Branched amides of L-aspartyl-D-amino acid dipeptides
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07D-331/04
C07D-333/36
C07D-333/48
C07D-335/02
출원번호
US-0481495
(1983-04-01)
발명자
/ 주소
Brennan Thomas M. (Old Lyme CT) Hendrick Michael E. (Groton CT)
출원인 / 주소
Pfizer Inc. (New York NY 02)
인용정보
피인용 횟수 :
5인용 특허 :
1
초록▼
Amides of L-aspartyl-D-amino acid dipeptides of the formula [Figure] (I) and physiologically acceptable cationic and acid addition salts thereof wherein Ra is CH2OH or CH2OCH3; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethy
Amides of L-aspartyl-D-amino acid dipeptides of the formula [Figure] (I) and physiologically acceptable cationic and acid addition salts thereof wherein Ra is CH2OH or CH2OCH3; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, [Figure] where at least one of R3, R4, R5, R6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO2, C〓O or CHOH; m is zero or 1-4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R3, R4, R5 and R6 is not greater than six, and when both of R3 and R4 or R5 and R6 are alkyl they are methyl or ethyl, [Figure] where one of R7, R8, R9 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms and the sum of the carbon atoms in R7, R8 and R9 is not greater than six, m and q are the same or different and each have the values previously defined for m; [Figure] where each of R12 and R13 are methyl or ethyl, or R12 is hydrogen and R13 is alkyl having from one to four carbon atoms, Z is O or NH and t is 1 or 2, [Figure] where W is 1-4, R14 and R16 are each alkyl having from one to four carbon atoms, R15 is H, OH, methyl or ethyl and the sum of the carbon atoms in R14, R15 and R16 is not greater than six and when both of R14 and R15 are alkyl they are methyl or ethyl, and [Figure] where R17 and R19 are alkyl having from one to four carbon atoms, R18 and R20 are H or alkyl having one to two carbon atoms, A is OH and B is H, OH or CH3 and taken together A and B are [Figure] [Figure] where the sum of the carbon atoms in R17, R18, R19 and R20 is not greater than six and when both of R17 and R18 or R19 and R20 are alkyl they are methyl or ethyl; said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amide intermediates useful in their production.
대표청구항
A D-amino acid amide compound of the formula [Figure] wherein Ra is CH2OH or CH2OCH3, and Rc is [Figure] where X2 is S or SO2 and a. when n2 is zero and p2 is zero or 1, R41 and R61 are each methyl, b. when n2 is 1 and p2 is 1, R41 and R61 are each hydrogen.
A D-amino acid amide compound of the formula [Figure] wherein Ra is CH2OH or CH2OCH3, and Rc is [Figure] where X2 is S or SO2 and a. when n2 is zero and p2 is zero or 1, R41 and R61 are each methyl, b. when n2 is 1 and p2 is 1, R41 and R61 are each hydrogen.
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