초록

Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surround the seal coated core are disclosed.

대표청구항 ▼

A sustained release pharmaceutical composition comprising a compressed core, a seal coating surrounding the core and a sugar coating surrounding the seal coated core wherein, (a) the core comprises a drug in an amount of about 20% to about 70% by weight of the core, at least one pharmaceutically acc

A sustained release pharmaceutical composition comprising a compressed core, a seal coating surrounding the core and a sugar coating surrounding the seal coated core wherein, (a) the core comprises a drug in an amount of about 20% to about 70% by weight of the core, at least one pharmaceutically acceptable water soluble polymer selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropyl cellulose, xanthan gum and karaya gum, and at least one pharmaceutically acceptable water insoluble polymer mixture selected from the group consisting of ethylcellulose and ethyl cellulose and at least one of carboxypolymethylene, hydroxypropyl methylcellulose phthalate and hydroxypropylcellulose, said polymers in an amount of about 30% to about 72% by weight of the core; (b) the seal coating comprises a film coating material selected from the group consisting of enteric and non-enteric materials and mixtures thereof; and (c) the sugar coating comprises sugar and a loading dose of said drug contained in the core; with the proviso that when the water soluble polymer is only hydroxypropyl methylcellulose then the water insoluble polymer is not only ethylcellulose, and that when the water insoluble polymer is only ethylcellulose than the water soluble polymer is not only hydroxypropyl methylcellulose; and with the further proviso that when the seal coating consists essentially of an enteric coating material the drug is other than propranolol or its pharmaceutically acceptable salts.