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Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/00
  • A61M-005/14
출원번호 US-0428899 (1982-09-30)
발명자 / 주소
  • Osterholm, Jewell L.
출원인 / 주소
  • Thomas Jefferson University
대리인 / 주소
    Woodcock, Washburn, Kurtz, Mackiewicz & Norris
인용정보 피인용 횟수 : 65  인용 특허 : 8

초록

A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqu

대표청구항

1. An apparatus for treating patients suspected of having hypoxic-ischemic central nervous system tissue, comprising: (a) a reservoir containing an oxygenatable fluorocarbon emulsion for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means disposed in fluid communication with said r

이 특허에 인용된 특허 (8)

  1. Lichtenstein Eric S. (420 Taconic Road Greenwich CT 06830), Apparatus for extracorporeal treatment of blood.
  2. Marx Alvin J. (Rochester NY) Edelman Abraham (New York NY), Automated intravenous fluid regulating and administering apparatus.
  3. Yin Chieh-Kung (Lindenhurst IL), Blood pressure alarm system for dialysis machines.
  4. Chabert Pierre (Saint Genis Laval FR) Foulletier Louis (Oullins FR) Lantz Andre (Oullins FR), Emulsification of fluorocarbon compounds for biological application as oxygen transporters.
  5. Corrales Mario (Artillergatan 45 Stockholm SW), Means for introducing and guiding objects into body cavities and blood vessels.
  6. Scherer Kirby V. (Santa Monica CA), Novel fluorohydrocarbons.
  7. Sorensen Soren K. (Glostrup DKX) Holbek Carl C. (Allerod DKX), Reference liquid for blood gas equipment.
  8. Lagow ; Richard J. ; Shimp ; Lawrence A. ; Clark ; Jr. ; Leland C., Tetramethylpentane blood substitutes.

이 특허를 인용한 특허 (65)

  1. Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  2. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  3. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  4. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  5. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  6. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  7. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  8. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Schein, Douglas; Harris, Stanley; Steibel, Dennis; Fraser, Richard; Isaacs, Dickon, Apparatus and method for maintaining and/or restoring viability of organs.
  9. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Schein, Douglas; Isaacs, Dickon, Apparatus and method for maintaining and/or restoring viability of organs.
  10. Klatz Ronald M. ; Goldman Robert M., Apparatus for cooling living tissue.
  11. Spears,J. Richard; Crilly,Richard; Rydman,Ray; Gessert,James; Myrick,Steve, Apparatus for oxygenating wastewater.
  12. Long ; Jr. David M. (El Cajon CA), Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal.
  13. Wagner David A. ; Woolf Graham M., Blood test for assessing hepatic function.
  14. Gijsbers, Johan F. M.; Gielen, Frans L. H., Brain fluid ion concentration modification for treating neurological disorders.
  15. Klatz Ronald M. (Chicago IL) Goldman Robert M. (Chicago IL), Brain resuscitation and organ preservation device and method for performing the same.
  16. Donald R. Owen, Brain resuscitation apparatus and method.
  17. Shaffer Thomas H. (Lansdowne PA) Wolfson Marla R. (Philadelphia PA) Miller Thomas F. (Philadelphia PA) Foust ; III Raymond (Philadelphia PA), Breathable liquid elimination analysis.
  18. Sweezer William Penn ; Jimison James ; Coleman Ronald L., Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery.
  19. Sweezer William Penn ; Jimison James ; Coleman Ronald L., Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery.
  20. Sweezer ; Jr. William P. ; Coleman Ronald ; Larkins ; III Walter W., Catheter system and method for total isolation of the heart.
  21. Osterholm Jewell L. (Radnor PA), Cerebral and lumbar perfusion catheterization apparatus for use in treating hypoxic/ischemic neurologic tissue.
  22. Lad, Shivanand; Mobley, William C.; Nikolich, Karoly; Saul, Thomas, Cerebrospinal fluid purification system.
  23. Lad, Shivanand; Mobley, William C.; Nikolich, Karoly; Saul, Thomas, Cerebrospinal fluid purification system.
  24. Federowicz Michael G. ; Klatz Ronald M., Combined liquid ventilation and cardiopulmonary resuscitation method.
  25. Wright, David Walter; Garland, Jeffrey C., Device for separating gas from a liquid path.
  26. Beyersdorf, Friedhelm, Device for treating an individual suffering from cardiac insufficiency, cardiac arrest, circulatory arrest or stroke.
  27. Beyersdorf, Friedhelm, Device for treating cardiac arrest.
  28. Machold,Timothy R.; Bloom,Nicole Denise; Roth,Alex T.; Scott,Dave J.; Alejandro,Jose; Oliver,Ed, Disposable cassette for intravascular heat exchange catheter.
  29. Long ; Jr. David M. (San Diego CA), Dissolution of gas in a fluorocarbon liquid.
  30. Kochanek, Patrick M; Wu, Xianren; Tisherman, Samuel Aaron; Stezoski, S. William; Yaffe, Lyn, Emergency preservation and resuscitation methods.
  31. Osterholm Jewell L. (Radnor PA), Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders.
  32. Sinnett Kevin B. (102 Kilps Court West Waukesha WI 53186) White Rodger L. (434 Lyman Oconomowoc WI 53066), Fluid and air infusion device.
  33. Osterholm Jewell L. (Radnor PA), Intra-peritoneal perfusion of oxygenated fluorocarbon.
  34. Osterholm Jewell L. (Radnor PA), Intra-peritoneal perfusion of oxygenated fluorocarbon.
  35. Fiddian-Green Richard G. (311 Awixa Ann Arbor MI 48104), Intraluminal membrane oxygenator method for a tubular organ of the gastrointestinal tract.
  36. Karin Kobuch DE; Veit-Peter Gabel DE; Joachim Dresp DE; Dirk-Henning Menz DE, Low-oxygen fluorocarbon as an agent for ophthalmology.
  37. Wright, David Walter; Schein, Douglas; Brassil, John, Method and apparatus for controlling air pressure in an organ or tissue container.
  38. Wright, David Walter; Schein, Douglas; Brassil, John, Method and apparatus for controlling air pressure in an organ or tissue container.
  39. Schein, Douglas; Travis, Lee William, Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container.
  40. Garland, Jeffrey C.; Schein, Douglas; Wright, David Walter, Method and apparatus for transferring heat to or from an organ or tissue container.
  41. Garland, Jeffrey C; Schein, Douglas; Wright, David Walters, Method and apparatus for transferring heat to or from an organ or tissue container.
  42. MacHold, Timothy R.; Keller, Wade A.; Roth, Alex T.; Bloom, Nicole Denise, Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter.
  43. Machold, Timothy R.; Keller, Wade A.; Roth, Alex T.; Bloom, Nicole Denise, Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter.
  44. Machold,Timothy R.; Keller,Wade A.; Roth,Alex T.; Bloom,Nicole Denise, Method and system for control of a patient's body temperature by way of transluminally insertable heat exchange catheter.
  45. Machold,Timothy R.; Keller,Wade A.; Roth,Alex T.; Bloom,Nicole Denise, Method and system for control of a patient's body temperature by way of transluminally insertable heat exchange catheter.
  46. Sweezer William Penn ; Jimison James ; Coleman Ronald L., Method for cannulating a patient's aortic arch and occluding the patient's ascending aortic arch.
  47. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Method for controlling perfusion of an organ.
  48. Spears,J. Richard; Crilly,Richard; Rydman,Ray; Gessert,James; Myrick,Steve, Method for oxygenating wastewater.
  49. Stevens John H. ; Sterman Wesley D. ; Gifford ; III Hanson S. ; Evard Philip C. ; Machold Timothy R., Method of delivering cardioplegic fluid to a patient's heart.
  50. Brassil, John; Schein, Douglas; Curtis, Christopher, Method of determining that an organ is not suitable for transplantation and using it for testing substances.
  51. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J; Fraser, Richard; Harris, Stanley; Schein, Douglas; Curtis, Christopher G., Method of determining transport and/or storage parameters for maintaining viability of an organ.
  52. William P. Sweezer, Jr. ; Ronald Coleman ; Walter W. Larkins, III, Method of occluding a patient's ascending aorta and delivery cardioplegic fluid.
  53. Owen, Donald R.; Kravitz, David C., Method of transporting and storing a kidney.
  54. Brian S. Donlon, Methods and devices for occluding a patient's ascending aorta.
  55. Donlon Brian S., Methods and devices for occluding a patient's ascending aorta.
  56. Sharkawy A. Adam ; Sterman Wesley D. ; Taylor David M. ; Ray Pinaki, Methods and devices for occluding the ascending aorta and maintaining circulation of oxygenated blood in the patient when the patient's heart is arrested.
  57. Sharkawy, A. Adam; Sterman, Wesley D.; Taylor, David M.; Ray, Pinaki, Methods and devices for occluding the ascending aorta and maintaining circulation of oxygenated blood in the patient when the patient's heart is arrested.
  58. Grimes, Kevin V.; Komtebedde, Jan; Rosenman, Daniel C.; Gifford, III, Hanson S.; Garrison, Michi E.; Sterman, Wesley D.; Taylor, David M.; Sharkawy, A. Adam; Ray, Pinaki, Methods and devices for occluding the ascending aorta and maintaining circulation oxygenated blood in the patient when the patient's heart is arrested.
  59. Timothy J. Corvi ; John H. Stevens, Multi-lumen catheter.
  60. Osterholm Jewell L. (Radnor PA), Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy.
  61. Loubser Paul Gerhard, Retrograde perfusion monitoring and control system.
  62. Dabrowiak, Jeremy, System and method for management of body temperature.
  63. Stevens John H. ; Evard Philip C. ; Machold Timothy R., System for cardiac procedures.
  64. Stevens John H. ; Sterman Wesley D. ; Gifford ; III Hanson S., System for cardiac procedures.
  65. Hesson, David P.; Pelura, Timothy J.; Frazer, Glen D., Treatment of neurological disease.
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