초록 ▼

A self-supporting polymeric diffusion matrix provides for the sustained release of propranolol in order to deliver the propranolol to a patient. The matrix comprises from about 1 to about 60% of a polar plasticizer, from about 6 to about 30% by weight polyvinylalcohol, from about 2 to about 30% by w

A self-supporting polymeric diffusion matrix provides for the sustained release of propranolol in order to deliver the propranolol to a patient. The matrix comprises from about 1 to about 60% of a polar plasticizer, from about 6 to about 30% by weight polyvinylalcohol, from about 2 to about 30% by weight polyvinylpyrrolidone, and a pharmaceutically effective amount of propranolol to provide a sustained release of propranolol over a prolonged period.

대표청구항 ▼

A self-supporting polymeric diffusion matrix for the sustained release of propranolol to deliver transdermally said propanolol to a patient in need of a beta-andrenergic blocking agent, said matrix comprising from about 1 to about 60% of a polar plasticizer, from about 6 to about 30% by weight of at

A self-supporting polymeric diffusion matrix for the sustained release of propranolol to deliver transdermally said propanolol to a patient in need of a beta-andrenergic blocking agent, said matrix comprising from about 1 to about 60% of a polar plasticizer, from about 6 to about 30% by weight of at least 90% hydrolyzed polyvinyl alcohol molecular weight of about 50,000 to about 150,000, from about 2 to about 30% by weight polyvinylpyrrolidone molecular weight of about 15,000 to about 85,000, and a pharmaceutically transdermally effective amount of propanolol, a beta-adrenergic blocking agent indicated for the control of hypertension, arrhythmias and migraine, when applied to the skin of said patient.