초록 ▼

Pharmaceutical composition unit dosage forms adapted for enteral or topical administration are described, comprising a safe and effective amount of a pharmaceutically active medicament compound dissolved or uniformly dispersed in a flexible, water-soluble film carrier therefor. Admixtures of medicam

Pharmaceutical composition unit dosage forms adapted for enteral or topical administration are described, comprising a safe and effective amount of a pharmaceutically active medicament compound dissolved or uniformly dispersed in a flexible, water-soluble film carrier therefor. Admixtures of medicament and carrier are drawn into a film, which can be cut to desired unit dosage content.

대표청구항 ▼

A process for the preparation of a pharmaceutical composition in unit dosage form adapted for enteral or topical administration and comprising a safe and effective amount of a pharmaceutically active medicament compound uniformly dispersed throughout a flexible, water-soluble film carrier therefor,

A process for the preparation of a pharmaceutical composition in unit dosage form adapted for enteral or topical administration and comprising a safe and effective amount of a pharmaceutically active medicament compound uniformly dispersed throughout a flexible, water-soluble film carrier therefor, which comprises the steps of: (a) drawing into a sheet having a uniform layer thickness of about 0.1-2 mm and a dry thickness of about 0.05-1 mm., a homogeneous solution or suspension consisting essentially of (1) up to 60% by weight, based on the film carrier, of the medicament, (2) 0-30% by weight of a pharmaceutically acceptable filler, (3) a film-forming amount of a water-soluble film-forming polymer, and (4) as solvent or suspending medium, one or both of water and an organic volatile solvent system comprising an organic polar solvent miscible in water; and (b) drying the thus-formed sheet to remove the solvent or suspending medium therefrom.