$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Eckol from Ecklonia cava ameliorates TNF-α/IFN-γ-induced inflammatory responses via regulating MAPKs and NF-κB signaling pathway in HaCaT cells

International immunopharmacology, v.82, 2020년, pp.106146 -   

Cho, Su-Hyeon (Chuncheon Center, Korea Basic Science Institute (KBSI)) ,  Kim, Hyun-Soo (National Marine Biodiversity Institute of Korea) ,  Lee, WonWoo (Frechwater Biosources Utilization Bureau, Bioresources Industrialization Support Division, Nakdonggang National Institute of Biological Resources (NNIBR)) ,  Han, Eui Jeong (Department of Food Technology and Nutrition, Chonnam National University) ,  Kim, Seo-Young (Chuncheon Center, Korea Basic Science Institute (KBSI)) ,  Fernando, I.P. Shanura (Department of Food Technology and Nutrition, Chonnam National University) ,  Ahn, Ginnae (Department of Food Technology and Nutrition, Chonnam National University) ,  Kim, Kil-Nam (Chuncheon Center, Korea Basic Science Institute (KBSI))

Abstract AI-Helper 아이콘AI-Helper

Abstract We investigated the protective effect of the bioactive compound eckol on inflammatory-related skin lesions in vitro. HaCaT cells were stimulated with tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) mixture, and treated with various concentration of eckol (25, 5...

주제어

참고문헌 (60)

  1. N. Engl. J. Med. Robert 341 24 1817 1999 10.1056/NEJM199912093412407 Inflammatory skin diseases, T cells, and immune surveillance 

  2. J. Ethnopharmacol. Kim 122 1 129 2009 10.1016/j.jep.2008.12.011 Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocytes HaCaT cells 

  3. Postepy dermatologii i alergologii Nedoszytko 31 2 84 2014 10.5114/pdia.2014.40920 Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: atopic dermatitis, psoriasis and skin mastocytosis 

  4. J. Interferon Cytokine Res. Fujisawa 17 12 721 1997 10.1089/jir.1997.17.721 The expression and modulation of IFN-α and IFN-β in human keratinocytes 

  5. J. Clin. Cell. Immunol. Brandt 2 3 110 2011 10.4172/2155-9899.1000110 Th2 cytokines and atopic dermatitis 

  6. Food Chem. Toxicol. Lim 63 212 2014 10.1016/j.fct.2013.10.050 Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice 

  7. Algae Lee 30 2 163 2015 10.4490/algae.2019.34.6.4 Cellular activities and docking studies of eckol isolated from Ecklonia cava (Laminariales, Phaeophyceae) as potential tyrosinase inhibitor 

  8. Eur. Food Res. Technol. Ahn 226 1 71 2007 10.1007/s00217-006-0510-y Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage 

  9. BioFactors Wijesekara 36 6 408 2010 10.1002/biof.114 Phlorotannins from Ecklonia cava (Phaeophyceae): Biological activities and potential health benefits 

  10. Life Sci. Kim 79 15 1436 2006 10.1016/j.lfs.2006.04.022 Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity 

  11. Carbohydr. Polym. Lee 92 1 84 2013 10.1016/j.carbpol.2012.09.066 Anti-inflammatory effect of fucoidan extracted from Ecklonia cava in zebrafish model 

  12. Phytochem. Lett. Pádua 14 91 2015 10.1016/j.phytol.2015.09.007 Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer 

  13. FEBS Lett. Kang 579 28 6295 2005 10.1016/j.febslet.2005.10.008 Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells 

  14. FEBS Lett. Park 582 6 925 2008 10.1016/j.febslet.2008.02.031 Radioprotective properties of eckol against ionizing radiation in mice 

  15. Biochem. Biophys. Res. Commun. Park 372 4 792 2008 10.1016/j.bbrc.2008.05.140 Modulation of apoptosis of eckol against ionizing radiation in mice 

  16. J. Food Biochem. Eom 41 2 2017 10.1111/jfbc.12312 Eckol from Eisenia bicyclis Inhibits Inflammation Through the Akt/NF-κB Signaling in Propionibacterium acnes-Induced Human Keratinocyte Hacat Cells 

  17. Eur. Food Res. Technol. Ahn 226 1 71 2007 10.1007/s00217-006-0510-y Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage 

  18. Process Biochem. Li 46 12 2219 2011 10.1016/j.procbio.2011.09.015 Phlorotannins as bioactive agents from brown algae 

  19. Phytomedicine Yang 22 14 1262 2015 10.1016/j.phymed.2015.09.006 Ethanol extracts of Sanguisorba officinalis L. suppress TNF-α/IFN-γ-induced pro-inflammatory chemokine production in HaCaT cells 

  20. 10.1016/j.intimp.2015.10.023 Icariin inhibits TNF-α/IFN-γ induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes, Int. Immunopharmacol. 29(2) (2015) 401-407. 

  21. J. Ethnopharmacol. Park 171 85 2015 10.1016/j.jep.2015.05.039 Xanthii fructus extract inhibits TNF-α/IFN-γ-induced Th2-chemokines production via blockade of NF-κB, STAT1 and p38-MAPK activation in human epidermal keratinocytes 

  22. Biochem. Biophys. Res. Commun. Jung 427 2 236 2012 10.1016/j.bbrc.2012.08.087 Suppression of thymus- and activation-regulated chemokine (TARC/CCL17) production by 3-O-β-d-glucopyanosylspinasterol via blocking NF-κB and STAT1 signaling pathways in TNF-α and IFN-γ-induced HaCaT keratinocytes 

  23. J. Ethnopharmacol. Sung 144 1 182 2012 10.1016/j.jep.2012.08.049 Illicium verum extract inhibits TNF-α- and IFN-γ-induced expression of chemokines and cytokines in human keratinocytes 

  24. Biochem. Biophys. Res. Commun. Ju 387 1 115 2009 10.1016/j.bbrc.2009.06.137 Suppression of thymus- and activation-regulated chemokine (TARC/CCL17) production by 1,2,3,4,6-penta-O-galloyl-β-d-glucose via blockade of NF-κB and STAT1 activation in the HaCaT cells 

  25. Immunity Hammad 43 1 29 2015 10.1016/j.immuni.2015.07.007 Barrier epithelial cells and the control of Type 2 immunity 

  26. 10.1073/pnas.1714348115 S. Ochiai, F. Jagot, R.L. Kyle, E. Hyde, R.F. White, M. Prout, A.J. Schmidt, H. Yamane, O. Lamiable, G. Le Gros, F. Ronchese, Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells, Proc. Natl. Acad. Sci. 115(5) (2018) 1033-1038. 

  27. Curr. Opin. Allergy Clin. Immunol. Divekar 15 1 98 2015 10.1097/ACI.0000000000000133 Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation 

  28. Fibrosis Vannella 8 337 337ra65 2016 Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis 

  29. Immune Network Kim 18 2 2018 10.4110/in.2018.18.e9 Optimization of cytokines milieu to reproduce atopic dermatitis-related gene expression in HaCaT keretinocyte cell line 

  30. J, Invest. Dermatol. Cevikbas 132 5 1326 2012 10.1038/jid.2012.66 IL-33: A novel danger signal system in atopic dermatitis 

  31. 10.4049/jimmunol.1700216 M. Han, C. Rajput, J.Y. Hong, J. Lei, J.L. Hinde, Q. Wu, J.K. Bentley, M.B. Hershenson, The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice, J. Immunol. (Baltimore, Md.: 1950) 199(4) (2017) 1308-1318. 

  32. Int. Immunol. Louten 23 5 307 2011 10.1093/intimm/dxr006 Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation 

  33. Immunity Lüthi 31 1 84 2009 10.1016/j.immuni.2009.05.007 Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases 

  34. Eur. J. Pharmacol. Nabe 757 34 2015 10.1016/j.ejphar.2015.03.015 Production of interleukin (IL)-33 in the lungs during multiple antigen challenge-induced airway inflammation in mice, and its modulation by a glucocorticoid 

  35. J. Exp. Med. Yoo 202 4 541 2005 10.1084/jem.20041503 Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin 

  36. Expert Rev. Proteomics Indra 10 4 309 2013 10.1586/14789450.2013.814881 Epidermal TSLP: a trigger factor for pathogenesis of atopic dermatitis 

  37. J. Invest. Dermatol. Hvid 131 1 150 2011 10.1038/jid.2010.277 IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction? 

  38. Immunity Fort 15 6 985 2001 10.1016/S1074-7613(01)00243-6 IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo 

  39. J. Allergy Clin. Immunol. Benson 106 2 307 2000 10.1067/mai.2000.108111 Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-γ, IL-1β, TNF-α, or neutrophils 

  40. Arch. Dermatol. Res. Kaburagi 293 7 350 2001 10.1007/s004030100230 Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1α, MIP-1β, and eotaxin) in patients with atopic dermatitis 

  41. Immunol. Today Mantovani 20 6 254 1999 10.1016/S0167-5699(99)01469-3 The chemokine system: redundancy for robust outputs 

  42. Nat. Product Sci. Ryu 21 3 205 2015 Anti-inflammatory activity of fucoidan with blocking NF-κB and STAT1 in human keratinocytes cells 

  43. Vet. Immunol. Immunopathol. Gro¨ne 88 1-2 1 2002 10.1016/S0165-2427(02)00136-8 Keratinocytes and cytokines 

  44. J. Immunol. Nelson 151 5 2601 1993 10.4049/jimmunol.151.5.2601 Genomic organization and transcriptional regulation of the RANTES chemokine gene 

  45. Arch. Dermatol. Res. Zhang 300 10 575 2008 10.1007/s00403-008-0872-z Effects of acitretin on proliferative inhibition and RANTES production of HaCaT cells 

  46. Clin. Exp. Immunol. Jean-Baptiste 127 3 470 2002 10.1046/j.1365-2249.2002.01755.x Expression of eotaxin, an eosinophil-selective chemokine, parallels eosinophil accumulation in the vesiculobullous stage of incontinentia pigmenti 

  47. Immunity Gonzalo 4 1 1 1996 10.1016/S1074-7613(00)80293-9 Mouse Eotaxin Expression Parallels Eosinophil Accumulation during Lung Allergic Inflammation but It Is Not Restricted to a Th2-Type Response 

  48. J. Exp. Med. Rothenberg 185 4 785 1997 10.1084/jem.185.4.785 Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia 

  49. Am. J. Respir. Cell Mol. Biol. Rothenberg 21 3 291 1999 10.1165/ajrcmb.21.3.f160 Eotaxin 

  50. Invest. Ophthalmol. Vis. Sci. Kumagai 41 6 1448 2000 Synergistic induction of eotaxin expression in human keratocytes by TNF-α and IL-4 or IL-13 

  51. Cold Spring Harbor protocols Rio 2014 11 1207 2014 10.1101/pdb.prot080887 Reverse transcription-polymerase chain reaction 

  52. 10.1038/s41598-017-14365-1 N.N. Mehta, H.L. Teague, W.R. Swindell, Y. Baumer, N.L. Ward, X. Xing B. Baugous, A. Johnston, A.A. Joshi, J. Silverman, D.H. Barnes, L. Wolterink, R.P. Nair, P.E. Stuart, M. Playford, J.J. Voorhees, M.K. Sarkar, J.T. Elder, K. Gallagher, S.K. Ganesh, J.E. Gudjonsson, IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis, Sci. Reports 7(1) (2017) 13831. 

  53. Crit. Care Med. Arbabi 30 1 S74 2002 10.1097/00003246-200201001-00010 Mitogen-activated protein kinases 

  54. Int. Immunopharmacol. Lim 56 135 2018 10.1016/j.intimp.2018.01.025 Effect of peiminine on DNCB-induced atopic dermatitis by inhibiting inflammatory cytokine expression in vivo and in vitro 

  55. Toxicol. In Vitro Dillman 18 5 593 2004 10.1016/j.tiv.2004.01.009 An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes 

  56. Shock Ipaktchi 26 2 201 2006 10.1097/01.shk.0000225739.13796.f2 Topical p38MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn wounds 

  57. Cardiovasc. Toxicol. Brasier 6 2 111 2006 10.1385/CT:6:2:111 The NF-κB regulatory network 

  58. Cell Baeuerle 87 1 13 1996 10.1016/S0092-8674(00)81318-5 NF-κB: Ten Years After 

  59. Nat. Rev. Immunol. Li 2 10 725 2002 10.1038/nri910 NF-κB regulation in the immune system 

  60. FEMS Microbiol. Ecol. Smith 67 1 6 2009 10.1111/j.1574-6941.2008.00629.x Advantages and limitations of quantitative PCR (Q-PCR)-based approaches in microbial ecology 

LOADING...

관련 콘텐츠

유발과제정보 저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로