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Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains 원문보기

Journal of neurochemistry, v.150 no.6, 2019년, pp.776 - 786  

Jin, Chunmei (Departments of Neuroscience, College of Medicine, Korea University, Seoul, South Korea) ,  Kim, Shinhyun (Departments of Neuroscience, College of Medicine, Korea University, Seoul, South Korea) ,  Kang, Hyojin (Division of National Supercomputing, KISTI, Daejeon, South Korea) ,  Yun, Ki Na (Biomedical Omics Group, Korea Basic Science Institute, Ochang, Korea) ,  Lee, Yeunkum (Departments of Neuroscience, College of Medicine, Korea University, Seoul, South Korea) ,  Zhang, Yinhua (Departments of Neuroscience, College of Medicine, Korea University, Seoul, South Korea) ,  Kim, Yoonhee (Departments of Neuroscience, College of Medicine, Korea University, Seoul, South Korea) ,  Kim, Jin Young (Biomedical Omics Group, Korea Basic Science Institute, Ochang, Korea) ,  Han, Kihoon (Departments of Neuroscience, College of Me)

Abstract AI-Helper 아이콘AI-Helper

AbstractThe SH3 and multiple ankyrin repeat domains 3 (Shank3) proteins are core organizers of the postsynaptic density in neuronal excitatory synapses, and their defects cause various neurodevelopmental and neuropsychiatric disorders. Mechanistically, Shank3 directly and indirectly interacts with h...

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