초록 ▼

A process and apparatus are provided for continuously separating blood into plasma and cellular component fractions and returning the latter to the subject in admixture with a makeup fluid. The separation is effected by continuously ultrafiltering the subject\s blood at specified shear stresses and

A process and apparatus are provided for continuously separating blood into plasma and cellular component fractions and returning the latter to the subject in admixture with a makeup fluid. The separation is effected by continuously ultrafiltering the subject\s blood at specified shear stresses and pressures employing a membrane ultrafilter, preferably having a pore size of 0.45 microns, and a disclosed flow system.

대표청구항 ▼

A continuous plasmapheresis process comprising: (a) continuously withdrawing whole blood from the blood vessel of a donor and pumping said whole blood into the filtering chamber of an ultrafiltration cell; (b) continuously filtering said whole blood into a cellular component fraction and a plasma fr

A continuous plasmapheresis process comprising: (a) continuously withdrawing whole blood from the blood vessel of a donor and pumping said whole blood into the filtering chamber of an ultrafiltration cell; (b) continuously filtering said whole blood into a cellular component fraction and a plasma fraction by passing it in a flow over and parallel to an ultrafilter membrane having a pore size of from about 0.1 to 1.0 microns in diameter, and at a flow rate sufficient to provide a shear stress at the membrane interface of from about 10 dynes/cm2 to about 1000 dynes/cm2 at transmembrane pressures of from about 50 mm of mercury to about 700 mm of mercury; (c) continuously admixing said cellular component fraction with an amount of replacement fluid substantially equal to said separated plasma fraction; and (d) continuously returning said cellular component fraction and replacement fluid mixture to a blood vessel of said donor.