초록 ▼

Apparatus for hemofiltration is disclosed, including a reverse osmosis module for purifying an impure supply of water, a container for adding concentrate thereto and preparing a replacement liquid, a semipermeable hemofiltration membrane filter for filtering the supply of blood and the replacement l

Apparatus for hemofiltration is disclosed, including a reverse osmosis module for purifying an impure supply of water, a container for adding concentrate thereto and preparing a replacement liquid, a semipermeable hemofiltration membrane filter for filtering the supply of blood and the replacement liquid in order to produce an ultrafiltrate stream and a filtered blood stream from the supply of blood and a filtrate stream from the replacement liquid so that the filtered blood and filtrate streams can be mixed and returned to the patient. An apparatus and method are also disclosed for monitoring fluid filtration in a semipermeable filtration membrane filter including a fluid inlet for supplying the fluid to the filter for contact with the semipermeable membrane to produce a filtrate therethrough, a fluid outlet for withdrawing the fluid from the filter subsequent to such contact, a filtrate outlet for withdrawal of the filtrate from the filter, a recirculation loop for returning the fluid withdrawn from the filter back to the fluid inlet, an indicator supply for adding an indicator which will not normally pass through the semipermeable membrane to the fluid in the recirculation loop, and a detector associated with the filtrate outlet for detecting the presence of the indicator in the filtrate stream.

대표청구항 ▼

Apparatus for hemofiltration of a supply of blood withdrawn from a patient and for the return to the patient of an infusate solution and filtered blood after hemofiltration, said apparatus comprising purified water supply means for purifying an impure supply of water provided from a source of impure

Apparatus for hemofiltration of a supply of blood withdrawn from a patient and for the return to the patient of an infusate solution and filtered blood after hemofiltration, said apparatus comprising purified water supply means for purifying an impure supply of water provided from a source of impure water which is separate from said supply of blood and adding concentrate thereto so as to provide a replacement liquid stream comprising a purified water stream including said concentrate, the amount of said replacement liquid stream being such that substantially the entire infusate solution to be returned to the patient is derived from said replacement liquid stream; filtration means for filtering said supply of blood and said replacement liquid stream, said filtration means comprising a first semipermeable hemofiltration membrane for hemofiltration of said supply of blood and a second semipermeable membrane for filtration of said replacement liquid stream; contact means for contacting said supply of blood and said replacement liquid stream with said filtration means so as to produce a filtered blood stream and an ultrafiltration stream from said supply of blood and an infusate filtrate stream from said replacement liquid stream, said contact means including blood inlet means for supplying said supply of blood to said first semipermeable hemofiltration membrane, replacement liquid inlet means for supplying said replacement liquid stream to said second semipermeable membrane, filtered blood outlet means for withdrawing said filtered blood stream from said first semipermeable hemofiltration membrane, ultrafiltrate outlet means for withdrawing said ultrafiltration stream from said first semipermeable hemofiltration membrane, filtrate outlet means for withdrawing said infusate filtrate stream from said second semipermeable membrane, and replacement liquid outlet means for withdrawing said replacement liquid stream which does not pass through said second semipermeable membrane from said second semipermeable membrane; return means for returning said filtered blood stream and said infusate filtrate stream to said patient whereby substantially the entire infusate solution returned to said patient is derived from said replacement liquid stream; and recirculation means for recirculating said replacement liquid stream withdrawn from said replacement liquid outlet means to said replacement liquid inlet means, said recirculation means including safety means for detecting failures in said second semipermeable membrane, said safety means comprising indicator supply means for supplying an indicator which will not normally pass through said second semipermeable membrane to said replacement liquid stream in said recirculation means, and detector means associated with said filtrate outlet means, said detector means being capable of detecting the presence of said indicator in said infusate filtrate stream.