초록 ▼

A process is described for the preparation of a novel protein product of a highly purified antihemophlic factor (AHF) concentrate. The product is prepared by use of a semi-permeable membrane apparatus that desalts the plasma to between 45 to 80% of its salt content while constantly maintaining the p

A process is described for the preparation of a novel protein product of a highly purified antihemophlic factor (AHF) concentrate. The product is prepared by use of a semi-permeable membrane apparatus that desalts the plasma to between 45 to 80% of its salt content while constantly maintaining the plasma at substantially its original starting pH level. Under these conditions the AHF portion of the plasma will precipitate.

대표청구항 ▼

A process for the separation and recovery of Factor VIII, von Willebrand\s factor, and Factor V from plasma and plasma derivative streams having a pH normally between about 6 to 8.5 comprising removing from said blood stream when present substantially all initial turbidity therein, subsequently pass

A process for the separation and recovery of Factor VIII, von Willebrand\s factor, and Factor V from plasma and plasma derivative streams having a pH normally between about 6 to 8.5 comprising removing from said blood stream when present substantially all initial turbidity therein, subsequently passing said blood plasma into and out of an apparatus containing one or more semi-permeable membranes which separate said plasma stream from a salt receiving stream thereby decreasing the salt content of said plasma stream between about 45 to 80% to cause the formation of a protein turbidity enriched in Factor VIII, von Willebrand\s factor and Factor V, subsequently removing substantially all of said turbidity and maintaining the temperature of said plasma stream during said separation and recovery process in the range of between about 4°-40°C., and at substantially its original starting pH level.