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The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR

PLoS neglected tropical diseases, v.12 no.8, 2018년, pp.e0006715 -   

Kao, Jo-Chi (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) ,  HuangFu, Wei-Chun (Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan) ,  Tsai, Tsung-Ting (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) ,  Ho, Min-Ru (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) ,  Jhan, Ming-Kai (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) ,  Shen, Ting-Jing (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) ,  Tseng, Po-Chun (Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan) ,  Wang, Yung-Ting (Department of Microbiology and Immunology, School of Medicine, College of Medicine) ,  Lin, Chiou-Feng

Abstract AI-Helper 아이콘AI-Helper

BackgroundThe antiparasitic agent niclosamide has been demonstrated to inhibit the arthropod-borne Zika virus. Here, we investigated the antiviral capacity of niclosamide against dengue virus (DENV) serotype 2 infection in vitro and in vivo.Principle findingNiclosamide effectively retarded DENV-indu...

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