초록 ▼

Delivery systems manufactured in the form of polymeric compositions for the controlled delivery of macromolecules to environments of use are disclosed. The systems are characterized as two-phase compositions comprising a phase formed of an insoluble polymeric matrix having limited water sorptivity c

Delivery systems manufactured in the form of polymeric compositions for the controlled delivery of macromolecules to environments of use are disclosed. The systems are characterized as two-phase compositions comprising a phase formed of an insoluble polymeric matrix having limited water sorptivity containing in admixture therein an interpenetrating phase formed of a particulate hydrophilic water swellable, biologically active macromolecular material.

대표청구항 ▼

A therapeutic system for the continuous and controlled administration of insulin, said system being in the form of a body which is sized and shaped for placement in the environment of use, comprising a two-phase composition of: (a) a first phase comprising a biocompatible, plastically deformable, hy

A therapeutic system for the continuous and controlled administration of insulin, said system being in the form of a body which is sized and shaped for placement in the environment of use, comprising a two-phase composition of: (a) a first phase comprising a biocompatible, plastically deformable, hydrophobic matrix having an aqueous fluid sorptivity not greater than 50% by weight, of ethylene-vinyl ester copolymer of the general formula: [Figure] wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 7 carbons and phenyl, the polymer being insoluble in the environment of use, substantially impermeable to diffusion therethrough of insulin, and containing in admixture therewith; (b) a second phase comprising from about 3 to 90 parts by weight of agglomerated particles of insulin.