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Olive oil inhibits ageing signs induced by chronic stress in ex vivo human skin via inhibition of extracellular‐signal‐related kinase 1/2 and c‐JUN pathways

International journal of cosmetic science, v.41 no.2, 2019년, pp.156 - 163  

Romana‐Souza, B. (Laboratory of Tissue Repair, Department of Histology and Embryology, State University of Rio de Janeiro, Rio de Janeiro, RJ, 20950‐) ,  Monte‐Alto‐Costa, A. (003, Brazil)

Abstract AI-Helper 아이콘AI-Helper

AbstractObjectiveChronic stress‐induced oxidative damage and protease synthesis cause a loss of extracellular matrix components promoting human skin ageing. The administration of antioxidant compounds, such as those observed in olive oil, may attenuate stress‐induced ageing signs in huma...

Abstract

RésuméOBJECTIFLe dommage oxydatif chronique induit par le stress et la synthèse de protéases entraînent une dégradation des composants de la matrice extracellulaire favorisant le vieillissement de la peau humaine. L'administration de composés antioxydants, tels que ceux observés dans l'huile d'olive, peut atténuer les signes de vieillissement induits par le stress sur la peau humaine. L'objectif de cette étude était donc d’étudier l'effet de l'administration d'huile d'olive sur une peau humaine stressée ex vivo.MÉTHODESDes explants de peau humaine ont été traités avec des niveaux élevés d’épinéphrine (comme observé chez les patients stressés) et d'huile d'olive dans un milieu pendant 13 jours. Les cultures traitées avec le milieu seul ont été utilisées comme témoins.RÉSULTATSL'huile d'olive a renversé la réduction de l’épaisseur de l’épiderme et du derme et des fibres de collagène, induite par le niveau élevé d’épinéphrine dans la peau humaine ex vivo. L'augmentation de la production d'espèces réactives de l'oxygène (ROS) et de malondialdéhyde (indice de péroxydation lipidique) favorisée par des taux élevés d’épinéphrine a également été atténuée par l'huile d'olive dans la peau humaine ex vivo. En outre, l'huile d'olive a pu inverser l'augmentation, induite par le niveau élevé d’épinéphrine, de la phosphorylation de la kinase liée au signal extracellulaire 1/2 (ERK 1/2) et c‐JUN (un composant majeur du facteur de transcription AP‐1) et de la expression de la métalloprotéinase matricielle protéique‐2 (MMP‐2) dans la peau humaine ex vivo.CONCLUSIONL'huile d'olive atténue les signes du vieillissement induit par le stress (mincissement du derme et perte de fibres de collagène) dans la peau humaine ex vivo en réduisant l'expression de MMP‐2, la production de ROS et la phosphorylation de ERK 1/2 et de cJUN.

주제어

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