초록 ▼

Nylon coated microcapsules containing hydrophilic solvent-soluble anionic, cationic or quaternary drug salts were prepared by interfacial polycondensation techniques. In a first stage, the drug substance to be encapsulated is dissolved in an aqueous phase. Examples of drugs encapsulated are morphine

Nylon coated microcapsules containing hydrophilic solvent-soluble anionic, cationic or quaternary drug salts were prepared by interfacial polycondensation techniques. In a first stage, the drug substance to be encapsulated is dissolved in an aqueous phase. Examples of drugs encapsulated are morphine sulfate, diphenhydramine hydrochloride, and methantheline bromide. Next the aqueous drug solution is dispersed in an organic phase. In a second stage complementary polycondensation reactants each in an organic phase are added separately, either sequentially or simultaneously, to the dispersion prepared in the first stage. Microcapsules of nylon form around the hydrophilic solvent soluble core drug substance.

대표청구항 ▼

A process for the encapsulation of a hydrophilic core material in a membrane formed by interfacial polycondensation, the process comprising: in a first step, dispersing in a first continuous hydrophobic phase a hydrophilic phase comprising in solution the hydrophilic material to be encapsulated and

A process for the encapsulation of a hydrophilic core material in a membrane formed by interfacial polycondensation, the process comprising: in a first step, dispersing in a first continuous hydrophobic phase a hydrophilic phase comprising in solution the hydrophilic material to be encapsulated and a hydrophilic solvent or water; and then in a second stage, adding separately to the dispersion either sequentially or simultaneously, each of two complementary polycondensation monomer reactants: the first polycondensation monomer reactant comprising a hydrophobic solvent-soluble reagent; the second polycondensation monomer reactant comprising a hydrophilic solvent-soluble reagent dispersed in a second continuous hydrophobic phase; allowing the polycondensation monomers to react, the reaction effective to cause interfacial polymerization of a membrane encapsulating the hydrophilic phase containing the hydrophilic core material; and separating the encapsulated material from the continuous hydrophobic phase.