최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기PLoS neglected tropical diseases, v.12 no.8, 2018년, pp.e0006715 -
Kao, Jo-Chi (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) , HuangFu, Wei-Chun (Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan) , Tsai, Tsung-Ting (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) , Ho, Min-Ru (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) , Jhan, Ming-Kai (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) , Shen, Ting-Jing (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) , Tseng, Po-Chun (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) , Wang, Yung-Ting (Department of Microbiology and Immunology, School of Medicine, College of Medicine) , Lin, Chiou-Feng
BackgroundThe antiparasitic agent niclosamide has been demonstrated to inhibit the arthropod-borne Zika virus. Here, we investigated the antiviral capacity of niclosamide against dengue virus (DENV) serotype 2 infection in vitro and in vivo.Principle findingNiclosamide effectively retarded DENV-indu...
1 Bhatt S , Gething PW , Brady OJ , Messina JP , Farlow AW , Moyes CL , et al The global distribution and burden of dengue . Nature . 2013 ; 496 ( 7446 ): 504 – 7 . 10.1038/nature12060 ; PubMed Central PMCID: PMCPMC3651993. 23563266
2 Apte-Sengupta S , Sirohi D , Kuhn RJ . Coupling of replication and assembly in flaviviruses . Curr Opin Virol . 2014 ; 9 : 134 – 42 . 10.1016/j.coviro.2014.09.020 ; PubMed Central PMCID: PMCPMC4268268. 25462445
3 Gebhard LG , Filomatori CV , Gamarnik AV . Functional RNA elements in the dengue virus genome . Viruses . 2011 ; 3 ( 9 ): 1739 – 56 . 10.3390/v3091739 ; PubMed Central PMCID: PMCPMC3187688. 21994804
4 Yacoub S , Mongkolsapaya J , Screaton G . Recent advances in understanding dengue . F1000Res . 2016 ; 5 doi: 10.12688/f1000research.6233.1 ; PubMed Central PMCID: PMCPMC4754027. 26918159
5 Wang YM , Lu JW , Lin CC , Chin YF , Wu TY , Lin LI , et al Antiviral activities of niclosamide and nitazoxanide against chikungunya virus entry and transmission . Antiviral Res . 2016 ; 135 : 81 – 90 . 10.1016/j.antiviral.2016.10.003 . 27742486
6 Xu M , Lee EM , Wen Z , Cheng Y , Huang WK , Qian X , et al Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen . Nat Med . 2016 ; 22 ( 10 ): 1101 – 7 . 10.1038/nm.4184 ; PubMed Central PMCID: PMCPMC5386783. 27571349
7 Li Z , Brecher M , Deng YQ , Zhang J , Sakamuru S , Liu B , et al Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction . Cell Res . 2017 ; 27 ( 8 ): 1046 – 64 . 10.1038/cr.2017.88 ; PubMed Central PMCID: PMCPMC5539352. 28685770
8 Huang L , Yang M , Yuan Y , Li X , Kuang E . Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation . Antiviral Res . 2017 ; 138 : 68 – 78 . 10.1016/j.antiviral.2016.12.002 . 27939840
9 Li Y , Li PK , Roberts MJ , Arend RC , Samant RS , Buchsbaum DJ . Multi-targeted therapy of cancer by niclosamide: A new application for an old drug . Cancer Lett . 2014 ; 349 ( 1 ): 8 – 14 . 10.1016/j.canlet.2014.04.003 ; PubMed Central PMCID: PMCPMC4166407. 24732808
10 Chen W , Mook RA, Jr. , Premont RT , Wang J . Niclosamide: Beyond an antihelminthic drug . Cell Signal . 2018 ; 41 : 89 – 96 . 10.1016/j.cellsig.2017.04.001 ; PubMed Central PMCID: PMCPMC5628105. 28389414
11 Diehl N , Schaal H . Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway . Viruses . 2013 ; 5 ( 12 ): 3192 – 212 . 10.3390/v5123192 ; PubMed Central PMCID: PMCPMC3967167. 24351799
12 Jordan TX , Randall G . Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy . J Virol . 2017 ; 91 ( 11 ). 10.1128/JVI.02020-16 ; PubMed Central PMCID: PMCPMC5432877. 28298606
13 Heaton NS , Randall G . Dengue virus-induced autophagy regulates lipid metabolism . Cell Host Microbe . 2010 ; 8 ( 5 ): 422 – 32 . 10.1016/j.chom.2010.10.006 ; PubMed Central PMCID: PMCPMC3026642. 21075353
14 Smit JM , Moesker B , Rodenhuis-Zybert I , Wilschut J . Flavivirus cell entry and membrane fusion . Viruses . 2011 ; 3 ( 2 ): 160 – 71 . 10.3390/v3020160 ; PubMed Central PMCID: PMCPMC3206597. 22049308
15 Rogers DM , Kent MS , Rempe SB . Molecular basis of endosomal-membrane association for the dengue virus envelope protein . Biochim Biophys Acta . 2015 ; 1848 ( 4 ): 1041 – 52 . 10.1016/j.bbamem.2014.12.018 . 25559317
16 Mosso C , Galvan-Mendoza IJ , Ludert JE , del Angel RM . Endocytic pathway followed by dengue virus to infect the mosquito cell line C6/36 HT . Virology . 2008 ; 378 ( 1 ): 193 – 9 . 10.1016/j.virol.2008.05.012 . 18571214
17 Ho MR , Tsai TT , Chen CL , Jhan MK , Tsai CC , Lee YC , et al Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways . Sci Rep . 2017 ; 7 ( 1 ): 6910 10.1038/s41598-017-07023-z ; PubMed Central PMCID: PMCPMC5537343. 28761128
18 Kang S , Shields AR , Jupatanakul N , Dimopoulos G . Suppressing dengue-2 infection by chemical inhibition of Aedes aegypti host factors . PLoS Negl Trop Dis . 2014 ; 8 ( 8 ): e3084 10.1371/journal.pntd.0003084 ; PubMed Central PMCID: PMCPMC4125141. 25101828
19 Jurgeit A , McDowell R , Moese S , Meldrum E , Schwendener R , Greber UF . Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects . PLoS Pathog . 2012 ; 8 ( 10 ): e1002976 10.1371/journal.ppat.1002976 ; PubMed Central PMCID: PMCPMC3486884. 23133371
20 Tsai TT , Chen CL , Lin YS , Chang CP , Tsai CC , Cheng YL , et al Microglia retard dengue virus-induced acute viral encephalitis . Sci Rep . 2016 ; 6 : 27670 10.1038/srep27670 ; PubMed Central PMCID: PMCPMC4899773. 27279150
21 Zhang S , Tan HC , Ooi EE . Visualizing dengue virus through Alexa Fluor labeling . J Vis Exp . 2011 ;( 53 ): e3168 10.3791/3168 ; PubMed Central PMCID: PMCPMC3196179. 21775958
22 Sanchez-Vargas I , Scott JC , Poole-Smith BK , Franz AW , Barbosa-Solomieu V , Wilusz J , et al Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway . PLoS Pathog . 2009 ; 5 ( 2 ): e1000299 10.1371/journal.ppat.1000299 ; PubMed Central PMCID: PMCPMC2633610. 19214215
23 Kim DH , Sarbassov DD , Ali SM , King JE , Latek RR , Erdjument-Bromage H , et al mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery . Cell . 2002 ; 110 ( 2 ): 163 – 75 . . 12150925
24 Oshiro N , Yoshino K , Hidayat S , Tokunaga C , Hara K , Eguchi S , et al Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function . Genes Cells . 2004 ; 9 ( 4 ): 359 – 66 . 10.1111/j.1356-9597.2004.00727.x . 15066126
25 Lee YR , Hu HY , Kuo SH , Lei HY , Lin YS , Yeh TM , et al Dengue virus infection induces autophagy: an in vivo study . J Biomed Sci . 2013 ; 20 : 65 10.1186/1423-0127-20-65 ; PubMed Central PMCID: PMCPMC3848819. 24011333
26 Fonseca BD , Diering GH , Bidinosti MA , Dalal K , Alain T , Balgi AD , et al Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling . J Biol Chem . 2012 ; 287 ( 21 ): 17530 – 45 . 10.1074/jbc.M112.359638 ; PubMed Central PMCID: PMCPMC3366846. 22474287
27 Wu CJ , Jan JT , Chen CM , Hsieh HP , Hwang DR , Liu HW , et al Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide . Antimicrob Agents Chemother . 2004 ; 48 ( 7 ): 2693 – 6 . 10.1128/AAC.48.7.2693-2696.2004 ; PubMed Central PMCID: PMCPMC434198. 15215127
28 Alam A , Imam N , Farooqui A , Ali S , Malik MZ , Ishrat R . Recent trends in ZikV research: A step away from cure . Biomed Pharmacother . 2017 ; 91 : 1152 – 9 . 10.1016/j.biopha.2017.05.045 . 28531943
29 Kato F , Hishiki T . Dengue Virus Reporter Replicon is a Valuable Tool for Antiviral Drug Discovery and Analysis of Virus Replication Mechanisms . Viruses . 2016 ; 8 ( 5 ). 10.3390/v8050122 ; PubMed Central PMCID: PMCPMC4885077. 27164125
30 Lin KH , Ali A , Rusere L , Soumana DI , Kurt Yilmaz N , Schiffer CA . Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side . J Virol . 2017 ; 91 ( 10 ). 10.1128/JVI.00045-17 ; PubMed Central PMCID: PMCPMC5411607. 28298600
31 Wu H , Bock S , Snitko M , Berger T , Weidner T , Holloway S , et al Novel dengue virus NS2B/NS3 protease inhibitors . Antimicrob Agents Chemother . 2015 ; 59 ( 2 ): 1100 – 9 . 10.1128/AAC.03543-14 ; PubMed Central PMCID: PMCPMC4335830. 25487800
32 Yang CC , Hu HS , Wu RH , Wu SH , Lee SJ , Jiaang WT , et al A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease . Antimicrob Agents Chemother . 2014 ; 58 ( 1 ): 110 – 9 . 10.1128/AAC.01281-13 ; PubMed Central PMCID: PMCPMC3910792. 24145533
33 Shiryaev SA , Farhy C , Pinto A , Huang CT , Simonetti N , Ngono AE , et al Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists . Antiviral Res . 2017 ; 143 : 218 – 29 . 10.1016/j.antiviral.2017.04.015 ; PubMed Central PMCID: PMCPMC5558795. 28461069
34 Duan X , Lu X , Li J , Liu Y . Novel binding between pre-membrane protein and vacuolar ATPase is required for efficient dengue virus secretion . Biochem Biophys Res Commun . 2008 ; 373 ( 2 ): 319 – 24 . 10.1016/j.bbrc.2008.06.041 . 18573235
35 Hoopmann P , Punge A , Barysch SV , Westphal V , Buckers J , Opazo F , et al Endosomal sorting of readily releasable synaptic vesicles . Proc Natl Acad Sci U S A . 2010 ; 107 ( 44 ): 19055 – 60 . 10.1073/pnas.1007037107 ; PubMed Central PMCID: PMCPMC2973917. 20956291
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.