초록 ▼

An aseptically pure dispensing anticoagulant device adapted to be connected to a blood collection set and which may be aseptically treated by ethylene oxide or other high diffusivity sterilant without deleterious effects upon the anticoagulant. Various embodiments are shown; in one, a collapsible po

An aseptically pure dispensing anticoagulant device adapted to be connected to a blood collection set and which may be aseptically treated by ethylene oxide or other high diffusivity sterilant without deleterious effects upon the anticoagulant. Various embodiments are shown; in one, a collapsible pouch is provided which includes a barrier against diffusion of water vapor and ethylene oxide. In another embodiment, a rigid anticoagulant container is employed which necessitates a secondary volume of air in a surrounding pouch to provide air to displace liquid in the rigid container as it passes into the set.

대표청구항 ▼

1. A blood collection set, comprising: a. an anticoagulant solution in a first rigid container impermeable to water vapor and sterilant; b. a blood receiving container; c. a second container, permeable to said sterilant, surrounding said first container; d. conduit means interconnecting said s

1. A blood collection set, comprising: a. an anticoagulant solution in a first rigid container impermeable to water vapor and sterilant; b. a blood receiving container; c. a second container, permeable to said sterilant, surrounding said first container; d. conduit means interconnecting said second container and said bag; and e. rupture means for rupturing the first container so that the anticoagulant solution may flow from said first container through the conduit means connecting the second container and said bag. 2. The apparatus of claim 1 in which a volume of air is provided between the first container and the second container, said volume of air being sufficiently large so as to displace the fluid anticoagulant solution in the first container. 3. The apparatus of claim 1 in which the rupture means comprises a rigid guide means secured to one end of said first rigid container and having a spike means slidably disposed within said rigid guide means. 4. The apparatus of claim 3 in which the rigid spike has a pair of passageways, one of which, when the spike has punctured the first rigid container, provides a passage for the flow of anticoagulant from the container to the conduit means, the other of which provides an air passage between the end of the spike nearest the first rigid container and a volume of air intermediate said first and second containers. 5. The apparatus of claim 4 having closure means for maintaining the anticoagulant passageway closed until the spike punctures the first rigid container. 6. The apparatus of claim 5 in which the closure means includes a sleeve provided coaxial to said spike and intermediate said guide means. 7. The apparatus of claim 6 in which the sleeve is adapted to expand within said guide means as said spike is slid toward said first rigid container in the act of puncturing the container. 8. The apparatus of claim 7 in whicn the sleeve abuts a puncturable portion of said rigid container. 9. A method of sterilizing the equipment necessary for drawing blood and mixing the blood with an anticoagulant comprising the steps of: (a) sterilizing an integral anticoagulant container of material impermeable to high diffusivity sterilant by a high temperature steam autoclave process; (b) connecting puncture means between said anticoagulant container and a second container; (c) encapsulating said integral anticoagulant container and puncture means within said second container comprising flexible, compressable, material; (d) connecting conduit means from a phlebotomy needle to said second container; and (e) connecting conduit means from said phlebotomy needle to a whole blood collecting bag. 10. The method of claim 9 including the additional step of: sterilizing the interior of the equipment with high diffusivity sterilant after the sterilized anticoagulant container has been encapsulated in the second container. 11. A blood collection set, comprising: a. an anticoagulant solution in a first container impermeable to water vapor and sterilant, said first container comprising a foil lined plastic pouch; b. a blood receiving container; c. a second plastic bag container, permeable to said sterilant, surrounding said first container; d. conduit means interconnecting said second container and said blood receiving container, and e. rupture means intermediate said first container and said conduit means to rupture the first container so that the anticoagulant solution may flow from said first container to the conduit means connecting the second container and said blood receiving container.