[논문]Reinterpretation of the results of a pooled analysis of dietary carotenoid intake and breast cancer risk by using the interval collapsing method

Bae, Jong-Myon

doi:10.4178/epih.e2016024

Reinterpretation of the results of a pooled analysis of dietary carotenoid intake and breast cancer risk by using the interval collapsing method 원문보기

Epidemiology and health, v.38, 2016년, pp.e2016024 -

Bae, Jong-Myon

Abstract ▼ AI-Helper

OBJECTIVES:A pooled analysis of 18 prospective cohort studies reported in 2012 for evaluating carotenoid intakes and breast cancer risk defined by estrogen receptor (ER) and progesterone receptor (PR) statuses by using the “highest versus lowest intake” method (HLM). By applying the interval collapsing method (ICM) to maximize the use of the estimated information, we reevaluated the results of the previous analysis in order to reinterpret the inferences made.METHODS:In order to estimate the summary effect size (sES) and its 95% confidence interval (CI), meta-analyses with the random-effects model were conducted for adjusted relative risks and their 95% CI from the second to the fifth interval according to five kinds of carotenoids and ER/PR status.RESULTS:The following new findings were identified: α-Carotene and β-cryptoxanthin have protective effects on overall breast cancer. All five kinds of carotenoids showed protective effects on ER− breast cancer. β-Carotene level increased the risk of ER+ or ER+/PR+ breast cancer. α-Carotene, β-carotene, lutein/zeaxanthin, and lycopene showed a protective effect on ER−/PR+ or ER−/PR− breast cancer.CONCLUSIONS:The new facts support the hypothesis that carotenoids that show anticancer effects with anti-oxygen function might reduce the risk of ER− breast cancer. Based on the new facts, the modification of the effects of α-carotene, β-carotene, and β-cryptoxanthin should be evaluated according to PR and ER statuses.

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참고문헌 (7)

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3 Cotterchio M Kreiger N Theis B Sloan M Bahl S Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroup Cancer Epidemiol Biomarkers Prev 2003 12 1053 1060 14578142
4 Rao AV Rao LG Carotenoids and human health Pharmacol Res 2007 55 207 216 17349800

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5 Zhang X Spiegelman D Baglietto L Bernstein L Boggs DA van den Brandt PA Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies Am J Clin Nutr 2012 95 713 725 22277553

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6 Bae JM Comparison of methods of extracting information for metaanalysis of observational studies in nutritional epidemiology Epidemiol Health 2016 38 e2016024 27283141
7 Chug-Ahuja JK Holden JM Forman MR Mangels AR Beecher GR Lanza E The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods J Am Diet Assoc 1993 93 318 323 8440830

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Reinterpretation of the results of a pooled analysis of dietary carotenoid intake and breast cancer risk by using the interval collapsing method 원문보기

Abstract ▼ AI-Helper

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참고문헌 (7)

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