Evans John M. (Roydon GB2) Buckingham Robin E. (Welwyn Garden GB2) Willcocks Kenneth (Harlow GB2)
출원인 / 주소
Beecham Group p.l.c. (GB2 03)
인용정보
피인용 횟수 :
28인용 특허 :
1
초록▼
Compounds of formula (I): [Figure] (I) wherein: one of R1 and R2 is hydrogen and the other is selected from the class of alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, alkylsulphinyl, alkylsulphonyl, alkoxysulphinyl, alkoxysulphonyl, alkyl
Compounds of formula (I): [Figure] (I) wherein: one of R1 and R2 is hydrogen and the other is selected from the class of alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, alkylsulphinyl, alkylsulphonyl, alkoxysulphinyl, alkoxysulphonyl, alkylcarbonylamino, alkoxycarbonylamino, or aminosulphinyl, aminosulphonyl or aminocarbonyl, the amino moiety being optionally substituted by one or two alkyl groups, or alkylsulphinylamino, alkylsulphonylamino, alkoxysulphinylamino or alkoxysulphonylamino, or ethylenyl terminally substituted by alkylcarbonyl, nitro or cyano or -C(alkyl)NOH or -C(alkyl)NNH2, the alkyl groups or alkyl moieties of alkyl-containing groups having from 1 to 6 carbon atoms; one of R3 and R4 is hydrogen or alkyl having from 1 to 4 carbon atoms and the other is alkyl having from 1 to 4 carbon atoms, or R3 and R4 together with the carbon atom to which they are attached are spiroalkyl having from 3 to 6 carbon atoms; R5 is hydrogen, alkyl having from 1 to 3 carbon atoms or acyl having from 1 to 8 carbon atoms; and n is 1 or 2; the lactam group being trans to the OR5 group; have anti-hypertensive activity and are of use in the treatment of high blood pressure.
대표청구항▼
A compound of formula (I): [Figure] (I) wherein: one of R1 and R2 is hydrogen and the other is selected from the class of alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, alkylsulphinyl, alkylsulphonyl, alkoxysulphinyl, alkoxysulphonyl, alky
A compound of formula (I): [Figure] (I) wherein: one of R1 and R2 is hydrogen and the other is selected from the class of alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, alkylsulphinyl, alkylsulphonyl, alkoxysulphinyl, alkoxysulphonyl, alkylcarbonylamino, alkoxycarbonylamino, or aminosulphinyl, aminosulphonyl or aminocarbonyl, the amino moiety being optionally substituted by one or two alkyl groups, or alkylsulphinylamino, alkylsulphonylamino, alkoxysulphinylamino or alkoxysulphonylamino, or ethylenyl terminally substituted by alkylcarbonyl, nitro or cyano or -C(alkyl)NOH or -C(alkyl)NNH2, the alkyl groups or alkyl moieties of alkyl-containing groups having from 1 to 6 carbon atoms; one of R3 and R4 is hydrogen or alkyl having from 1 to 4 carbon atoms and the other is alkyl having from 1 to 4 carbon atoms, or R3 and R4 together with the carbon atom to which they are attached are spiroalkyl having from 3 to 6 carbon atoms; R5 is hydrogen, alkyl having from 1 to 3 carbon atoms or carboxylic acyl having from 1 to 8 carbon atoms; and n is 1 or 2; the lactam group being trans to the OR5 group. A pharmaceutical composition for treatment of hypertension in mammals, which comprises an anti-hypertensive effective amount of a compound of formula (I) according to claim 1, and a pharmaceutically acceptable carrier.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (1)
Evans John M. (Roydon GB2) Showell Graham A. (Harlow GB2) Fake Charles S. (Harlow GB2), Anti-hypertensive chromanol derivatives.
Englert Heinrich C. (Hofheim am Taunus DEX) Lang Hans-Jochen (Hofheim am Taunus DEX) Mania Dieter (Kelkheim DEX) Schlkens Bernward (Kelkheim DEX), Substituted 3,4-dihydro-2H-benzopyrans, processes for their preparation, their use and pharmaceutical products based on.
Evans John M. (Roydon GB2) Buckingham Robin E. (Welwyn Garden GB2) Willcocks Kenneth (Harlow GB2), Trans-3,4-dihydro-2,2-dimethyl-6-nitro-4-(2-oxo-pyrrolidinyl)2H-1-benzopyran-3-ol.
Evans John M. (Roydon GB2) Buckingham Robin E. (Welwyn Garden City GB2) Willcocks Kenneth (Harlow GB2), Trans-4-(2-thiaoxo-1-pyrrolidinyl or piperidinyl)-2H-benzo[b]pyran-3-ol derivatives useful in treating hypertension.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.