IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0401380
(1973-09-27)
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우선권정보 |
LU-0066207 (1972-09-29) |
발명자
/ 주소 |
- Bouillon Claude (Eaubonne FR) Vayssie Charles (Aulnay-sous-Bois FR)
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출원인 / 주소 |
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인용정보 |
피인용 횟수 :
22 인용 특허 :
0 |
초록
▼
A method and composition for combatting the greasy and unaesthetic appearance of the hair and to improve the appearance of the skin comprises in a carrier at least one active component of the formula R1 R-S-CH2-CH-CH2-N�2 wherein R1 and R2 are methyl, ethyl, isopropyl, cyclohexyl, benzyl or b1 and R
A method and composition for combatting the greasy and unaesthetic appearance of the hair and to improve the appearance of the skin comprises in a carrier at least one active component of the formula R1 R-S-CH2-CH-CH2-N�2 wherein R1 and R2 are methyl, ethyl, isopropyl, cyclohexyl, benzyl or b1 and R2 taken together form -(CH2)2-(CH2)2-, -(CH2)2-CH2-(CH2)2-, -(CH2)2-O-(CH2)2-, -(CH2)2-N-(CH2)2-, │ CH3 or -(CH2)2-N-(CH2)2-; │ C6H5 ; and R is (1) linear or branched alkyl having 1-18 carbon atoms, (ii) alkenyl having 3-18 carbon atoms, (iii) alkyl having 2-3 carbon atoms and substituted by 1-2 alcohol functions, (iv) -(CH2)m-CH(OR3)2 wherein R3 is alkyl having 1-4 carbon atoms and m is 1-2, (v) -(CH2)nR4 wherein n is 0, 1 or 2 and R4 is 2 -pyridyl or phenyl, (vi) -(CH2)qR′4 wherein q is 0 or 1 and R′4 is 1-naphthyl, 2-naphthyl WHEREIN P IS 1, 2 OR 3 IN WHICH INSTANCE R5 is F, Cl, Br, alkoxy having 1-5 carbon atoms or alkyl having 1-4 carbon atoms, or wherein p is 1 in which instance R5 is amino, dimethylamino and methylenedioxy, (vii) -CH(C6H5)2, (viii) -C(C6H5)3, (ix) -CH(C6H4p-OCH3)2, (x) -CH2-CH-NH2, │ COOH (xi) -CH2-CH2-NH-Y wherein Y is hydrogen, nicotinyl or COR9 wherein R9 is hydrogen, alkyl having 1-18 carbon atoms, alkenyl having 2-18 carbon atoms WHEREIN R11 is H, F, Cl, Br or alkoxy having 1-4 carbon atoms, (xii) -CH-COOH │ CH2-COOH, and (xiii) -(CH2)s-COOH wherein s is 1-10. The present invention relates to cosmetic compositions which when administered orally or topically -a human being having hair, skin or scalp characterized by a greasy and unaesthetic appearance significantly improves the condition and appearance of the hair, scalp and skin by essentially eliminating this greasy and unaesthetic appearance. This condition of a greasy and unaesthetic appearance of the hair, skin and scalp can be occasioned by excessive secrEtions of the sebaceous glands and the compositions of this invention are useful in diminishing such excessive secretions. The compositions are also useful to combat dandruff. It has already been proposed for use in combatting against the greasy appearance of the hair as well as against the unaesthetic appearance of the skin certain S-substituted derivatives of cysteine and cysteamine. However, after further investigation, it has now been found that by using as the active component a hydroxylated amino thioether, an activity greater than that of previously known compounds for combatting against a greasy and unaesthetic appearance of the hair and skin is achieved. MOreover, it has been established that these hydroxylated amino thioethers exhibit excellent solubility in water and hydro-alcoholic solutions, a characteristic which permits the realization of many different types of cosmetic formulations. This solubility feature is due in particular to the presence of a hydroxyl group in the molecule of these active compounds. Consequently, relative to the previously known compounds, the active compounds of the present invention, exhibit increased activity and better solubility in water, alcohol and hydroalcoholic solutions. The present invention has for an object a new composition for combatting against the greasy and unaesthetic appearance of the hair and to improve the appearance of the skin, characterized by the fact that it contains in combination in an appropriate carrier, at least one active compound of the formula R1 R-S-CH2-CH-CH2-N�2 wherein: R1 and R2 each independently, are selected from the group consisting of methyl, ethyl, isopropyl, cyclohexyl, benzyl and B-hydroxyethyl, or R1 and R2 taken together form a divalent radical selected from the group consisting of -(CH2)2-(CH2)2-,-(CH2)2-CH2-(CH2)2-, -(CH2)2-O-(CH2)2-, -(CH2)2-N-(CH2)2- and -(CH2)2-N-(CH2)2-; │ │ CH3 C6H5 an R is selected from the group consisting of: i. linear or branched alkyl having 1-18 carbon atoms, ii. alkenyl having 3-18 carbon atoms, iii. alkyl having 2-3 carbon atoms and substituted by 1-2 alcohol functions, i.e., OH groups, iv. -(CH2)m-CH(OR3)2 wherein R3 is alkyl having 1-4 carbon atoms and m is 1-2, v. -(CH2)nR4 wherein n is 0, 1 or 2 and R4 is selected from the group consisting of 2-pyridyl and phenyl, vi. -(CH2)q R′4 wherein q is 0 or 1 and R′4 is selected from the group consisting of 1-naphthyl, 2-naphthyl and wherein p is 1, 2 or 3 in which instance R5 is selected from the group consisting of F, Cl, Br, alkoxy having 1-5 carbon atoms and alkyl having 1-4 carbon atoms, or wherein p is 1 in which instance R5 is selected from the group consisting of amino, dimethylamino and methylenedioxy, vii -CH(C6H5)2, viii -C(C6H5)3, ix -CH(C6H4p-OCH3)2, x -CH2-CH-NH2, │ COOH xi. -CH2-CH2-NH-Y wherein Y is selected from the group consisting of hydrogen, nicotinyl and COR9 wherein R9 is selected from the group consisting of hydrogen, alkyl haVing 1-18 carbon atoms, alkenyl having 2-18 carbon atoms and wherein R11 is selected from the group consisting of H, F, Cl, Br and alkoxy having 1-4 carbon atoms, xii -CH-COOH │ CH2-COOH and xiii. -(CH2)s-COOH wherein s is 1-10. In one preferred embodiment of the present invention, the active compound has the formula R1 R-S-CH2-CH-CH2-N�2 wherein R1 and R2 have the meanings given above and R is selected from the group consisting of i -(CH2)s-COOH wherein s is 1-10, ii -CH2-CH-COOH and │ NH2 iii -CH-COOH │ CH2-COOH In another preferred embodiment the active compound has the formula R1 R-S-CH2-CH-CH2N�2 wherein R1 and R2 have the meanings given above and R is selected from the group consisting of i. alkyl having 1-18 carbon atoms, ii. alkenyl having 3-18 carbon atoms, iii. alkyl having 2-3 carbon atoms and substituted by 1-2 OH groups, OR3 iv -(CH2)m-CH
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