초록

The rate of release of medicament from a controlled release tablet having a polymeric vinylpyrrolidonecarboxyvinyl hydrophilic core is improved by coating the medicament-containing core with a substantially insoluble rupturable film which is water permeable.

대표청구항 ▼

A film coated controlled release medicinal tablet comprising: (i) a compressed matrix comprising an effective amount of medicament dispersed in a blend of 1:10 to 10:1 parts by weight polymeric vinyl pyrrolidone and a carboxyvinyl hydrophilic polymer; and (ii) a substantially water insoluble, water

A film coated controlled release medicinal tablet comprising: (i) a compressed matrix comprising an effective amount of medicament dispersed in a blend of 1:10 to 10:1 parts by weight polymeric vinyl pyrrolidone and a carboxyvinyl hydrophilic polymer; and (ii) a substantially water insoluble, water permeable film coating on the compressed matrix, the film coating having a thickness of about 1 to 15 mil. and comprising a blend of hydrophobic polymer selected from the group consisting of cellulose ethyl esters, cellulose acetate, polyvinyl alcohol-maleic anhydride copolymers, b4:1 to about 1:4; wherein the release rate of medicament is initially controlled primarily by the film coating and after rupture or erosion of the film the release rate of medicament is controlled by the compressed matrix; and wherein the release of the medicament through the film begins within about one hour after the tablet has been ingested.