초록 ▼

A multizone element, for quantitative analyte determination in whole blood, containing a porous spreading zone separated from a reagent zone by a barrier zone, said barrier zone comprising a non-porous film comprising a polymer of: from 30 to 95 percent by weight of polymerized monomer having the st

A multizone element, for quantitative analyte determination in whole blood, containing a porous spreading zone separated from a reagent zone by a barrier zone, said barrier zone comprising a non-porous film comprising a polymer of: from 30 to 95 percent by weight of polymerized monomer having the structure [Figure] from 0.25 to 30 percent by weight of polymerized monomer having the structure [Figure] and from 0.1 to 50 percent by weight of polymerized monomer having the structure [Figure] wherein: R1, R3, and R5 are independently selected from the group consisting of hydrogen and methyl, R2 is alkyl of from 1 to 16 carbon atoms, R4 and R6 are independently selected from the group consisting of alkylene groups having from 1 to 6 carbon atoms, [Figure] wherein R7 is hydrogen, alkyl of 1 to 10 carbon atoms, or cycloalkyl of 5 to 10 carbon atoms, and M is NR8R9H+X or SO3-X wherein R8 and R9 are independently selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and X is a counterion. A process for employing the element in analyses for analytes in whole blood is also disclosed.

대표청구항 ▼

A process, for quantitative analyte determination in whole blood, comprising bringing a sample of the blood into contact with a multizone element containing a porous spreading zone separated from a reagent zone by a barrier zone, said barrier zone comprising a non-porous film comprising a polymer of

A process, for quantitative analyte determination in whole blood, comprising bringing a sample of the blood into contact with a multizone element containing a porous spreading zone separated from a reagent zone by a barrier zone, said barrier zone comprising a non-porous film comprising a polymer of from 30 to 95 percent by weight polymerized monomer having the structure [Figure] from 0.25 to 30 percent by weight polymerized monomer having the structure [Figure] and from 0.1 to 50 percent by weight polymerized monomer having the structure [Figure] wherein: R1, R3, and R5 are independently selected from the group consisting of hydrogen and methyl, R2 is alkyl of from 1 to 16 carbon atoms, R4 and R6 are independently selected from the group consisting of alkylene groups having from 1 to 6 carbon atoms, [Figure] wherein R7 is hydrogen, alkyl of 1 to 10 carbon atoms, or cycloalkyl of 5 to 10 carbon atoms, and M is NR8R9H+X or SO3 -X wherein R8 and R9 are independently selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and X is a counterion.