초록 ▼

Biodegradable particles, with a diameter smaller than 500 nanometers, formed by the micellar polymerization of an alkyl-cyano-acrylate where the term “alkyl”means a lower alkyl radical having 1 to 4 carbon atoms and containing a biologically active substance. Also provided are processes for making p

Biodegradable particles, with a diameter smaller than 500 nanometers, formed by the micellar polymerization of an alkyl-cyano-acrylate where the term “alkyl”means a lower alkyl radical having 1 to 4 carbon atoms and containing a biologically active substance. Also provided are processes for making pharmaceutical compositions containing the biodegradable particles and using the particles in pharmaceutical and diagnostic applications.

대표청구항 ▼

Process of treating a mammal with a biologically active substance, said process comprising orally or parenterally administering to a mammal a biologically effective amount of biodegradable particles having a diameter less than 500 nanometers, said particles comprising a substantially spherical, dens

Process of treating a mammal with a biologically active substance, said process comprising orally or parenterally administering to a mammal a biologically effective amount of biodegradable particles having a diameter less than 500 nanometers, said particles comprising a substantially spherical, dense, filamentous, polymeric network, wherein the polymeric network has dispersed therethrough the biologically active substance, and wherein said polymer is biodegradable in the mammal and is formed by the micellar polymerization of an alkyl cyanoacrylate, said alkyl group containing 1 to 4 carbon atoms, wherein the polymer particles are biodegraded to progressively release the biologically active substance into said mammal at a rate substantially corresponding to the rate of biodegradation of said polymer. Process of carrying out a diagnostic test with a diagnostic agent, said process comprising adding to a biological medium to be analyzed a diagnostically sufficient amount of biodegradable particles having a diameter less than 500 nanometers, said particles comprising a substantially spherical, dense, filamentous, polymeric network, wherein the polymeric network has dispersed therethrough a diagnostic agent, and wherein said polymer is biodegradable in the medium and is formed by the micellar polymerization of an alkyl cyanoacrylate, said alkyl group containing 1 to 4 carbon atoms, and wherein the polymer particles are biodegraded in said medium to progressively release the diagnostic agent into said medium at a rate substantially corresponding to the rate of biodegradation of said polymer.