초록 ▼

A compound of the formula [Figure] wherein n is an integer from 2 to 4; m is an integer from 3 to 5; R is OM, OR1 or NR2R3 where M is a pharmaceutically acceptable cation; R1, R2 and R3 are the same or different and selected from the group consisting of hydrogen, C1-C12 branched, unbranched or cycli

A compound of the formula [Figure] wherein n is an integer from 2 to 4; m is an integer from 3 to 5; R is OM, OR1 or NR2R3 where M is a pharmaceutically acceptable cation; R1, R2 and R3 are the same or different and selected from the group consisting of hydrogen, C1-C12 branched, unbranched or cyclic alkyl, aryl and aralkyl; or R2 and R3 taken together form a group of the formula [Figure] can be used as an inhibitor of the lipoxygenase pathway of the arachidonic acid cascade in animals.

대표청구항 ▼

A compound of the formula [Figure] wherein n is an integer from 2 to 4; m is an integer from 3 to 5; R is OM, OR1 or NR2R3 where M is a pharmaceutically acceptable cation; R1, R2 and R3 are the same or different and selected from the group consisting of: hydrogen; C1-C12 branched, unbranched or cycl

A compound of the formula [Figure] wherein n is an integer from 2 to 4; m is an integer from 3 to 5; R is OM, OR1 or NR2R3 where M is a pharmaceutically acceptable cation; R1, R2 and R3 are the same or different and selected from the group consisting of: hydrogen; C1-C12 branched, unbranched or cyclic alkyl; phenyl, lower-alkyl substituted phenyl, halo-substituted phenyl and combinations thereof; and benzyl, lower alkyl substituted benzyl, and halo-substituted benzyl; or R2 and R3 taken together form a group of the formula: [Figure] A pharmaceutical composition comprising an amount sufficient to inhibit the lipoxygenase pathway of arachidonic acid metabolism of a compound of the formula: [Figure] wherein n is an integer from 2 to 4; n is an integer from 3 to 5; R is OM, OR1 or NR2R3 where M is a pharmaceutically acceptable cation; R1, R2 and R3 are the same or different and selected from the group consisting of: hydrogen; phenyl, lower-alkyl substituted phenyl, halo-substituted phenyl and combinations thereof; and benzyl, lower alkyl substituted benzyl and halo-substituted benzyl; or R2 and R3 taken together form a group of the formula: [Figure] together with an inert pharmaceutical carrier.