초록 ▼

A dispenser is disclosed for dispensing a beneficial agent to a fluid environment. The dispenser comprises an impermeable container, a reservoir, a passageway, a beneficial agent, and a polymeric agent. In operation, beneficial agent is dispensed by fluid entering the reservoir motivating the polyme

A dispenser is disclosed for dispensing a beneficial agent to a fluid environment. The dispenser comprises an impermeable container, a reservoir, a passageway, a beneficial agent, and a polymeric agent. In operation, beneficial agent is dispensed by fluid entering the reservoir motivating the polymeric agent to undergo fluid induced transition to a viscofluid, with beneficial agent dispensed by (a) viscofluid exiting through the passageway and transporting beneficial agent concurrently therewith, or by (b) beneficial agent exhibiting an increased coefficient of diffusion in the viscofluid and diffusing therethrough to the exterior of the device. An embodiment of the invention pertaining to laminates also is disclosed as useful for manufacturing the dispenser.

대표청구항 ▼

A dispenser for the controlled dispensing of a beneficial agent to a fluid environment of use, the dispenser comprising: (a) a container having a wall impermeable to fluid and impermeable to agent, said wall surrounding an internal reservoir having an uniform measurement along a given dimension; (b)

A dispenser for the controlled dispensing of a beneficial agent to a fluid environment of use, the dispenser comprising: (a) a container having a wall impermeable to fluid and impermeable to agent, said wall surrounding an internal reservoir having an uniform measurement along a given dimension; (b) a passageway in the container connecting the reservoir with the exterior of the dispenser, said passageway having an area that permits entry of fluid into the reservoir, and release of beneficial agent from the reservoir; (c) means in the reservoir for dispensing the beneficial agent from the dispenser, said means (1) occupying a volume having a constant cross-sectional area parallel to the passageway and housing the beneficial agent therein, (2) absorbs fluid that enters the reservoir and undergoes fluid induced relaxation from an unrelaxed to a relaxed state, with (3) the beneficial agent exhibiting an increased coefficient of diffusion in the relaxed means; and, (d) wherein, when the dispenser is in operation in the fluid environment of use, beneficial agent is dispensed by diffusion through the relaxed means and the passageway at a controlled rate from the dispenser in an amount that corresponds to the amount of agent within the means that goes from an unrelaxed to a relaxed state, which relaxation occurs at a rate governed by the progressive fluid absorption and accompanying induced relaxation of the means over time.