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특허 상세정보

Bone graft material for osseous defects and method of making same

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-009/00    A61K-035/32   
미국특허분류(USC) 424/15 ; 106/161 ; 106/122 ; 260/1237
출원번호 US-0304367 (1981-09-21)
발명자 / 주소
인용정보 피인용 횟수 : 394  인용 특허 : 4
초록

Complexes of reconstituted collagen and demineralized bone particles or reconstituted collagen and a solubilized bone morphogenetic protein fabricated in a sponge suitable for in vivo implantation in osseous defects are disclosed. Both demineralized bone particles (DBP) and bone morphogenetic protein have demonstrated the ability to induce the formation of osseous tissue in animal and human experiments. Reconstituted collagen conjugate is highly biocapatible and can be fabricated in a variety of configurations, especially as a sponge. This material can b...

대표
청구항

A bone graft material capable of inducing the formation of osseous tissue in the animal in which it is implanted, said bone graft material consisting essentially of a collagen conjugate containing: from about 65 to about 95 weight percent reconstituted collagen having dispersed substantially uniformly therein from about 35 to about 5 weight percent of (a) demineralized bone particles, (b) solubilized bone morphogenic protein, or (c) mixtures of demineralized bone particles and solubilized bone morphogenic protein, said bone graft material adapted to indu...

이 특허를 인용한 특허 피인용횟수: 394

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