초록 ▼

What are disclosed are methods for making a suspension suitable for use as a coating agent for medicaments by suspending a powder of certain vinyl copolymers in an aqueous solution or suspension of a plasticizer therefor, methods for converting such a suspension of copolymer in plasticizer into a fi

What are disclosed are methods for making a suspension suitable for use as a coating agent for medicaments by suspending a powder of certain vinyl copolymers in an aqueous solution or suspension of a plasticizer therefor, methods for converting such a suspension of copolymer in plasticizer into a film-forming solution or other extensively homogeneous phase, such suspensions and the film-forming conversion products thereof, and methods for coating medicaments with such suspensions and film-forming conversion products.

대표청구항 ▼

The method for making an aqueous suspension of a synthetic resin copolymer, which suspension is adaptable to use for forming a coating on a medicament core to form an orally-ingestible pharmaceutical dosage unit form, which method comprises suspending powder granules of said copolymer, formed by spr

The method for making an aqueous suspension of a synthetic resin copolymer, which suspension is adaptable to use for forming a coating on a medicament core to form an orally-ingestible pharmaceutical dosage unit form, which method comprises suspending powder granules of said copolymer, formed by spray drying an aqueous dispersion of said copolymer, in an aqueous solution of a plastizer for said copolymer or in an aqueous suspension of a plasticizer for said copolymer, said powder granules having a diameter between 20 and 60 microns and comprising loosely aggregated primary particles having a diameter of less than one micron, said copolymer comprising (a) 5 to 80 percent by weight of a water-soluble vinyl monomer selected from the group consisting of ab95 to 20 percent by weight of a monomer selected from the group consisting of styrene, vinyl acetate, olefins, and alkyl esters of acrylic acid and methacrylic acid having 1 to 10 carbon atoms in the alkyl portion thereof; the relative amounts of monomers (a) and (b) in said copolymer being such that the minimum film-forming temperature thereof is greater than 80°C., said copolymer further being water-insoluble in one portion of the region between pH 1.5 and 8 and water-soluble or water-swellable in another portion of said region.