Aluminum-zirconium anti-perspirant systems with hydroxy carboxylic compounds
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-007/00
A61K-009/00
출원번호
US-0433931
(1974-01-16)
발명자
/ 주소
Rubino Andrew M. (New Providence NJ)
출원인 / 주소
Armour Pharmaceutical Company (Phoenix AZ 02)
인용정보
피인용 횟수 :
23인용 특허 :
0
초록▼
Anti-perspirant complexes are provided which comprise a combination of a basic aluminum compound, a zirconium compound and a hydroxy carboxylic compound which may be a non-toxic salt of a hydroxy carboxylic acid, a non-toxic salt of an aluminum chelate of a hydroxy carboxylic acid, a codried mixture
Anti-perspirant complexes are provided which comprise a combination of a basic aluminum compound, a zirconium compound and a hydroxy carboxylic compound which may be a non-toxic salt of a hydroxy carboxylic acid, a non-toxic salt of an aluminum chelate of a hydroxy carboxylic acid, a codried mixture of aluminum hydroxide with a non-toxic salt of an aluminum chelate of a hydroxy carboxylic acid, or mixtures thereof. The various components are present in the complex in amounts such that the Al/Zr mol ratio is about 10:1 to 1:10 and the pH of an aqueous solution containing 5 to 15 weight percent of the complex (based on the oxides of aluminum and zirconium) is at least about 3. The complexes may be used in conventional anti-perspirant forms, including aqueous solutions, aerosol sprays (including powder-in-oil aerosol sprays), as well as creams, lotions and cream sticks.
대표청구항▼
An astringent, water soluble complex formed by reacting in an aqueous solution: a. a basic aluminum compound selected from the group having the general empirical formula: Al2(OH)6-nxAx wherein x may vary from greater than 0 to less than 6, 6-nx is greater than or equal to 0, n is the valence of A, a
An astringent, water soluble complex formed by reacting in an aqueous solution: a. a basic aluminum compound selected from the group having the general empirical formula: Al2(OH)6-nxAx wherein x may vary from greater than 0 to less than 6, 6-nx is greater than or equal to 0, n is the valence of A, and A is selected from the group consisting of halides, nitrate, sulfamate, sulfate and mixtures thereof; b. a zirconium compound selected from trioxodizirconium salts and the group having the general empirical formula: ZrO(OH)2nzBz wherein Z may vary from 0.9 to 2, n is the valence of B, 2-nz is greater than or equal to 0, and B is selected from the group consisting of halides, nitrate, sulfamate, sulfate and mixtures thereof; c. a hydroxy carboxylic compound selected from the group consisting of non-toxic salts of hydroxy carboxylic acids, non-toxic salts of aluminum chelates of hydroxy carboxylic acids, codried mixtures of aluminum hydroxide with non-toxic salts of aluminum chelates of hydroxy carboxylic acids, and mixtures thereof, said hydroxy carboxylic acids having a hydroxyl group alpha and/or beta to the carboxylic acid and being selected from the group consisting of lactic, citric, tartaric, glycolic, gluconic, trihydroxy glutaric, citryl trigluconic, citryl monogluconic, citryl digluconic, malic, tetrahydroxy adipic, and citramalic acids and mixtures thereof; said zirconium and basic aluminum compounds being present in such amounts as to yield an Al/Zr mole ratio of about 10:1 to 1:10, and said hydroxy caboxylic compound being present in such an amount that the pH of a 5 to 15 weight percent (based on the oxides of Al and Zr) aqueous solution of the complex is at least about 3. An anti-perspirant composition comprising an aqueous solution of the complex according to claim 1 wherein said complex is present in an amount such that the total amount of aluminum plus zirconium in the solution, calculated as the oxides, is about 5 to 15 weight percent.
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