초록

Biodegradable particles, with a diameter smaller than 500 nanometers, formed by the micellar polymerization of an alkyl-cyano-acrylate where the term “alkyl”means a lower alkyl radical having 1 to 4 carbon atoms and containing a biologically active substance.

대표청구항 ▼

Biodegradable particles having a diameter less than 500 nanometers for oral or parenteral administration in a human or animal host, said particles comprising a substantially spherical, dense, filamentous, polymeric network, wherein the polymeric network has dispersed therethrough a biologically acti

Biodegradable particles having a diameter less than 500 nanometers for oral or parenteral administration in a human or animal host, said particles comprising a substantially spherical, dense, filamentous, polymeric network, wherein the polymeric network has dispersed therethrough a biologically active substance, and wherein said polymer is biodegradable in said host and is formed by the micellar polymerization of an alkyl cyano-acrylate said alkyl group containing 1 to 4 carbon atoms, and when said polymer particles are biodegraded in said host, the biologically active substance is progressively released into said host at a rate substantially corresponding to the rate of biodegradation of said polymer. Biodegradable particles having a diameter less than 500 nanometers for use as a diagnostic agent, said particles comprising a substantially spherical, dense, filamentous, polymeric network wherein the polymeric network has dispersed therethrough a biologically active substance, and wherein said polymer is biodegradable and is formed by the micellar polymerization of an alkyl cyano-acrylate in an aqueous solution of a surface active agent and at a pH less than 7, said alkyl containing 1 to 4 carbon atoms, and wherein said polymer particles are biodegraded in use as a diagnostic agent whereby the biologically active substance is progressively released at a rate substantially corresponding to the rate of biodegradation of said polymer.