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Phosphoramidite compounds and processes 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-017/00
출원번호 US-0248450 (1981-03-27)
발명자 / 주소
  • Caruthers Marvin H. (Boulder CO) Beaucage Serge L. (Boulder CO)
출원인 / 주소
  • University Patents, Inc. (Norwalk CT 02)
인용정보 피인용 횟수 : 447  인용 특허 : 0

초록

A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.

대표청구항 ▼

A compound represented by one of the formulae: [Figure] wherein B is a nucleoside or deoxynucleoside base; A is H, OH or OR2 in which R2 is a blocking group; R is a blocking group; R1 is a hydrocarbyl radical containing up to about 10 carbon atoms; and X is NR2R3, wherein R2 and R3 taken separately

이 특허를 인용한 특허 (447)

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  315. Caruthers Marvin H. (Boulder CO) Brill Wolfgang K. D. (Schopfheim DEX) Yau Eric (Mercer Island WA) Ma Michael (New York NY) Nielsen John (Horsholm DKX), Nucleoside thiophosphoramidites.
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  330. Woolf, Tod; Taylor, Margaret, Oligonucleotide compositions with enhanced efficiency.
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  336. Crooke, Stanley T., Oligoribonucleotides and ribonucleases for cleaving RNA.
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  337. Scaringe Stephen A., Orthoester protecting groups.
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  341. Tsukada, Mamoru, PCR amplification reaction apparatus and method for PCR amplification reaction using apparatus.
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  348. Guzaev, Andrei Pavel; Vvedenskiy, Vladimir Y., Phosphoramidite building blocks for sugar-conjugated oligonucleotides.
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  349. Nojiri Ryuji (Aichi JPX) Hayakawa Yoshihiro (Ichinomiya JPX) Uchiyama Mamoru (Kawasaki JPX) Kato Hisatoyo (Ohbu JPX) Chino Yasuyoshi (Tokyo JPX) Tahara Shinichiro (Yokohama JPX), Phosphoramidite compounds and process for production thereof.
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  354. Bhat, Balkrishen; Swayze, Eric E.; Prakash, Thazha P.; Allerson, Charles; Dande, Prasad; Griffey, Richard H., Positionally modified siRNA constructs.
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  355. Just George,CAX ; Xin Zhili ; Marsault Eric,CAX ; Jin Yi,CAX ; Wang Jianchao,CAX ; Manoharan Muthiah, Preparation of phosphorothioate and boranophosphate oligomers.
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  356. George Just CA; Zhili Xin ; Eric Marsault CA; Yi Jin CA; Jianchao Wang CA, Preparation of phosphorothioate oligomers.
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  378. Ravikumar Vasulinga T., Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds.
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  380. Klem Robert E. ; Marvin William B. ; Riley Timothy A., Process for the synthesis of oligonucleotides and analogs with low water oxidation step.
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  381. Ross,Bruce; Song,Quanlai, Process of purifying phosphoramidites.
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  382. Reddy M. Parameswara (Brea CA) Farooqui Firdous (La Habra CA), Processes for synthesizing nucleotides and modified nucleotides using N4 protected deoxycytidines.
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  386. Cheruvallath Zacharia S. ; Capaldi Daniel C. ; Ravikumar Vasulinga T. ; Cole Douglas L., Protecting group for synthesizing oligonucleotide analogs.
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  387. Cheruvallath Zacharia S. ; Capaldi Daniel C. ; Ravikumar Vasulinga T. ; Cole Douglas L., Protecting group for synthesizing oligonucleotide analogs.
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  388. Cheruvallath Zacharia S. ; Capaldi Daniel C. ; Ravikumar Vasulinga T. ; Cole Douglas L., Protecting group for synthesizing oligonucleotide analogs.
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  390. Kirschenheuter Gary P. ; Eaton Bruce, Pyrimidine nucleosides as therapeutic and diagnostic agents.
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  391. Woolf, Tod M.; Kamens, Joanne; Salomon, William; Khvorova, Anastasia, RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality.
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  392. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Pavco, Pamela A.; Libertine, Lyn; Cardia, James; Bulock, Karen G., RNA interference in dermal and fibrotic indications.
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  396. Cheruvallath Zacharia S. ; Ravikumar Vasulinga T. ; Cole Douglas L. ; Capaldi Daniel C., Reagent useful for synthesizing sulfurized oligonucleotide analogs.
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  397. Cheruvallath Zacharia S. ; Ravikumar Vasulinga T. ; Cole Douglas L. ; Capaldi Daniel C., Reagent useful for synthesizing sulfurized oligonucleotide analogs.
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  398. Zacharia S. Cheruvallath ; Vasulinga T. Ravikumar ; Douglas L. Cole ; Daniel C. Capaldi, Reagent useful for synthesizing sulfurized oligonucleotide analogs.
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  399. Prudent, James R.; Sherrill, Christopher B., Reagents for the improved synthesis of isoguanosine containing oligonucleotides.
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  400. Sanghvi Yogesh S. ; Guo Zhiqiang, Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis.
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  407. Livingston Douglas Alan, Selective capping solution phase oligonucleotide synthesis.
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  414. Prakash, Thazha P.; Swayze, Eric E., Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom.
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  416. Barany George ; Hammer Robert P. ; Musier-Forsyth Karin ; Xu Qinghong ; Chen Lin, Sulfurization of phosphorus-containing compounds.
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  428. Prakash, Thazha P.; Swayze, Eric E., Tetrahydropyran nucleic acid analogs.
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  433. Linton, John; Katz, Arrin; Brenan, Colin; Yoder, Karl; Hess, Robert; Madrone, Leila; Ellis, Robert; Kanigan, Tanya; Friesen, Kristine; Morrison, Thomas; Garcia, Javier, Thermal cycling apparatus and method.
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