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Fluorescence quenching with immunological pairs in immunoassays 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-021/00
  • G01N-033/16
출원번호 US-0591386 (1975-06-30)
발명자 / 주소
  • Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA)
출원인 / 주소
  • Syva Company (Palo Alto CA 02)
인용정보 피인용 횟수 : 792  인용 특허 : 1

초록

Immunoassays employing antibodies and a fluorescer-quencher (F-Q) chromophoric pair, wherein one or both of the chromophoric pair are bonded to antibodies. Depending on the particular ligand of interest, various reagent combinations can be employed, where the amount of quenching is directly related

대표청구항

A method for determining in an assay solution, the presence of a ligand in an unknown suspected of containing said ligand, said ligand having at least one epitopic site, wherein two chromophores, Ch1 and Ch2, which form a fluorescer-quencher pair are employed as reagents, whereby in said assay solut

이 특허에 인용된 특허 (1)

  1. Rubenstein Kenneth Edward (Palo Alto CA) Leute Richard K. (Sunnyvale CA), Antibody steric hindrance immunoassay with two antibodies.

이 특허를 인용한 특허 (792)

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  • Sammons, Robert D.; Ivashuta, Sergey; Liu, Hong; Wang, Dafu; Feng, Paul C. C.; Kouranov, Andrei Y.; Andersen, Scott E., Method for controlling herbicide-resistant plants.
  • Mehta Harshvardhan B. ; Kurn Nurith, Method for detecting analytes.
  • Young Charles Y. F. ; Tindall Donald J. ; Klee George G., Method for detection of breast cancer.
  • Kevin M. Slawin ; Donald J. Tindall ; Charles Y. F. Young ; Mohammad Saeed Saedi ; Abhay Kumar ; Harry G. Rittenhouse ; Robert L. Wolfert, Method for detection of micrometastatic prostate cancer.
  • Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru M.; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Method for eliciting an immune response to human telomerase reverse transcriptase.
  • Adair, Charles David, Method for extending pregnancy by reducing intraventricular hemorrhaging in patients exhibiting at least one symptom of preeclampsia and eclampsia.
  • Schmitz, Juergen; Buck, David William; Dzionek, Andrzej, Method for isolating BDCA-4+ dendritic cells.
  • Nishino Tomoyoshi (Tokushima JPX), Method for preparing a pancreatic glucagon specific antibody.
  • Larsen, Niels Erik; Søe, Jørn Borch, Method for producing ultra-heat treatment milk.
  • Wassell, Paul; Søe, Jørn Borch; Mikkelsen, Jørn Dalgaard; Kristensen, Anna Cecilie Jentoft, Method for reducing 1,2-diglyceride content of an edible oil.
  • Bardat, Annie; Begin, Edith; Khandoudi, Nassirah; Just, Olivier; Chtourou, Sami; Schmitthaeusler, Roland, Method for stabilising an immunoglobulin G composition in liquid form.
  • Romeo, Tony, Method of altering the expression of csrB to modify the properties of a cell.
  • Tsuji Yasuhiro,JPX ; Kamisango Keiichi,JPX ; Otsuka Mitsuo,JPX, Method of assaying specimen substance by controlling dose of chemiluminescence.
  • Bloomgren, Gary Lewis; Bozic, Carmen; Lee, Sophia; Pace, Amy; Plavina, Tatiana; Subramanyam, Meena, Method of assessing risk of PML.
  • Pease John S. (Los Altos CA) Kirakossian Hrair (San Jose CA) Wagner Daniel B. (Sunnyvale CA) Ullman Edwin F. (Atherton CA), Method of calibration with photoactivatable chemiluminescent matrices.
  • Kappel, Andreas; Rechner, Andreas; Stephan, Sina; Wissel, Thomas, Method of determining inhibitors of coagulation.
  • Williams, Peter, Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Williams, Peter, Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Williams, Peter, Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Williams, Peter, Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Williams, Peter; Taylor, Thomas J.; Williams, Daniel J. B.; Gould, Ian; Hayes, Mark A., Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Williams, Peter; Taylor, Thomas J.; Williams, Daniel J. B.; Gould, Ian; Hayes, Mark A., Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Williams, Peter; Taylor, Thomas J.; Williams, Daniel J. B.; Gould, Ian; Hayes, Mark A., Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Williams, Peter; Williams, Daniel J. B.; Bloom, Linda; Taylor, Thomas J., Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Williams, Peter; Williams, Daniel J. B.; Bloom, Linda; Taylor, Thomas J., Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
  • Roth, Mark, Method of diagnosing autoimmune disease.
  • Merchav, Shoshana; Meretski, Shai, Method of expanding undifferentiated hemopoietic stem cells.
  • Bojsen, Kirsten; Poulsen, Charlotte Horsman; Soe, Jorn Borch, Method of improving dough and bread quality.
  • Hershkovitz, Oren; Bar-Ilan, Ahuva, Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides.
  • Amos Lynn G. (Painted Post NY) Rogers Charles H. (Duxbury MA), Method of measuring degree of partitioning.
  • Merchav, Shoshana; Meretski, Shai; Zipori, Dov; Kadouri, Avinoam, Method of preparing a conditioned medium from a confluent stromal cell culture.
  • Mevorach, Dror, Method of preparing apoptotic monocytes.
  • Madrid, Susan; Lin, Cherry; Zargahi, Masoud Rajabi; Lorentsen, Rikke Høegh; Isaksen, Mai Faurschou; Ward, Michael, Method of producing a lipolytic enzyme.
  • Shu,Wei; Marton,Ira; Siegel,Daniel L.; Ben Ami,Bravdo; Dekel,Mara; Shoseyov,Oded, Method of producing recombinantβ-glucosidase and an aroma spreading plant.
  • Darnell, Robert; Jensen, Kirk; Ule, Jernej, Method of purifying RNA binding protein-RNA complexes.
  • Gazit, Ehud, Method of screening for compounds that disaggregate amyloid aggregates.
  • De Kreij, Arno; Madrid, Susan Mampusti; Mikkelsen, Jørn Dalgaard; Søe, Jørn Borch, Method of using lipid acyltransferase.
  • Kreij, Arno De; Madrid, Susan Mampusti; Mikkelsen, Jørn Dalgaard; Søe, Jørn Borch, Method of using lipid acyltransferase.
  • John W. Hadden, Method to diagnose and monitor cellular immune deficiencies.
  • Quake, Stephen; Volkmuth, Wayne; Unger, Marc, Methods and apparatus for analyzing polynucleotide sequences.
  • Quake,Stephen; Braslavsky,Ido; Hebert,Benedict; Kartalov,Emil, Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension.
  • Quake,Stephen R., Methods and apparatuses for analyzing polynucleotide sequences.
  • Afonina, Irina A.; Belousov, Yevgeniy S., Methods and compositions for detecting antibiotic resistant bacteria.
  • Kurn, Nurith, Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof.
  • Kurn, Nurith, Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof.
  • Kurn, Nurith, Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof.
  • Davis, Noa; Elkeles, Adi; Terkieltaub, Dov; Chausovsky, Alexander, Methods and compositions for identifying a cell phenotype.
  • Buzby,Philip Richard, Methods and compositions for improving fidelity in a nucleic acid synthesis reaction.
  • Neufeld, Gera; Akiri, Gal; Vadasz, Zahava; Gengrinovitch, Stela, Methods and compositions for modulating angiogenesis.
  • Patten Phillip A. ; Stemmer Willem P. C., Methods and compositions for polypeptide engineering.
  • Patten Phillip A. ; Stemmer Willem P.C., Methods and compositions for polypeptide engineering.
  • Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
  • Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
  • Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
  • Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
  • Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptide engineering.
  • Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptide engineering.
  • Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptide engineering.
  • Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptides engineering.
  • Van Antwerp, William P., Methods and compositions for the inhibition of biofilms on medical devices.
  • Kurn, Nurith, Methods and compositions for transcription-based nucleic acid amplification.
  • Smith, Victoria; Ogg, Scott; Van Vlasselaer, Peter; Barry, Vivian E.; Marshall, Derek; Holzer, Alison Kay; Rodriguez, Hector; Oyasu, Miho; McCauley, Scott Alan; Garcia, Carlos Aurelio; Biermann, Donna Hiroko Tokuoka, Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis.
  • Smith, Victoria; Ogg, Scott; Van Vlasselaer, Peter; Barry, Vivian E.; Marshall, Derek; Holzer, Alison Kay; Rodriguez, Hector; Oyasu, Miho; McCauley, Scott Alan; Garcia, Carlos Aurelio; Biermann, Donna Hiroko Tokuoka, Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis.
  • Ader, Daniel; Dimmic, Matt W.; Li, Zhaolong; Sammons, Robert Douglas; Shah, Ronak Hasmukh; Tao, Nengbing; Wang, Dafu, Methods and compositions for weed control.
  • Ader, Daniel; Fiinnessy, John J; Li, Zhaolong; Masucci, James D; Shah, Ronak Hasmukh; Tao, Nengbing; Taylor, Jennifer Chou, Methods and compositions for weed control.
  • Ader, Daniel; Finnessy, John J; Li, Zhaolong; Kapoor, Mahak; Shah, Ronak Hasmukh; Tao, Nengbing; Wang, Dafu, Methods and compositions for weed control.
  • Levy, Efrat, Methods and compositions relating to cystatin C.
  • Huberman, Eliezer, Methods and compositions that control lipid production.
  • Battrell, C Frederick; Gerdes, John; Mordue, Stephen; Capodanno, Jason; Hoekstra, Denise Maxine; Williford, John R; Clemmens, John, Methods and devices for microfluidic point-of-care immunoassays.
  • Harris, Timothy; Buzby, Philip Richard; Jarosz, Mirna; DiMeo, James Joseph; Gill, Jaime, Methods and devices for nucleic acid sequence determination.
  • Ovsyshcher, Eli; Fleidervish, Ilya A.; Goldberg, Yuri; Zeldets, Vladimir; Gelvan, Dan, Methods and implantable devices for treating supraventricular arrhythmias.
  • Quake, Stephen, Methods and kits for analyzing polynucleotide sequences.
  • Abbaszadegan Morteza ; Di Giovanni George Dominic ; LeChevallier Mark William, Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification.
  • Morteza Abbaszadegan ; George Dominic Di Giovanni ; Mark William LeChevallier, Methods and kits for detection of cryptosporidium parvum.
  • Idelevich, Pavel; Elkeles, Adi; Terkieltaub, Dov; Eyal, Ami; Gelvan, Dan Jacob, Methods and kits for differential staining of abnormal urinary system cells.
  • Kurn, Nurith, Methods and probes for detection and/or quantification of nucleic acid sequences.
  • Chan, Eugene Y., Methods and products for analyzing polymers.
  • Hanna, Michelle M.; McCarthy, David, Methods and reagents for detecting CpG methylation with a methyl CpG binding protein (MBP).
  • Yoshimura, Toru; Chiba, Ryotaro, Methods and reagents for diagnosing rheumatoid arthrtis.
  • Dube, Simant; Sun, Gang; Zhao, Lian-She, Methods and systems for determining a baseline during image processing.
  • Altschuler, Yoram; Tarcic, Gabi, Methods and systems for identifying patient specific driver mutations.
  • Dube, Simant; Sun, Gang; Zhao, Lian-She, Methods and systems for image processing of microfluidic devices.
  • Dube, Simant; Sun, Gang; Zhao, Lian-She, Methods and systems for image processing of microfluidic devices.
  • Dube, Simant; Sun, Gang; Zhao, Lian-She, Methods and systems for image processing of microfluidic devices.
  • Chaparian, Michael G.; Azad, Abul, Methods and targets of antibiotic resistance.
  • Lotan, Tamar; Eckhouse, Shimon, Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue.
  • Cech,Thomas R.; Lingner,Joachim; Nakamura,Toru; Chapman,Karen B.; Morin,Gregg B.; Harley,Calvin B.; Andrews,William H., Methods for detecting nucleic acids encoding human telomerase reverse transcriptase.
  • Hanna,Michelle M., Methods for determining nucleic acid methylation.
  • Nath, Avindra; Anderson, Caroline F; Irani, David; Cotter, Robert J; Steiner, Joseph P; Haughey, Norman, Methods for diagnosis and optimizing treatment of multiple sclerosis.
  • Scholl, David R.; Brown, James L.; Jollick, Jr., Joseph A.; Lollar, Ronald, Methods for direct fluorescent antibody virus detection in liquids.
  • Cheever Martin A. ; Disis Mary L., Methods for eliciting or enhancing reactivity to HER-2/neu protein.
  • Braun, Andreas; Koster, Hubert; Van den Boom, Dirk; Yip, Ping; Rodi, Charles; He, Liyan; Chiu, Norman; Jurinke, Christiane, Methods for generating databases and databases for identifying polymorphic genetic markers.
  • Braun, Andreas; Köster, Hubert; Van Den Boom, Dirk Johannes; Yip, Ping; Rodi, Charles; He, Liyan; Chiu, Norman; Jurinke, Christian, Methods for generating databases and databases for identifying polymorphic genetic markers.
  • Köster, Hubert; Braun, Andreas; Van Den Boom, Dirk; Ping, Yip; Rodi, Charlie; He, Liyan; Chiu, Norman; Jurinke, Christian, Methods for generating databases and databases for identifying polymorphic genetic markers.
  • Green, Jr., Richard E.; Lareau, Liana F., Methods for genome assembly and haplotype phasing.
  • Green, Jr., Richard E.; Lareau, Liana F., Methods for genome assembly and haplotype phasing.
  • Green, Jr., Richard E.; Lareau, Liana F., Methods for genome assembly and haplotype phasing.
  • Scholl, David R.; Brown, James L.; Jollick, Jr., Joseph A.; Lollar, Ronald, Methods for liquid direct fluorescent antibody intracellular virus detection.
  • Allman, Richard; Mantzaris, Debbie; Vom, Eduardo; Lewis, Craig Matthew, Methods for obtaining fetal genetic material.
  • Bouzek, Heather K., Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions.
  • Adli, Mazhar; Bernstein, Bradley E.; Mikkelsen, Tarjei S., Methods for preparing sequencing libraries.
  • Henderson Daniel R. (Benicia CA), Methods for protein binding enzyme complementation assays.
  • Staples Mark A. ; Haley Carolyn J. ; Parrish Richard F. ; Zmolek Wesley W., Methods for releasing a ligand from a complex.
  • Jen, Jin; Beaudry, Gary A.; Madden, Stephen L.; Bertlesen, Arthur H.; Sidransky, David, Methods for the diagnosis and treatment of lung cancer.
  • Jen, Jin; Beaudry, Gary A.; Madden, Stephen L.; Bertlesen, Arthur H.; Sidransky, David, Methods for the diagnosis and treatment of lung cancer.
  • Kurn, Nurith, Methods of RNA amplification in the presence of DNA.
  • Roiz, Levava; Schwartz, Betty; Smirnoff, Patricia; Shoseyov, Oded, Methods of and compositions for inhibiting the proliferation of mammalian cells.
  • Roiz, Levava; Schwartz, Betty; Smirnoff, Patricia; Shoseyov, Oded, Methods of and compositions for inhibiting the proliferation of mammalian cells.
  • Roiz, Levava; Schwartz, Betty; Smirnoff, Patricia; Shoseyov, Oded, Methods of and compositions for inhibiting the proliferation of mammalian cells.
  • Roiz, Levava; Schwartz, Betty; Smirnoff, Patricia; Shoseyov, Oded, Methods of and compositions for inhibiting the proliferation of mammalian cells.
  • Roiz,Levav; Schwartz,Betty; Smirnoff,Patricia; Shoseyov,Oded, Methods of and compositions for inhibiting the proliferation of mammalian cells.
  • Peled, Tony; Fibach, Eitan; Treves, Avi, Methods of controlling proliferation and differentiation of stem and progenitor cells.
  • Peled, Tony; Fibach, Eitan; Treves, Avi, Methods of controlling proliferation and differentiation of stem and progenitor cells.
  • Peled, Tony; Steinhardt, Yair, Methods of culturing and expanding mesenchymal stem cells.
  • Feinstein,Elena; Mor,Orna, Methods of diagnosing bladder cancer.
  • Coleman, Roger T.; Bandman, Olga; Wilde, Craig G., Methods of diagnosing pancreatic inflammation by using chemokine PANEC-1 antibodies.
  • Lockhart, David J.; Chee, Mark S.; Digglemann, Martin; Vetter, Dirk, Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA.
  • Peled, Tony; Treves, Avi; Rosen, Oren, Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby.
  • Mitrani, Eduardo N., Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs.
  • Dekker, Job; Lieberman, Erez; Van Berkum, Nynke; Gnirke, Andreas; Lander, Eric; Nusbaum, Chad; Williams, Louise; Melnikov, Alexandre; Giannoukos, Georgia, Methods of identifying interactions between genomic loci.
  • Peled, Tony, Methods of improving stem cell homing and engraftment.
  • Ronen, Gil; Golan, Ezekiel; Karchi, Hagai; Meissner, Rafael, Methods of increasing abiotic stress tolerance and/or biomass in plants.
  • Ronen, Gil; Golan, Ezekiel; Karchi, Hagai; Meissner, Rafael, Methods of increasing abiotic stress tolerance and/or biomass in plants.
  • Karchi, Hagai; Ronen, Gil; Yelin, Rodrigo; Rabinovich, Larisa, Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby.
  • Ronen, Gil; Golan, Ezekiel; Karchi, Hagai; Meissner, Rafael, Methods of increasing abiotic stress tolerance and/or biomass in plants generated thereby.
  • Ronen, Gil; Golan, Ezekiel; Karchi, Hagai; Meissner, Rafael, Methods of increasing abiotic stress tolerance, yield and/or biomass in plants.
  • Guegler, Karl J.; Hawkins, Phillip R.; Wilde, Craig G.; Seilhamer, Jeffrey J., Methods of screening for compounds that modulate the activity of ADEC, a chemokine expressed in inflamed adenoid.
  • Ashley, Euan A.; Perez, Marco V., Methods of treating heart failure with agonists of hypocretin receptor 2.
  • Coleman, Roger T.; Bandman, Olga; Wilde, Craig G., Methods of treating pancreatitis.
  • Guegler, Karl J.; Hawkins, Phillip R.; Wilde, Craig G.; Seilhamer, Jeffrey J., Methods of treatment with anitbodies to a chemokine expressed in inflamed adenoid.
  • Weiss, Shimon; Bruchez, Marcel; Alivisatos, Paul, Methods of use of semiconductor nanocrystal probes for treating a material.
  • Lotan, Tamar; Eckhouse, Shimon, Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent.
  • Kurn, Nurith, Methods, kits and compositions for single primer linear isothermal amplification of nucleic acid sequences.
  • Maor, Rudy, MicroRNA compositions and methods for enhancing plant resistance to abiotic stress.
  • Gunning, Kerry B.; Behlke, Mark Aaron, Microarray system with improved sequence specificity.
  • Gunning, Kerry B; Behlke, Mark Aaron, Microarray system with improved sequence specificity.
  • Clemmens, John; Battrell, C. Frederick; Gerdes, John; Hoekstra, Denise Maxine, Microfluidic mixing and analytical apparatus.
  • Battrell, C. Frederick; Clemmens, John; Sprague, Isaac, Microfluidic reactor system.
  • Parr, Ryan L.; Thayer, Robert; Dakubo, Gabriel; Creed, Jennifer; Robinson, Kerry; Maggrah, Andrea; Reguly, Brian; Harbottle, Andrew; Birch-Machin, Mark, Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers.
  • Parr, Ryan; Thayer, Robert; Dakubo, Gabriel; Maki, Jennifer; Robinson, Kerry; Maggrah, Andrea; Reguly, Brian; Harbottle, Andrew; Birch-Machin, Mark, Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers.
  • Gegg, Colin V.; Walker, Kenneth W.; Miranda, Leslie P.; Xiong, Fei, Modified Fc molecules.
  • Gegg, Colin V.; Walker, Kenneth W.; Miranda, Leslie P.; Xiong, Fei, Modified Fc molecules.
  • Gegg, Colin V.; Walker, Kenneth W.; Miranda, Leslie P.; Xiong, Fei, Modified Fc molecules.
  • Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  • Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  • Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  • Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  • Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  • Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  • Gegg,Colin; Xiong,Fei; Sitney,Karen C., Modified Fc molecules.
  • Park, Dongsu; Spencer, David; Lapteva, Natalia, Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods.
  • Dempcy, Robert O.; Afonina, Irina A.; Singer, Michael J.; Kutyavin, Igor V., Modified oligonucleotides for mismatch discrimination.
  • Dempcy,Robert O.; Gall,Alexander A.; Lokhov,Sergey G.; Afonina,Irina A.; Singer,Michael J.; Kutyavin,Igor V.; Vermeulen,Nicolaas M. J., Modified oligonucleotides for mismatch discrimination.
  • Paris, Daniel; Town, Terrence C.; Mullan, Michael J., Modulation of the phospholipase A2 pathway as a therapeutic.
  • Hanna, Michelle M.; McCarthy, David, Molecular beacon-based methods for detection of targets using abscription.
  • Bajic, Vladimir; Kaur, Mandeep, Molecular biomarker set for early detection of ovarian cancer.
  • Bajic, Vladimir; Kaur, Mandeep, Molecular biomarker set for early detection of ovarian cancer.
  • Hanna, Michelle M, Molecular detection systems utilizing reiterative oligonucleotide synthesis.
  • Hanna,Michelle M, Molecular detection systems utilizing reiterative oligonucleotide synthesis.
  • Hanna,Michelle M, Molecular detection systems utilizing reiterative oligonucleotide synthesis.
  • Hanna,Michelle M., Molecular detection systems utilizing reiterative oligonucleotide synthesis.
  • Boge, Annegret; Lavis, Luke D.; Sportsman, J. Richard; Hoekstra, Merl F.; Huang, Wei, Molecular modification assays.
  • Boge, Annegret; Sportsman, J. Richard; Gaudet, Elizabeth; Yi, George G., Molecular modification assays.
  • Huang,Wei; Hoekstra,Merl F.; Sportsman,J. Richard; Terpetschnig,Ewald A., Molecular modification assays.
  • Stein, Emily A.; Evans, Michael A., Molecular nets comprising capture agents and linking agents.
  • Morr챕,D. James; McCarty,NaMi; Morr챕,Dorothy; Chueh,Pin Ju, Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase.
  • Chang Chung Nan ; Landolfi Nicholas F. ; Martin Ulrich,DEX, Monoclonal antibodies specific for the platelet derived growth factor .beta. receptor and methods of use thereof.
  • Youn,Byung Soo; Yang,Young Soo; Lee,Nam Seok; Yu,Kang Yeol; Noh,Young Soon; Park,Hong Je; Youn,Moon Yeon; Chung,Min Sup; Min,Sung Shik; Jeong,Jae Jun, Monoclonal antibody selectively recognizing listeria monocytogenes, hybridoma producing the antibody, test kit comprising the antibody and detection method of listeria monocytogenes using the antibody.
  • Boes, Alexander; Spiegel, Holger; Edgue, Gueven; Beiss, Veronique; Sack, Markus; Reimann, Andreas; Fischer, Rainer, Multi-component-multistage malaria vaccines.
  • Lee,Jin Po, Multiple analyte assay device.
  • Ismagilov, Rustem F.; Shen, Feng; Kreutz, Jason E.; Du, Wenbin; Sun, Bing, Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes.
  • Ismagilov, Rustem F.; Shen, Feng; Kreutz, Jason E.; Du, Wenbin; Sun, Bing, Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes.
  • Ismagilov, Rustem F.; Shen, Feng; Kreutz, Jason E.; Du, Wenbin; Sun, Bing, Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes.
  • Chatterjee Malaya ; Kohler Heinz ; Chatterjee Sunil K. ; Foon Kenneth A., Murine anti-idiotype antibody 3H1.
  • Chatterjee, Malaya; Foon, Kenneth A.; Chatterjee, Sunil K., Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof.
  • Chatterjee,Malaya; Foon,Kenneth A.; Chatterjee,Sunil K., Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof.
  • Chatterjee,Malaya; Kohler,Heinz; Chatterjee,Sunil K.; Foon,Kenneth A., Murine monoclonal anti-idiotype antibody 3H1 sequences for human carcinoembryonic antigen.
  • Miasnikov, Andrei; Kumar, Vijay; Kensch, Oliver; Pellangahr, Klaus; Leuthner, Birgitta; Kettling, Ulrich; Koltermann, Andre, Mutant Citrobacter freundii phytase polypeptide.
  • Miasnikov, Andrei; Kumar, Vijay; Kensch, Oliver; Pellangahr, Klaus; Leuthner, Birgitta; Kettling, Ulrich; Koltermann, Andre, Mutant citrobacter freundii phytase polypeptide.
  • Shiloh Yosef,ILX, Mutated forms of the ataxia-telangiectasia gene and method to screen for a partial A-T phenotype.
  • Shiloh Yosef,ILX ; Tagle Danilo A. ; Collins Francis S., Mutated proteins associated with ataxia-telangiectasia.
  • Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity.
  • Gingeras,Thomas R.; Drenkow,Jorg, Mycobacterial rpoB sequences.
  • Charvat, Trevor T.; Hu, Cheng; Melikian, Anita; Novack, Aaron; Pennell, Andrew M. K.; Sullivan, Edward J.; Thomas, William D.; Ungashe, Solomon; Zhang, Penglie; Powers, Jay; Punna, Sreenivas, N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides.
  • Charvat, Trevor T.; Hu, Cheng; Melikian, Anita; Novack, Aaron; Pennell, Andrew M. K.; Sullivan, Edward J.; Thomas, William D.; Ungashe, Solomon; Zhang, Penglie; Powers, Jay; Punna, Sreenivas, N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl)hetaryl arylsulfonamides.
  • Charvat, Trevor T.; Hu, Cheng; Melikian, Anita; Novack, Aaron; Pennell, Andrew M. K.; Sullivan, Edward J.; Thomas, William D.; Ungashe, Solomon; Zhang, Penglie; Powers, Jay; Punna, Sreenivas, N-(2-(hetaryl)aryl)arylsulfonamides and N-(2-(hetaryl)hetaryl)arylsulfonamides.
  • Charvat, Trevor T.; Hu, Cheng; Melikian, Anita; Novack, Aaron; Pennell, Andrew M. K.; Sullivan, Edward J.; Thomas, William D.; Ungashe, Solomon; Zhang, Penglie; Powers, Jay; Punna, Sreenivas, N-(2-(hetaryl)aryl)arylsulfonamides and n-(2-(hetaryl)hetaryl) arylsulfonamides.
  • Jarvis, Gary A.; John, Constance M.; Leffler, Hakon, N-terminally truncated galectin-3 for use in treating cancer.
  • Golomb, Gershon; Sacks, Haigt; Najareh, Yousef; Fishbein, Elia; Chorny, Michael, Nanoparticles containing polymeric nucleic acid homologs.
  • Tainsky, Michael A.; Draghici, Sorin; Lin, Ho-Sheng, Neoepitope detection of disease using protein arrays.
  • Joseph Rajiv ; Dou Dexian, Neuronal-neonatal gene: neuronatin.
  • Lee, Daniel H. S.; Pepinsky, R. Blake; Li, Weiwei; Relton, Jane K.; Worley, Dane S.; Strittmatter, Stephen M.; Sah, Dinah W. Y.; Rabacchi, Sylvia A., Nogo receptor antagonists.
  • Lee, Daniel H. S.; Wen, Dingyi; Pepinsky, R. Blake; Relton, Jane K.; Wang, Xinzhong; Lugovskoy, Alexey; Meier, Werner; Garber, Ellen A.; Silvian, Laura; Weinreb, Paul H., Nogo receptor antagonists.
  • Lee,Daniel H. S.; Pepinsky,R. Blake; Li,Weiwei; Relton,Jane K.; Worley,Dane S.; Strittmatter,Stephen M.; Sah,Dinah W. Y.; Rabacchi,Sylvia A., Nogo receptor antagonists.
  • Lee, Daniel H. S.; Wen, Dingyi; Pepinsky, R. Blake; Relton, Jane K.; Wang, Xinzhong; Lugovskoy, Alexey; Meier, Werner; Garber, Ellen A.; Silvian, Laura; Weinreb, Paul H., Nogo receptor antagonists and methods of increasing neurite outgrowth.
  • Rouhani Riaz ; Sigler Gerald F., Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay.
  • Akhavan-Tafti, Hashem, Nonseparation assay methods.
  • Akhavan-Tafti, Hashem, Nonseparation assay methods.
  • Akhavan-Tafti, Hashem, Nonseparation assay methods.
  • Gohlke, James R.; Hedaya, Eddie; Kang, Jemo; Mier, Jeanette D., Novel chromogenic and/or fluorogenic substrates for monitoring catalytic or enzymatic activity.
  • Hochberg, Avraham; Matouk, Imad, Nucleic acid agents for downregulating H19 and methods of using same.
  • Hochberg, Avraham; Matouk, Imad, Nucleic acid agents for downregulating H19, and methods of using same.
  • Nazarenko Irina A. ; Bhatnagar Satish K. ; Winn-Deen Emily S. ; Hohman Robert J., Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon.
  • Nazarenko Irina A. ; Bhatnagar Satish K. ; Winn-Deen Emily S. ; Hohman Robert J., Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon.
  • Nazarenko Irina A. ; Bhatnagar Satish K. ; Winn-Deen Emily S. ; Hohman Robert J., Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon.
  • Kurn, Nurith; Wang, Shenglong, Nucleic acid amplification procedure using RNA and DNA composite primers.
  • Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Nucleic acid compositions for eliciting an immune response against telomerase reverse transcriptase.
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