초록 ▼

Novel compounds are produced by the fermentation of a nutrient medium with the previously undescribed microorganism Streptomyces avermitilis. They may be isolated by solvent extraction and chromatographic fractionation techniques. The compounds, which are described generically as C-076 have signific

Novel compounds are produced by the fermentation of a nutrient medium with the previously undescribed microorganism Streptomyces avermitilis. They may be isolated by solvent extraction and chromatographic fractionation techniques. The compounds, which are described generically as C-076 have significant parasiticidal activity. The compounds may be included in compositions for the oral or parenteral administration to animals for the treatment of parasitic infections.

대표청구항 ▼

A compound having the formula: [Figure] wherein R is: [Figure] and wherein the broken line indicates a single or a double bond; R1 is hydroxy and is present only when said broken line indicates a single bond; R2 is iso-propyl or sec-butyl; and R3 is methoxy or hydroxy. A composition useful for the t

A compound having the formula: [Figure] wherein R is: [Figure] and wherein the broken line indicates a single or a double bond; R1 is hydroxy and is present only when said broken line indicates a single bond; R2 is iso-propyl or sec-butyl; and R3 is methoxy or hydroxy. A composition useful for the treatment of parasitic diseases which comprises an inert carrier having a pharmaceutically effective amount of one or more of the compounds of claim 1 incorporated therein.