초록 ▼

A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a solid drug carrier permeable to th

A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a solid drug carrier permeable to the passage of the drug. The wall is formed in at least a part of a microporous material the pores of which contain a drug release rate controlling medium also permeable to the passage of the drug, but the rate of passage of the drug through the medium is lower than the rate passage of the drug through the solid drug carrier so that drug release by the medium in the microporous wall is the drug release rate controlling step for releasing drug from the drug delivery device.

대표청구항 ▼

A drug delivery device for the continuous administration of a drug at a controlled rate to produce a beneficial result, said device comprising (a) a wall formed of a microporous material having a plurality of micropores with a pore size of 10 angstroms to 100 microns and formed with diffusional cond

A drug delivery device for the continuous administration of a drug at a controlled rate to produce a beneficial result, said device comprising (a) a wall formed of a microporous material having a plurality of micropores with a pore size of 10 angstroms to 100 microns and formed with diffusional conduits through the wall, (b) a reservoir surrounded by the wall comprising a solid carrier containing dissolved and undissolved drug with the carrier permeable to the passage of dissolved drug by diffusion, (c) a medium made of a pharmaceutically Acceptable release rate controlling material housed in the micropores, said drug having a solubility of 1 part drug in 10 to 15,000 parts of medium with the medium permeable to the passage of drug by diffusion but at a lower rate than through the carrier, and (d) wherein drug is metered at a controlled and continuous rate from the device by passage from the carrier and through the medium with release by the medium being the rate controlling step for releasing drug over a prolonged period of time from the device to produce the desired results.