806 20576942
30 Molenaar M van de Wetering M Oosterwegel M Peterson-Maduro J Godsave S Korinek V Roose J Destree O Clevers H XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos Cell 1996 86 391 399 8756721
31 Helfer G Tups A Hypothalamic Wnt signalling and its role in energy balance regulation J Neuroendocrinol 2016 28 12368 26802435
32 Aznar N Billaud M Primary cilia bend LKB1 and mTOR to their will Dev Cell 2010 19 792 794 21145495
33 Ravindran S Kuruvilla V Wilbur K Munusamy S Nephroprotective effects of metformin in diabetic nephropathy J Cell Physiol 2017 232 731 742 27627216
34 Pampliega O Cuervo AM Autophagy and primary cilia: dual interplay Curr Opin Cell Biol 2016 39 1 7 26826446
35 Tang Z Lin MG Stowe TR Chen S Zhu M Stearns T Franco B Zhong Q Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites Nature 2013 502 254 257 24089205
36 Pampliega O Orhon I Patel B Sridhar S Diaz-Carretero A Beau I Codogno P Satir BH Satir P Cuervo AM Functional interaction between autophagy and ciliogenesis Nature 2013 502 194 200 24089209
37 Jin H White SR Shida T Schulz S Aguiar M Gygi SP Bazan JF Nachury MV The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia Cell 2010 141 1208 1219 20603001
38 Badano JL Mitsuma N Beales PL Katsanis N The ciliopathies: an emerging class of human genetic disorders Annu Rev Genomics Hum Genet 2006 7 125 148 16722803
39 Jacobsson JA Schioth HB Fredriksson R The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO Obes Rev 2012 13 1096 1109 22931202
40 Stratigopoulos G Martin Carli JF O'Day DR Wang L Leduc CA Lanzano P Chung WK Rosenbaum M Egli D Doherty DA Leibel RL Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice Cell Metab 2014 19 767 779 24807221
41 Millan MJ Millan MH Reid LD Herz A The role of the mediobasal arcuate hypothalamus in relation to opioid systems in the control of ingestive behaviour in the rat Brain Res 1986 381 29 42 2875765
42 Morton GJ Cummings DE Baskin DG Barsh GS Schwartz MW Central nervous system control of food intake and body weight Nature 2006 443 289 295 16988703
43 Kang GM Han YM Ko HW Kim J Oh BC Kwon I Kim MS Leptin elongates hypothalamic neuronal cilia via transcriptional regulation and actin destabilization J Biol Chem 2015 290 18146 18155 26041775
44 Davenport JR Watts AJ Roper VC Croyle MJ van Groen T Wyss JM Nagy TR Kesterson RA Yoder BK Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease Curr Biol 2007 17 1586 1594 17825558
45 Han YM Kang GM Byun K Ko HW Kim J Shin MS Kim HK Gil SY Yu JH Lee B Kim MS Leptin-promoted cilia assembly is critical for normal energy balance J Clin Invest 2014 124 2193 2197 24667636
46 Schwartz MW Woods SC Porte D Jr Seeley RJ Baskin DG Central nervous system control of food intake Nature 2000 404 661 671 10766253
47 Rahmouni K Fath MA Seo S Thedens DR Berry CJ Weiss R Nishimura DY Sheffield VC Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome J Clin Invest 2008 118 1458 1467 18317593
48 Berbari NF Pasek RC Malarkey EB Yazdi SM McNair AD Lewis WR Nagy TR Kesterson RA Yoder BK Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice Proc Natl Acad Sci U S A 2013 110 7796 7801 23599282
49 Seo S Guo DF Bugge K Morgan DA Rahmouni K Sheffield VC Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling Hum Mol Genet 2009 18 1323 1331 19150989
50 Berbari NF Lewis JS Bishop GA Askwith CC Mykytyn K Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia Proc Natl Acad Sci U S A 2008 105 4242 4246 18334641
51 Seeley RJ Woods SC Monitoring of stored and available fuel by the CNS: implications for obesity Nat Rev Neurosci 2003 4 901 909 14595401
52 Pittenger MF Mackay AM Beck SC Jaiswal RK Douglas R Mosca JD Moorman MA Simonetti DW Craig S Marshak DR Multilineage potential of adult human mesenchymal stem cells Science 1999 284 143 147 10102814
53 Marion V Stoetzel C Schlicht D Messaddeq N Koch M Flori E Danse JM Mandel JL Dollfus H Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation Proc Natl Acad Sci U S A 2009 106 1820 1825 19190184
54 Ross SE Hemati N Longo KA Bennett CN Lucas PC Erickson RL MacDougald OA Inhibition of adipogenesis by Wnt signaling Science 2000 289 950 953 10937998
55 Wright WS Longo KA Dolinsky VW Gerin I Kang S Bennett CN Chiang SH Prestwich TC Gress C Burant CF Susulic VS MacDougald OA Wnt10b inhibits obesity in ob/ob and agouti mice Diabetes 2007 56 295 303 17259372
56 Suh JM Gao X McKay J McKay R Salo Z Graff JM Hedgehog signaling plays a conserved role in inhibiting fat formation Cell Metab 2006 3 25 34 16399502
57 Pospisilik JA Schramek D Schnidar H Cronin SJ Nehme NT Zhang X Knauf C Cani PD Aumayr K Todoric J Bayer M Haschemi A Puviindran V Tar K Orthofer M Neely GG Dietzl G Manoukian A Funovics M Prager G Wagner O Ferrandon D Aberger F Hui CC Esterbauer H Penninger JM Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate Cell 2010 140 148 160 20074523
58 Teperino R Amann S Bayer M McGee SL Loipetzberger A Connor T Jaeger C Kammerer B Winter L Wiche G Dalgaard K Selvaraj M Gaster M Lee-Young RS Febbraio MA Knauf C Cani PD Aberger F Penninger JM Pospisilik JA Esterbauer H Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat Cell 2012 151 414 426 23063129
59 Ogden SK Fei DL Schilling NS Ahmed YF Hwa J Robbins DJ G protein Galphai functions immediately downstream of smoothened in Hedgehog signalling Nature 2008 456 967 970 18987629
60 Polizio AH Chinchilla P Chen X Manning DR Riobo NA Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins Sci Signal 2011 4 pt7 22114142
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.