초록 ▼

Polymers of quaternary-structured collagen of minimum length, diameter and periodicity, and containing a relatively high positive electrostatic charge are claimed as hemostatic agents. Specific examples are guanidnated polymers of the type described, esterified polymers, and esterified-guanidinated

Polymers of quaternary-structured collagen of minimum length, diameter and periodicity, and containing a relatively high positive electrostatic charge are claimed as hemostatic agents. Specific examples are guanidnated polymers of the type described, esterified polymers, and esterified-guanidinated polymers.

대표청구항 ▼

An improved collagen hemostatic agent comprising enzyme-solubilized telopeptide-poor, crosslinked, polymeric collagen of regularly staggered quaternary structure having a minimum molecular length of 7000 A°, a minimum molecular diameter of 20 A°, a minimum periodicity of 670-700 A°and whose residual

An improved collagen hemostatic agent comprising enzyme-solubilized telopeptide-poor, crosslinked, polymeric collagen of regularly staggered quaternary structure having a minimum molecular length of 7000 A°, a minimum molecular diameter of 20 A°, a minimum periodicity of 670-700 A°and whose residual lysyl and carboxyl groups have been subjected respectively to at least one reaction selected from the group consisting of guanidination, esterification and guanidination-esterification to greatly enhance the net positive electrostatic charge of the collagen polymer.