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Antiangiogenic Activity and Chemical Derivatization of the Neurotoxic Acetogenin Annonacin Isolated from Asimina triloba

Journal of natural products, v.81 no.8, 2018년, pp.1905 - 1909  

Monsen, Paige J. (Department of Chemistry , University of Louisville , 2320 South Brook Street , Louisville , Kentucky 40292 , United States) ,  Luzzio, Frederick A.

Abstract AI-Helper 아이콘AI-Helper

Annonacin (1) was isolated from the North American pawpaw (Asimina triloba), as reported earlier from these laboratories. Natural 1 was submitted to the rat aortic ring bioassay for evaluation of antiangiogenic activity and was found to inhibit microvessel growth (IC50 value of 3 μM). 4,10,15,20-...

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