초록 ▼

An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned

An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned distant from the first wall, said second wall a microporous or hydrogel material that extends around the first wall, and (3) a distribution zone interposed between the first and second wall and initially housing a compound soluble in an external fluid that enters the system. In operation, agent is dispensed from the system by fluid passing through the second wall into the zone from which fluid is further being imbibed through the first wall into the compartment forming a solution that is released through the passageway into the zone, and then through the second wall to the exterior of the system.

대표청구항 ▼

A laminate useful for manufacturing a device for dispensing a beneficial agent to a fluid environment of use, said laminate comprising a first lamina formed of a member selected from the group consisting of cellulose acylate, cellulose diacylate and cellulose triacylate, a third lamina spaced distan

A laminate useful for manufacturing a device for dispensing a beneficial agent to a fluid environment of use, said laminate comprising a first lamina formed of a member selected from the group consisting of cellulose acylate, cellulose diacylate and cellulose triacylate, a third lamina spaced distant from the first lamina, said third lamina formed of a composition comprising a polymer and a pore-former selected from the group consisting of carbohydrates and salts dispersed in the polymer, which polymer is a member selected from the group consisting of cellulose acylate, cellulose discylate and cellulose triacylate, and a second lamina positioned between the first and third lamina which second lamina is formed of a member selected from the group consisting of essentially salt and carbohydrate soluble in the fluid present in the environment of use. An osmotic system for dispensing a beneficial agent to an environment of use, said system comprising: (a) a first wall formed a semipermeable material permeable to the passage of fluid present in the environment of use and substantially impermeable to the passage of beneficial agent; a second wall formed of a polymer that maintains its physical and chemical integrity during the dispensing period and contains a pore forming agent dispersed therein, said second wall spaced distant and around the first wall; and, a layer formed of a compound soluble in fluid that enters the compartment positioned between the first and second walls; said walls surrounding with the first wall facing; (b) a compartment; (c) a beneficial agent housed in the compartment; and, (d) a passageway in the first wall communicating the compartment with the layer.