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Crosslinked copolymers of ab 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08F-222/04
  • C08F-222/06
출원번호 US-0636569 (1975-12-01)
발명자 / 주소
  • Huper Fritz (Wuppertal DT) Rauenbusch Erich (Wuppertal DT) Schmidt-Kastner Gunter (Wuppertal DT) Bomer Bruno (Leverkusen DT) Bartl Herbert (Odenthal-Hahnenberg DT)
출원인 / 주소
  • Bayer Aktiengesellschaft (Leverkusen DT 03)
인용정보 피인용 횟수 : 41  인용 특허 : 0

초록 ▼

There are disclosed water-insoluble proteinic preparations in which a protein or polypeptide is bound to a copolymer, which preparations are useful for binding enzymes in order to carry out enzyme-catalyzable reactions. These preparations comprise a peptide material bound to a cross-linked copolymer

대표청구항

A crosslinked copolymer comprising the following copolymerized units: A. 2.0 to 20 weight percent of at least one ab4 to 9 carbon atoms; and B. 80 to 98 weight percent of at least one di- and/or poly(meth)acrylate of a diol and/or polyol.

이 특허를 인용한 특허 (41)

  1. Ekwuribe Nnochiri ; Ramaswamy Muthukumar ; Rajagopalan Jayanthi Sethuraman, Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same.
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  2. Sanders, John Larry; Mazo, Grigory; Mazo, Jacob, Anionic polymers composed of dicarboxylic acids and uses thereof.
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  3. Sanders, John Larry; Mazo, Grigory; Mazo, Jacob, Anionic polymers composed of dicarboxylic acids and uses thereof.
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  4. Ekwuribe, Nnochiri N.; Radhakrishnan, Balasingam, Calcitonin drug-oligomer conjugates, and uses thereof.
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  5. Ekwuribe, Nnochiri N.; Radhakrishnan, Balasingam, Calcitonin drug-oligomer conjugates, and uses thereof.
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  6. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Cation complexes of insulin compound conjugates, formulation and uses thereof.
    상세보기
  7. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Cation complexes of insulin compound conjugates, formulations and uses thereof.
    상세보기
  8. Ribba Alain (Crotelles FRX), Crosslinked carboxylic copolymers usable as thickeners in aqueous media and preparation thereof.
    상세보기
  9. Ekwuribe,Nnochiri N.; Ramaswamy,Muthukumar; Rajagopalan,Jayanthi, Drug-oligomer conjugates with polyethylene glycol components.
    상세보기
  10. Ekwuribe, Nnochiri N.; Rhadakrishnan, Balasingam; Price, Christopher H.; Anderson Jr., Wes; Ansari, Aslam M., Enkephalin conjugates.
    상세보기
  11. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Pavliv, Leo; Polowy, Karen; Puskas, Monica; Ekwuribe, Nnochiri N., Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof.
    상세보기
  12. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Pavliv, Leo; Polowy, Karen; Puskas, Monica; Ekwuribe, Nnochiri N., Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof.
    상세보기
  13. Ekwuribe Nnochiri Nkem ; Ramaswamy Muthukumar ; Radhakrishnan Balasingam ; Allaudeen HameedSulthan S., Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin.
    상세보기
  14. Ekwuribe,Nnochiri N.; Price,Christopher H.; Still,James Gordon; Filbey,Jennifer Ann; Ansari,Aslam M.; Odenbaugh,Amy L.; Radhakrishnan,Balasingam, Insulin conjugates for treating diabetes mellitus.
    상세보기
  15. Radhakrishnan,Balasingam; Soltero,Richard; Ekwuribe,Nnochiri N.; Puskas,Monica; Sangal,Diti, Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same.
    상세보기
  16. Soltero,Richard; Radhakrishnan,Balasingam; Ekwuribe,Nnochiri N., Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same.
    상세보기
  17. Ekwuribe,Nnochiri N.; Ramaswamy,Muthukumar; Rajagopalan,Jayanthi, Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin.
    상세보기
  18. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica E.; Ekwuribe, Nnochiri N., Insulin-oligomer conjugates, formulations and uses thereof.
    상세보기
  19. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Insulin-oligomer conjugates, formulations and uses thereof.
    상세보기
  20. Ekwuribe, Nnochiri N.; Rhadakrishnan, Balasingam; Price, Christopher H.; Anderson Jr., Wes; Ansari, Adam M., Methods for delivering therapeutics across blood-barrier and for altering receptor binding affinity.
    상세보기
  21. Ekwuribe, Nnochiri N.; Rhadakrishnan, Balasingam; Price, Christopher H.; Anderson, Jr., Wes; Ansari, Aslam M., Methods for delivery therapeutic compounds across the blood-brain barrier.
    상세보기
  22. Ekwuribe, Nnochiri N.; Radhakrishnan, Balasingam; Price, Christopher H.; Anderson, Jr., Wes; Ansari, Aslam M., Methods of activating a receptor using amphiphilic drug-oligomer conjugates.
    상세보기
  23. Still, James Gordon; Kosutic, Gordana, Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus.
    상세보기
  24. Soltero, Richard; Radhakrishnan, Balasingam; Ekwuribe, Nnochiri N., Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same.
    상세보기
  25. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties.
    상세보기
  26. Ekwuribe,Nnochiri N.; Price,Christopher H.; Still,James Gordon; Filbey,Jennifer Ann, Methods of treating diabetes mellitus.
    상세보기
  27. , Methods of treating diabetes mellitus.
    상세보기
  28. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  29. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Odenbaugh,Amy L., Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  30. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  31. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  32. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Radhakrishnan,Balasingam; Odenbaugh,Amy L., Mixtures of insulin drug-oligomer comprising polyalkylene glycol.
    상세보기
  33. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Radhakrishnan, Balasingam; Odenbaugh, Amy L., Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  34. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Radhakrishnan,Balasingam; Odenbaugh,Amy L., Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  35. James, Kenneth D.; Radhakrishnan, Balasingam; Malkar, Navdeep B.; Miller, Mark A.; Ekwuribe, Nnochiri N., Natriuretic compounds, conjugates, and uses thereof.
    상세보기
  36. Khedkar, Anand; Rangappa, Sharath Kumar Mallapura; Subramani, Ramesh; Dave, Nitesh; Radhakrishnan, Devesh; Shankar, Sundaresh; Chivukula, Sudheer; Ramakrishna, Ranjith; Murthy, Shanmugam Thandava; Pai, Harish Venkatraman; Sengupta, Nilanjan; Melarkode, Ramakrishnan; Iyer, Harish, Orally administrable solid pharmaceutical composition and a process thereof.
    상세보기
  37. Soltero, Richard; Radhakrishan, Balasingam; Ekwuribe, Nnochiri N.; Rehlaender, Bruce; Hickey, Anthony; Bovet, Li Li, Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith.
    상세보기
  38. Soltero,Richard; Radhakrishan,Balasingam; Ekwuribe,Nnochiri N.; Rehlaender,Bruce; Hickey,Anthony; Bovet,Li Li, Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith.
    상세보기
  39. Keller Reinhold (Bad Soden am Taunus DEX) Schlingmann Merten (Knigstein DEX), Process for the preparation of 5′-ribonucleotides.
    상세보기
  40. Radhakrishnan, Balasingam; Soltero, Richard; Ekwuribe, Nnochiri N., Proinsulin polypeptide-oligomer conjugates.
    상세보기
  41. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Odenbaugh,Amy L., Substantially monodispersed mixtures of polymers having polyethylene glycol moieties.
    상세보기

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