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Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness 원문보기

Clinical Cancer research : an official journal of the American Association for Cancer Research, v.25 no.4, 2019년, pp.1415 - 1429  

Park, So-Yeon (School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.) ,  Kim, Ji-Young (Laboratory Animal Resource Center, Gwangju Institute of Science and Technology, Gwnagju, Republic of Korea.) ,  Choi, Jang-Hyun (School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.) ,  Kim, Jee-Heun (School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.) ,  Lee, Choong-Jae (School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.) ,  Singh, Pomila (Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas.) ,  Sarkar, Shubhashish (Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas.) ,  Baek, Jeong-Heum (Division of Colon and Rectal Surgery, Department of Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.) ,  Nam, Jeong-Seok (School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.)

Abstract AI-Helper 아이콘AI-Helper

Purpose:Niclosamide, an FDA-approved anthelmintic drug, has been characterized as a potent Wnt inhibitor that can suppress tumor growth and cancer stem-like cell (CSC) populations. However, the underlying molecular mechanisms remain poorly understood. This study aimed to examine how Wnt inhibition b...

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