초록 ▼

It has been found that the shelf life of stored whole blood may be doubled by adding a buffer which maintains a desired pH level. However, this buffer causes the generation of CO2 which, if not removed at a controlled rate, causes the pH value of the blood to decrease, which shortens the useful life

It has been found that the shelf life of stored whole blood may be doubled by adding a buffer which maintains a desired pH level. However, this buffer causes the generation of CO2 which, if not removed at a controlled rate, causes the pH value of the blood to decrease, which shortens the useful life of the blood. This invention provides a blood storage bag which permits the CO2 to be diffused out at a controlled rate into the atmosphere, thereby maintaining the desired pH value while providing a bag strong enough to permit handling thereof.

대표청구항 ▼

A method of storing blood which has been treated with a selected compound to extend the useful life of the blood, said treatment resulting in the subsequent production of CO2, the method comprising the steps of: providing a closeable plastic bag adapted to contain a preselected quantity of treated b

A method of storing blood which has been treated with a selected compound to extend the useful life of the blood, said treatment resulting in the subsequent production of CO2, the method comprising the steps of: providing a closeable plastic bag adapted to contain a preselected quantity of treated blood, the bag having first wall portions of a thickness chosen to enable CO2 to diffuse through said portions at a selected predetermined rate so as to maintain the pH of said treated blood within a selected range, said bag having second wall portions for providing strength for said bag to withstand pressure applied thereto at least by the stored blood; and storing the treated blood in said baG. A system for the storage of a liquid within a closed bag wherein a predetermined gas is formed, and for controlling a selected characteristic of said liquid, which is related to the content of said gas in said bag, said system comprising: a bag having semi-permeable wall means including thin wall means of preselected thickness for enabling said gas to diffuse through said thin wall means at a selected rate, to thereby control the selected characteristic of said liquid, said wall means including reinforcing means for enabling said bag to withstand pressure, wherein said reinforcing means comprises a spaced ribbing of the same material as the material of said thin wall means and which is integral therewith and of a thickness sufficient to reinforce said bag and the ratio of the surface area of said thin wall means to the total surface area of said bag is preselected to control the characteristic of said liquid by controlling the rate of diffusion of said gas through said thin wall means. A system for storing whole blood or red blood cells which has been treated to extend its usable life, which treatment results in the production of CO2 and requires the removal of CO2 at a predetermined rate, so as to maintain the pH of the blood or the red blood cells within a selected range, said system comprising: a bag having semi-permeable wall means including thin wall means of preselected thickness for enabling CO2 to diffuse through said wall means at a selected rate, said wall means including reinforcing means juxtaposed with said thin wall means for enabling said bag to withstand pressure, the ratio of the surface area of said thin wall means, which do not include said reinforcing means, to the total surface area of said wall means being selected to control the rate of diffusion of the CO2 through said thin wall means so that the pH of the blood or the red blood cells in said bag is maintained within said selected range.