초록 ▼

A polymer suitable for use in affinity chromatography comprising a polymer of an aminimide and a vinyl compound having at least one pendant halo-methyl group and the said polymer wherein an amine ligand which affords sites for binding in affinity chromatography is coupled to the polymer by reaction

A polymer suitable for use in affinity chromatography comprising a polymer of an aminimide and a vinyl compound having at least one pendant halo-methyl group and the said polymer wherein an amine ligand which affords sites for binding in affinity chromatography is coupled to the polymer by reaction with a portion of the pendant halo-methyl groups and the remainder of said pendant halo-methyl groups are reacted with an amine containing a pendant hydrophilic group. The invention also comprises a method of coating a substrate with the above polymer and a method of fractionating mixtures by affinity chromatography employing the above polymer as an adsorbent.

대표청구항 ▼

A method of coating a support with an addition copolymer of (1) at least one aminimide of the formula: [Figure] wherein R1 and R2 are the same or different and represent lower alkyl; R3 represents an organic group; and Z represents the residue of a polymerizable vinyl compound, and (2) a vinyl compo

A method of coating a support with an addition copolymer of (1) at least one aminimide of the formula: [Figure] wherein R1 and R2 are the same or different and represent lower alkyl; R3 represents an organic group; and Z represents the residue of a polymerizable vinyl compound, and (2) a vinyl compound having at least one pendant primary halomethyl group, said polymer having coupled thereto by reaction with a portion of the pendant primary halomethyl groups an amine ligand which affords sites for binding in affinity chromatography, comprising contacting a support with a solvent solution of the polymer, removing said solvent and contacting said coated support with a non-solvent for the final polymer containing a primary amine having a pendant hydrophilic group, whereby said amine reacts with the remainder of said primary halomethyl groups and enhances the bond between said polymer and said support.