초록 ▼

Monoclonal antibodies specific to a mature human T cell surface antigen of molecular weight of about 120,000 daltons as determined by electrophoresis, the antigen not being modulated by monoclonal antibodies specific to it and being restricted within the human lymphoid system to the surface of matur

Monoclonal antibodies specific to a mature human T cell surface antigen of molecular weight of about 120,000 daltons as determined by electrophoresis, the antigen not being modulated by monoclonal antibodies specific to it and being restricted within the human lymphoid system to the surface of mature T cells, the monoclonal antibodies being capable of selectively binding mature human T cells and rendering them inactive in vivo and failing to induce the proliferation or activation of human lymphocytes.

대표청구항 ▼

A monoclonal antibody specific to a particular antigen on the surface of mature human T cells, said antigen being further characterized in that it has a molecular weight of about 120,000 daltons, as determined by carrying out electrophoresis on the antigen and comparing its movement with that of mar

A monoclonal antibody specific to a particular antigen on the surface of mature human T cells, said antigen being further characterized in that it has a molecular weight of about 120,000 daltons, as determined by carrying out electrophoresis on the antigen and comparing its movement with that of marker proteins of known molecular weight, it is not modulated by monoclonal antibodies specific to it, and it appears only on the surfaces of mature, and not immature, T cells, and said monoclonal antibody being further characterized in that it is produced by a hybrid cell comprising a murine lymphocyte, it is capable of selectively binding mature human T cells, it lyses mature human T cells in vitro in the presence of complement, and it fails to induce the proliferation or activation of human lymphocytes.