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NTIS 바로가기Journal of natural products, v.81 no.8, 2018년, pp.1905 - 1909
Monsen, Paige J. (Department of Chemistry , University of Louisville , 2320 South Brook Street , Louisville , Kentucky 40292 , United States) , Luzzio, Frederick A.
Annonacin (1) was isolated from the North American pawpaw (Asimina triloba), as reported earlier from these laboratories. Natural 1 was submitted to the rat aortic ring bioassay for evaluation of antiangiogenic activity and was found to inhibit microvessel growth (IC50 value of 3 μM). 4,10,15,20-...
Gu, Z.-M., Zhou, D., Wu, J., Shi, G., Zeng, L., McLaughlin, J. L.. Screening for Annonaceous Acetogenins in Bioactive Plant Extracts by Liquid Chromatography/Mass Spectrometry. Journal of natural products, vol.60, no.3, 242-248.
Carmen Zafra-Polo, M., Figadère, Bruno, Gallardo, Teresa, Tormo, JoséR., Cortes, Diego. Natural acetogenins from annonaceae, synthesis and mechanisms of action. Phytochemistry, vol.48, no.7, 1087-1117.
Bermejo, Almudena, Figadère, Bruno, Zafra-Polo, Maria-Carmen, Barrachina, Isabel, Estornell, Ernesto, Cortes, Diego. Acetogenins from Annonaceae: recent progress in isolation, synthesis and mechanisms of action. Natural product reports : a journal of current developments in bio-organic chemistry, vol.22, no.2, 269-303.
Miyoshi, Hideto, Ohshima, Michiyo, Shimada, Hiroko, Akagi, Toshio, Iwamura, Hajime, McLaughlin, Jerry L.. Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I. Biochimica et biophysica acta, Bioenergetics, vol.1365, no.3, 443-452.
Lannuzel, A, Michel, P.P, Höglinger, G.U, Champy, P, Jousset, A, Medja, F, Lombès, A, Darios, F, Gleye, C, Laurens, A, Hocquemiller, R, Hirsch, E.C, Ruberg, M. The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism. Neuroscience, vol.121, no.2, 287-296.
Helley, Martin P., Pinnell, Jennifer, Sportelli, Carolina, Tieu, Kim. Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson’s Disease. Frontiers in genetics, vol.8, 177-.
McLaughlin, Jerry L.. Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products. Journal of natural products, vol.71, no.7, 1311-1321.
Pomper, Kirk W., Lowe, Jeremiah D., Crabtree, Sheri B., Keller, William. Identification of Annonaceous Acetogenins in the Ripe Fruit of the North American Pawpaw (Asimina triloba). Journal of agricultural and food chemistry, vol.57, no.18, 8339-8343.
Champy, Pierre, Höglinger, Günter U., Féger, Jean, Gleye, Christophe, Hocquemiller, Reynald, Laurens, Alain, Guérineau, Vincent, Laprévote, Olivier, Medja, Fadia, Lombès, Anne, Michel, Patrick P., Lannuzel, Annie, Hirsch, Etienne C., Ruberg, Merle. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. Journal of neurochemistry, vol.88, no.1, 63-69.
Escobar-Khondiker, Myriam, Höllerhage, Matthias, Muriel, Marie-Paule, Champy, Pierre, Bach, Antoine, Depienne, Christel, Respondek, Gesine, Yamada, Elizabeth S., Lannuzel, Annie, Yagi, Takao, Hirsch, Etienne C., Oertel, Wolfgang H., Jacob, Ralf, Michel, Patrick P., Ruberg, Merle, Höglinger, Günter U.. Annonacin, a Natural Mitochondrial Complex I Inhibitor, Causes Tau Pathology in Cultured Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.27, no.29, 7827-7837.
Hollerhage, M., Matusch, A., Champy, P., Lombes, A., Ruberg, M., Oertel, W.H., Hoglinger, G.U.. Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. Experimental neurology, vol.220, no.1, 133-142.
Yamada, E.S., Respondek, G., Mussner, S., de Andrade, A., Hollerhage, M., Depienne, C., Rastetter, A., Tarze, A., Friguet, B., Salama, M., Champy, P., Oertel, W.H., Hoglinger, G.U.. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Experimental neurology, vol.253, 113-125.
Bonneau, N., Schmitz-Afonso, I., Brunelle, A., Touboul, D., Champy, P.. Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC-MS/MS and application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol.1004, 46-52.
Potts, L.F., Luzzio, F.A., Smith, S.C., Hetman, M., Champy, P., Litvan, I.. Annonacin in Asimina triloba fruit: Implication for neurotoxicity. Neurotoxicology, vol.33, no.1, 53-58.
Coothankandaswamy, Veena, Liu, Yang, Mao, Shui-Chun, Morgan, J. Brian, Mahdi, Fakhri, Jekabsons, Mika B., Nagle, Dale G., Zhou, Yu-Dong. The Alternative Medicine Pawpaw and Its Acetogenin Constituents Suppress Tumor Angiogenesis via the HIF-1/VEGF Pathway. Journal of natural products, vol.73, no.5, 956-961.
Lab. Invest. Nicosia R. F. 115 63 1990
Karimov, Rashad R., Sharma, Ankit, Hartwig, John F.. Late Stage Azidation of Complex Molecules. ACS central science, vol.2, no.10, 715-724.
Gehringer, Matthias, Laufer, Stefan A.. Click Chemistry: Novel Applications in Cell Biology and Drug Discovery. Angewandte Chemie. international edition, vol.56, no.49, 15504-15505.
Tulloch, Lindsay B., Menzies, Stefanie K., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Zacharova, Marija K., Florence, Gordon J., Smith, Terry K.. Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues. PLoS neglected tropical diseases, vol.11, no.9, e0005886-.
Bonneau, N., Schmitz-Afonso, I., Brunelle, A., Touboul, D., Champy, P.. Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS. Toxicon, vol.118, 129-133.
Monaghan-Benson, E., Wittchen, E.S.. In Vitro Analyses of Endothelial Cell Permeability. Methods in molecular biology, vol.763, 281-290.
Ottaviani, G., Martel, S., Carrupt, P.-A.. Parallel Artificial Membrane Permeability Assay: A New Membrane for the Fast Prediction of Passive Human Skin Permeability. Journal of medicinal chemistry, vol.49, no.13, 3948-3954.
Malakoutikhah, Morteza, Teixidó, Meritxell, Giralt, Ernest. Toward an Optimal Blood−Brain Barrier Shuttle by Synthesis and Evaluation of Peptide Libraries. Journal of medicinal chemistry, vol.51, no.16, 4881-4889.
Maalej, E., Chabchoub, F., Oset-Gasque, M.J., Esquivias-Perez, M., Gonzalez, M.P., Monjas, L., Perez, C., de los Rios, C., Rodriguez-Franco, M.I., Iriepa, I., Moraleda, I., Chioua, M., Romero, A., Marco-Contelles, J., Samadi, A.. Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease. European journal of medicinal chemistry, vol.54, 750-763.
Campbell, Scott D., Regina, Karen J., Kharasch, Evan D.. Significance of Lipid Composition in a Blood-Brain Barrier–Mimetic PAMPA Assay. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening, vol.19, no.3, 437-444.
Furukawa, Akihiro, Townsend, Chad E., Schwochert, Joshua, Pye, Cameron R., Bednarek, Maria A., Lokey, R. Scott. Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry. Journal of medicinal chemistry, vol.59, no.20, 9503-9512.
Elkamhawy, Ahmed, Park, Jung-eun, Hassan, Ahmed H.E., Ra, Hyunhwa, Pae, Ae Nim, Lee, Jiyoun, Park, Beoung-Geon, Moon, Bongjin, Park, Hyun-Mee, Roh, Eun Joo. Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction. European journal of medicinal chemistry, vol.128, 56-69.
Freese, C., Hanada, S., Fallier-Becker, P., Kirkpatrick, C.J., Unger, R.E.. Identification of neuronal and angiogenic growth factors in an in vitro blood-brain barrier model system: Relevance in barrier integrity and tight junction formation and complexity. Microvascular research, vol.111, 1-11.
Garegg, Per J., Samuelsson, Bertil. Novel reagent system for converting a hydroxy-group into an iodo-group in carbohydrates with inversion of configuration. Journal of the Chemical Society, Chemical communications, vol.1979, no.22, 978-980.
Garegg, Per J., Johansson, Rolf, Ortega, Carmen, Samuelsson, Bertil. Novel reagent system for converting a hydroxy-group into an iodogroup in carbohydrates with inversion of configuration. Part 3. Journal of the Chemical Society. Perkin transactions I, vol.1982, 681-683.
Kruger, Erwin A, Figg, William D. TNP-470: an angiogenesis inhibitor in clinical development for cancer. Expert opinion on investigational drugs, vol.9, no.6, 1383-1396.
Wilhelm, Scott M., Adnane, Lila, Newell, Philippa, Villanueva, Augusto, Llovet, Josep M., Lynch, Mark. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Molecular cancer therapeutics, vol.7, no.10, 3129-3140.
Chojnacki, Jeremy E., Liu, Kai, Yan, Xing, Toldo, Stefano, Selden, Tyler, Estrada, Martin, Rodríguez-Franco, María Isabel, Halquist, Matthew S., Ye, Dexian, Zhang, Shijun. Discovery of 5-(4-Hydroxyphenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide as a Neuroprotectant for Alzheimer’s Disease by Hybridization of Curcumin and Melatonin. ACS chemical neuroscience, vol.5, no.8, 690-699.
Green, Douglas R., Reed, John C.. Mitochondria and Apoptosis. Science, vol.281, no.5381, 1309-1312.
Mattson, Mark P.. Apoptosis in neurodegenerative disorders. Nature reviews. Molecular cell biology, vol.1, no.2, 120-130.
Mattson, Mark P., Kroemer, Guido. Mitochondria in cell death: novel targets for neuroprotection and cardioprotection. Trends in molecular medicine, vol.9, no.5, 196-205.
Kroemer, Guido, Galluzzi, Lorenzo, Brenner, Catherine. Mitochondrial Membrane Permeabilization in Cell Death. Physiological reviews, vol.87, no.1, 99-163.
Kann, Oliver, Kovács, Richard. Mitochondria and neuronal activity. American journal of physiology. Cell physiology, vol.292, no.2, C641-C657.
Li, Nianyu, Ragheb, Kathy, Lawler, Gretchen, Sturgis, Jennie, Rajwa, Bartek, Melendez, J. Andres, Robinson, J. Paul. Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production. The Journal of biological chemistry, vol.278, no.10, 8516-8525.
Castello, Pablo R., Drechsel, Derek A., Patel, Manisha. Mitochondria Are a Major Source of Paraquat-induced Reactive Oxygen Species Production in the Brain. The Journal of biological chemistry, vol.282, no.19, 14186-14193.
Kerns, Edward H., Di, Li, Petusky, Susan, Farris, Michele, Ley, Rob, Jupp, Phil. Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery. Journal of pharmaceutical sciences : a publication of the American Pharmaceutical Association, vol.93, no.6, 1440-1453.
Di, Li, Kerns, Edward H, Fan, Kristi, McConnell, Oliver J, Carter, Guy T. High throughput artificial membrane permeability assay for blood–brain barrier. European journal of medicinal chemistry, vol.38, no.3, 223-232.
Vucicevic, J., Nikolic, K., Dobricic, V., Agbaba, D.. Prediction of blood-brain barrier permeation of α-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis. European journal of pharmaceutical sciences, vol.68, 94-105.
Houdai, Toshihiro, Matsuoka, Shigeru, Matsumori, Nobuaki, Murata, Michio. Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate. Biochimica et biophysica acta, Biomembranes, vol.1667, no.1, 91-100.
Ehrhardt, Carsten, Kneuer, Carsten, Bies, Christiane, Lehr, Claus-Michael, Kim, Kwang-Jin, Bakowsky, Udo. Salbutamol is actively absorbed across human bronchial epithelial cell layers. Pulmonary pharmacology & therapeutics, vol.18, no.3, 165-170.
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