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Recombinant monoclonal antibodies 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/00
  • G01N-033/54
  • G01N-033/60
  • G01N-033/76
출원번호 US-0279248 (1981-07-01)
발명자 / 주소
  • Reading Christopher L. (Kingwood TX)
출원인 / 주소
  • The University of Texas System Cancer Center (Houston TX 02)
인용정보 피인용 횟수 : 237  인용 특허 : 16

초록 ▼

Antibodies having binding affinity for two desired antigens, hereinafter “recombinant monoclonal antibodies”; recombinant monoclonal antibodies produced by a quadroma cell or a trioma cell; and methods for producing recombinant monoclonal antibodies by means of a quadroma cell or a trioma cell, wher

대표청구항 ▼

An antibody produced by a quadroma cell, wherein said antibody has specific binding affinity for two desired antigens and wherein said quadroma cell comprises the fusion product of: (a) a hyridoma cell which produces an antibody having specific binding affinity to one desired antigen, and (b) a hybr

이 특허에 인용된 특허 (16)

  1. Neville ; Jr. David M. (9624 Parkwood Dr. Bethesda MD 20014) Youle Richard J. (9629 Old Spring Rd. Kensington MD 20795), Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumor suppressant.
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  2. Bieber, Charles P.; Howard, Frank D., Anti-human T-lymphocyte monoclonal antibody.
    상세보기
  3. Galfre Giovanni (Cambridge GB2) Milstein Cesar (Cambridge GB2) Wright Bruce W. (Comberton GB2), Antibody production from hybrid cell line.
    상세보기
  4. Neville ; Jr. David M. (Bethesda MD) Youle Richard J. (Kensington MD) Murray Gary J. (Bethesda MD), Chemical modifications of proteins which induce new receptor specificities and therefore elicit new effects in cells.
    상세보기
  5. Kung Patrick C. (Bridgewater NJ) Goldstein Gideon (Short Hills NJ), Complement-fixing monoclonal antibody to human T cells, and methods of preparing same.
    상세보기
  6. Gillis Steven (15509 NE. 198th Woodinville WA 98072), Hybridoma antibody which inhibits interleukin 2 activity.
    상세보기
  7. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
    상세보기
  8. Hansen W. Peter (Middleboro MA) Hoffman Robert A. (Mansfield MA), Method and apparatus for automated identification and enumeration of specified blood cell subclasses.
    상세보기
  9. Koprowski Hilary (Wynnewood PA) Gerhard Walter U. (Philadelphia PA) Croce Carlo M. (Philadelphia PA), Method of producing antibodies.
    상세보기
  10. Koprowski Hilary (Wynnewood PA) Croce Carlo M. (Philadelphia PA), Method of producing tumor antibodies.
    상세보기
  11. Koprowski Hilary (Wynnewood PA) Mitchell Kenneth F. (Unionville PA) Steplewski Zenon (Strafford PA), Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen.
    상세보기
  12. Wands Jack R. (Waban MA) Zurawski ; Jr. Vincent R. (West Chester PA), Process for producing antibodies to hepatitis virus and cell lines therefor.
    상세보기
  13. Remington Jack S. (Palo Alto CA) Araujo Fausto G. (Palo Alto CA), Sandwich immunoassay and compositions for use therein.
    상세보기
  14. Goldenberg Milton D. (11837 Gainsborough Rd. Potomac MD 20854), Tumor localization and therapy with labeled anti-CEA antibody.
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  15. Goldenberg Milton D. (11837 Gainsborough Rd. Potomac MD 20854), Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers.
    상세보기
  16. Goldenberg Milton D. (11837 Gainsborough Rd. Potomac MD 20854), Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers.
    상세보기

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