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Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-037/02
출원번호 US-0396213 (1982-07-08)
발명자 / 주소
  • Eppstein Deborah A. (Los Altos CA) Fraser-Smith Elizabeth B. (Los Altos CA) Matthews Thomas R. (Los Gatos CA)
출원인 / 주소
  • Syntex (U.S.A.) Inc. (Palo Alto CA 02)
인용정보 피인용 횟수 : 793  인용 특허 : 5

초록

Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides.

대표청구항 ▼

A method for enhancing the anti-infective activity of a muramyldipeptide (MDP) compound which method comprises serial intravenous injection to an animal in need thereof an anti-infective enhancing amount of unencapsulated MDP compound and liposomes within three hours of each other wherein said MDP c

이 특허에 인용된 특허 (5)

  1. Baldeschwieler John D. (Pasadena CA) Gamble Ronald C. (Pasadena CA) Mauk Marcia R. (Vancouver NJ CAX) Shen Tsung-Ying (Westfield NJ) Ponpipom Mitree M. (Branchburg NJ), Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances.
    상세보기
  2. Jones ; Gordon H. ; Moffatt ; John G. ; Nestor ; Jr. ; John J., Novel immunological adjuvant compounds and methods of preparation thereof.
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  3. Schneider Michel (Geneva CHX), Process for the preparation of liposomes in aqueous solution.
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  4. Adam Arlette (Palaiseau FRX) Audibert Francoise (Neuilly FRX) Chedid Louis (Paris FRX) Choay Jean (Paris FRX) Ciorbaru Rita (Montrouge FRX) Ellouz Fabrielle (Bagneux FRX) Juy Dominique (Paris FRX) Le, Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various ant.
    상세보기
  5. Adam Arlette (Palaiseau FRX) Audibert Francoise (Neuilly FRX) Chedid Louis (Paris FRX) Choay Jean (Paris FRX) Ciorbaru Rita (Montrouge FRX) Ellouz Fabrielle (Bagneux FRX) Juy Dominique (Paris FRX) Le, Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various an.
    상세보기

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  250. Marks, Daniel L.; Boppart, Stephen A., Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering.
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  258. Livingston, James A., Enzymatic debridement therapy for abnormal cell proliferation.
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  259. Armer, Thomas; McKinley, Geoff; Borland, Scott; Guzman, Miguel; Szabolcs, Ármin; Gerencser, János, Ergoline compounds and uses thereof.
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  263. Way,Jeffrey, Erythropoietin forms with improved properties.
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  300. Kahne Daniel Evan (Princeton NJ) Kahne Suzanne Walker (Princeton NJ), Glycosylated steroid derivatives for transport across biological membranes and process for making and using same.
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  308. Freeman, Gordon J.; Ahmed, Rafi; Jones, Timothy D.; Carr, Francis J.; Gregson, James P., Human anti-PD-1 antibodies and uses therefor.
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  319. Brown, Tracey J., Hyaluronan as a chemo-sensitizer in the treatment of cancer.
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  321. Brown, Tracey J., Hyaluronan-chemotherapeutic agent formulations for the treatment of colon cancer.
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  323. Breslow, Ronald; Miller, Thomas A.; Belvedere, Sandro; Marks, Paul A.; Richon, Victoria M.; Rifkind, Richard A., Hydroxamic acid compounds and methods of use thereof.
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  327. Fisher,Jed F.; Jacobs,Jon S.; Sherer,Brian, Hydroxypropylamines.
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  328. Ponath, Paul; Rao, Patricia; Rosenzweig, Michael; Smith, L. Mary; Ponte, Jose F., ILT3 binding molecules and uses therefor.
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  329. Ponath, Paul; Rosenzweig, Michael; Ponte, Jose F., ILT3 binding molecules and uses therefor.
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  330. Sahin, Ugur; Tureci, Ozlem; Koslowski, Michael; Usener, Dirk, Identification of tumor-associated antigens for diagnosis and therapy.
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  332. Ran, Chongzhao; Moore, Anna; Brownell, Anna-Liisa, Imaging brown adipose tissue with curcumin derivatives.
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  333. Wang, Yuan Yuan; Khoo, Kay Hooi; Chen, Shui Tein; Lin, Chun Cheng; Wong, Chi Huey; Lin, Chun Hung; Chen, Hong Sen; Tsai, Yow Fu, Immuno-modulating antitumor activities of (Reishi) polysaccharides.
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  334. Gillies, Stephen D.; Lo, Kin-Ming; Qian, Susan X., Immunocytokine sequences and uses thereof.
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  335. Gillies, Stephen D.; Lo, Kin-Ming; Qian, Susan Xiuqi, Immunocytokine sequences and uses thereof.
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  337. Kim, Jaeyun; Mooney, David J.; Li, Weiwei Aileen; Arany, Praveen; Gadish, Or, In situ antigen-generating cancer vaccine.
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  338. Stavros C. Manolagas ; Teresita Bellido, Increasing bone strength with selected bisphosphonates.
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  339. Vescovi, Angelo Luigi; Reynolds, Brent Allen, Inhibition of the tumorigenic potential of tumor stem cells by LIF and BMPs.
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  340. Markovitz, David; Mor-Vaknin, Nirit; Legendre, Maureen; Engelke, David; Benford, Kristine; Pai, Dave, Inhibitors of DEK protein and related methods.
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  341. Bencherif, Sidi A.; Sands, Roger Warren; Koshy, Sandeep T.; Mooney, David J., Injectable cryogel vaccine devices and methods of use thereof.
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  342. Bencherif, Sidi A.; Mooney, David J.; Edwards, David; Sands, Roger Warren, Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration.
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  343. Gantier, Rene; Vega, Manuel; Drittanti, Lila; Guyon, Thierry, Interferon-β mutants with increased anti-proliferative activity.
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  344. Zhang, Jian; Cook, Robert O., Iso-ergoline derivatives.
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  347. Armer, Thomas; McKinley, Geoff; Borland, Scott; Guzman, Miguel, Isoergoline compounds and uses thereof.
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  349. Armer, Thomas; McKinley, Geoff; Borland, Scott; Guzman, Miguel, Isoergoline compounds and uses thereof.
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  350. Strömberg, Roger; Honcharenko, Dmytro; Maity, Jyotirmoy; Juneja, Alok; Kurudenkandy, Firoz Roshan; Presto, Jenny; Dolfe, Lisa; Fisahn, André; Johansson, Jan; Nilsson, Lennart, Ligands for prevention of neurotoxicity of the alzheimer's disease related amyloid-beta peptide.
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  351. Byra Anna ; Burzynski Stanislaw R. ; Waldbillig Robert J., Liposomal antineoplaston therapies with markedly improved antineoplastic activity.
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  352. Anderson Peter M. (St. Louis Park MN) Leonard Arnold S. (Minneapolis MN) Ochoa Augusto C. (Minneapolis MN) Loeffler Cynthia (Woodbury MN), Liposome immunoadjuvants containing IL-2.
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  353. Anderson Peter M. ; Leonard Arnold S. ; Ochoa Augusto C. ; Loeffler Cynthia, Lipsome containing IL-2.
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  354. Boppart, Stephen A.; Nguyen, Freddy T.; Zysk, Adam M., Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors.
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  355. Hostetler, Karl Y.; Beadle, James R., Lung-targeted drugs.
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  356. Hostetler, Karl Y.; Beadle, James R., Lung-targeted drugs.
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  357. Ortega Muñoz, Alberto; Castro-Palomino Laria, Julio; Fyfe, Matthew Colin Thor, Lysine Specific Demethylase-1 inhibitors and their use.
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  358. Baker, Jonathan A.; Fyfe, Matthew Collin Thor, Lysine demethylase inhibitors for diseases and disorders associated with Flaviviridae.
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  359. Baker, Jonathan Alleman; Fyfe, Matthew Colin Thor, Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae.
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  360. Baker, Jonathan Alleman; Castro Palomino, Julio; Fyfe, Matthew Colin Thor; Maes, Tamara; Martinell Pedemonte, Marc, Lysine demethylase inhibitors for myeloproliferative disorders.
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  361. Muñoz, Alberto Ortega; Castro-Palomino Laria, Julio; Fyfe, Matthew Colin Thor, Lysine specific demethylase-1 inhibitors and their use.
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  362. Muñoz, Alberto Ortega; Castro-Palomino Laria, Julio; Fyfe, Matthew Colin Thor, Lysine specific demethylase-1 inhibitors and their use.
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  363. Ortega Munoz, Alberto; Castro-Palomino Laria, Julio; Fyfe, Matthew Colin Thor, Lysine specific demethylase-1 inhibitors and their use.
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  364. LeBowitz, Jonathan H.; Maga, John, Lysosomal targeting peptides and uses thereof.
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  365. LeBowitz, Jonathan; Maga, John, Lysosomal targeting peptides and uses thereof.
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  366. Yannoni,Yvonne M.; Lin,Lih Ling, MK2 interacting proteins.
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  367. Kufe, Donald W., MUC1-IκB kinase complexes and their activities.
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  368. Oldenburg, Amy L.; Boppart, Stephen A.; Crecea, Vasilica; Liang, Xing, Magnetomotive optical coherence tomography.
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  369. Cao, Lan; Bouhadir, Kamal H.; Mooney, David J., Materials presenting notch signaling molecules to control cell behavior.
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  370. Kim, Jaeyun; Li, Weiwei Aileen; Mooney, David J., Mesoporous silica compositions for modulating immune responses.
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  371. Zysk, Adam M.; Adie, Steven G.; Leigh, Matthew S.; Armstrong, Julian J.; Sampson, David D.; Boppart, Stephen A., Method and apparatus for measurement of optical properties in tissue.
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  372. Szeto, Hazel; Zhao, Kesheng; Robertson, Hugh; Birk, Alex V., Method and carrier complexes for delivering molecules to cells.
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  373. Newman, Gale; Jacob-Mungin, Barbara A.; Obialo, Chamberlain, Method and compositions for the treatment and detection of endothelin-1 related kidney diseases.
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  374. Zeichner, Steven L.; Fernandez, Guerau, Method and compositions for treating HIV infection.
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  375. Kong, Xianqi; Wu, Xinfu; Bouzide, Abderrahim; Valade, Isabelle; Migneault, David; Gervais, Francine; Delorme, Daniel; Bachand, Benoit; Atfani, Mohamed; Levesque, Sophie; Samim, Bita, Method and compositions for treating amyloid-related diseases.
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  376. Eppstein Deborah A. (Palo Alto CA) Fraser-Smith Elizabeth (Los Altos CA) Matthews Thomas R. (Los Gatos CA), Method for enhancing the anti-infective activity of muramyldipeptide derivatives.
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  377. Tavarekere, Girish S; Balasubramanian, Gopal, Method for identifying inhibitors of Staphylococcus aureus.
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  378. LeBowitz, Jonathan H.; Beverley, Stephen M., Method for targeting lysosomal enzymes.
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  379. Bates, Paula J.; Miller, Donald M.; Trent, John O.; Xu, Xiaohua, Method for the diagnosis and prognosis of malignant diseases.
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  380. Bates, Paula J.; Miller, Donald M.; Trent, John O.; Xu, Xiaohua, Method for the diagnosis and prognosis of malignant diseases.
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  381. Bates,Paula J.; Miller,Donald M.; Trent,John O.; Xu,Xiaohua, Method for the diagnosis and prognosis of malignant diseases.
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  382. Miller, Donald M.; Bates, Paula J.; Trent, John O.; Xu, Xiaohua, Method for the diagnosis and prognosis of malignant diseases.
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  383. Amara,Ali; Arenzana Seisdedos,Fernando; Despres,Philippe; Virelizier,Jean Louis, Method of inhibiting binding of Dengue virus to a human cell with DC-SIGN blockers.
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  384. Himawan,Jeff, Method of producing bispecific molecules by protein trans-splicing.
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  385. Qiu, Xiao-Qing, Method of producing the polypeptide for treating virus-induced cancer.
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  386. Amara,Ali; Halary,Frank; Dechanet Merville,Julie; Moreau,Jean Francois; Arenzana Seisdedos,Fernando; Delaunay,Thierry, Method of treating cytomegalovirus with DC-SIGN blockers.
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  387. Verner, Erik Joel, Method of treating glaucoma.
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  388. Casey, John L.; Korba, Brent E.; Cote, Paul J.; Gerin, John L.; Tennant, Bud C.; Chu, Chung K., Method of treating hepatitis delta virus infection.
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  389. Casey,John L.; Korba,Brent E.; Cote,Paul J.; Gerin,John L.; Tennant,Bud C.; Chu,Chung K., Method of treating hepatitis delta virus infection.
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  390. Qiu, Xiao-Qing, Method of treating virus-induced cancer.
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  391. Hua, Kuo-Feng; Hsu, Hsien-Yeh; Wong, Chi-Huey, Methods and compositions associated with administration of an extract of.
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  392. Kim, Sung K.; Deciu, Cosmin, Methods and compositions for analyzing nucleic acid.
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  393. Wilson, D. Travis, Methods and compositions for detecting and diagnosing diseases and conditions.
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  394. Liu, Liping; Tang, Shibo; Liang, Xiaoling, Methods and compositions for preventing or treating ophthalmic conditions.
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  395. Liu, Liping; Tang, Shibo; Liang, Xiaoling, Methods and compositions for preventing or treating ophthalmic conditions.
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  396. Liu, Liping; Tang, Shibo; Liang, Xiaoling, Methods and compositions for preventing or treating ophthalmic conditions.
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  397. Liu, Liping; Tang, Shibo; Liang, Xiaoling, Methods and compositions for preventing or treating ophthalmic conditions.
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  398. Smith, Maree T., Methods and compositions for reducing the risk associated with the administration of opioid analgesics in patients with diagnosed or undiagnosed respiratory illness.
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  399. Wilson, D. Travis; Kloner, Robert A., Methods and compositions for regulating SRCA2A expression levels in myocardial infarction.
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  400. LeBowitz, Jonathan, Methods and compositions for targeting proteins across the blood brain barrier.
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  401. Wilson, D. Travis; Bamberger, Mark, Methods and compositions for the prevention or treatment of barth syndrome.
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  402. Ammann Arthur J. (San Rafael CA), Methods and compositions for the treatment of lung conditions.
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  403. Desrosiers, Ronald; Shin, Young, Methods and compositions for transgene expression in a herpesvirus vector system.
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  404. Kong, Xianqi; Migneault, David; Valade, Isabelle; Wu, Xinfu; Gervais, Francine, Methods and compositions for treating amyloid-related diseases.
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  405. Kong, Xianqi; Szarek, Walter A.; Gervais, Francine, Methods and compositions for treating amyloid-related diseases.
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  406. Kong, Xianqi; Wu, Xinfu; Bouzide, Abderrahim; Valade, Isabelle; Migneault, David; Gervais, Francine; Delorme, Daniel; Bachand, Benoit; Atfani, Mohamed; Levesque, Sophie; Samim, Bita, Methods and compositions for treating amyloid-related diseases.
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  407. Kong,Xianqi; Migneault,David; Valade,Isabelle; Wu,Xinfu; Gervais,Francine, Methods and compositions for treating amyloid-related diseases.
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  408. Kong,Xianqi; Szarek,Walter A.; Gervais,Francine, Methods and compositions for treating amyloid-related diseases.
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  409. Sommadossi, Jean-Pierre; LaColla, Paolo, Methods and compositions for treating flaviviruses and pestiviruses.
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  410. Sommadossi, Jean-Pierre; LaColla, Paulo, Methods and compositions for treating flaviviruses and pestiviruses.
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  411. Sommadossi, Jean Pierre; LaColla, Paulo, Methods and compositions for treating hepatitis C virus.
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  412. Sommadossi, Jean-Pierre; LaColla, Paulo, Methods and compositions for treating hepatitis C virus.
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  413. Gosselin,Gilles; Imbach,Jean Louis; Sommadossi,Jean Pierre, Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides.
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  414. Kufe, Donald W., Methods and compositions relating to promoter regulation by MUC1 and KLF proteins.
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  415. Kufe, Donald W., Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3.
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  416. Kufe, Donald W., Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins.
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  417. Medford, Russell M.; Saxena, Uday, Methods and compositions to lower plasma cholesterol levels.
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  418. Nichols, Pilarin Elizabeth; Luisi, Donna L., Methods and compositions with reduced opalescence.
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  419. Kahne, Daniel Evan; Kahne, Suzanne Walker; Gampe, Christian M.; Tsukamoto, Hirokazu, Methods and compounds for identifying glycosyltransferase inhibitors.
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  420. Szarek, Walter A.; Weaver, Donald F.; Kong, Xianqi; Gupta, Ajay; Migneault, David, Methods and compounds for inhibiting amyloid deposits.
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  421. Szarek, Walter A.; Weaver, Donald F.; Kong, Xianqi; Gupta, Ajay; Migneault, David, Methods and compounds for inhibiting amyloid deposits.
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  422. Szarek,Walter A.; Weaver,Donald F.; Kong,Xianqi; Gupta,Ajay; Migneault,David, Methods and compounds for inhibiting amyloid deposits.
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  423. Cantor, Charles R.; DeSantis, Grace; Mueller, Reinhold; Ehrich, Mathias, Methods and processes for non-invasive assessment of genetic variations.
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  424. Sherwood, Steven W., Methods for detecting targets.
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  425. Twine, Natalie C.; Burczynski, Michael E.; Trepicchio, William L.; Dorner, Andrew J.; Stover, Jennifer A.; Slonim, Donna K., Methods for diagnosing RCC and other solid tumors.
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  428. Nadine A. Tatton ; William G. Tatton, Methods for increasing schwann cell survival.
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  430. Keith, Dennis; Lai, Jan-Ji; Govardhan, Chandrika; Khalaf, Nazer, Methods for preparing purified lipopeptides.
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  435. Szeto, Hazel H.; Felsen, Diane, Methods for prevention and treatment of acute renal injury.
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  436. Szeto, Hazel H.; Felsen, Diane, Methods for prevention and treatment of acute renal injury.
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  437. Szeto, Hazel H.; Liu, Shaoyi; Cho, Sunghee, Methods for reducing CD36 expression.
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  438. Szeto, Hazel H.; Liu, Shaoyl; Cho, Sunghee, Methods for reducing CD36 expression.
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  439. Carter Bruce L. A. (Mercer Island WA) Edwards Martin W. (Woodinville WA), Methods for reducing blood loss.
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  440. Bookbinder, Louis; Kundu, Anirban; Frost, Gregory I., Methods for reducing intraocular pressure by administering a soluble hyaluronidase glycoprotein (sHASEGP).
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  441. Szeto, Hazel, Methods for reducing oxidative damage.
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  442. Szeto, Hazel H., Methods for reducing oxidative damage.
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  444. Long, Xiangtian; Dai, Danmei; Brunner, Andreas; Watt, Derek Kevin; Clinch, Keith; Baars, Sylvia Myrna; Dixon, Rachel Anne; Little, Gillian Mary; Landreau, Cyrille Abel Sébastien; Proisy, Nicolas Georges Rene, Methods for synthesizing molybdopterin precursor Z derivatives.
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  445. Tompkins, Ronald G.; Tzika, A. Aria; Yu, Yong-Ming; Rahme, Laurence; Martyn, Jeevendra A., Methods for the prevention and treatment of burn injuries and secondary complications.
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  446. Wilson, D. Travis; Borow, Kenneth; Kloner, Robert A.; Hale, Sharon, Methods for the prevention or treatment of no-reflow following ischemia/reperfusion injury.
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  447. Wilson, D. Travis; Kloner, Robert A., Methods for the regulation of matrix metalloproteinase expression.
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  448. Khalifah, Raja G.; Keilitz, Roland; Koellner, Christoph; Degenhardt, Thorsten; Brand, Stephen Robert, Methods for the synthesis of pyridoxamine.
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  451. Bookbinder, Louis; Kundu, Anirban; Frost, Gregory I., Methods for treating edema by administering a Soluble Hyaluronidase Glycoprotein (sHASEGP).
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  452. Hajjar, Roger J.; Lompr, Anne-Marie; Lipskaia, Larissa; del Monte, Federica, Methods for treating restenosis.
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  453. Wilson, D. Travis; Bamberger, Mark; Blakey, Brian, Methods for treatment of atherosclerosis.
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  455. Chen, Yinpu; Garmey, Edward G.; Schwartz, Brian, Methods for treatment of non-small cell lung cancer.
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  456. Letai, Anthony G., Methods of determining cellular chemosensitivity.
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  457. Rothenberg, Marc E.; Caldwell, Julie, Methods of determining eosinophilic gastritis status based on marker or gene expression.
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  458. Ferber, Sarah, Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues.
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  462. Sexton, Daniel J.; TenHoor, Christopher; Viswanathan, Malini, Methods of producing antibodies to neonatal Fc receptor (FcRn).
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  463. Cockett, Mark; Ramanathan, Chandra S.; Lodge, Nicholas J.; Fitzgerald, Kevin; Stouch, Terry; Moore, Lisa; Kindt, Rachel M.; Kopczynski, Jenny; Doberstein, Stephen Kohl, Methods of screening for agents that modulate the interaction of RGS and Gαq and urinary incontinence.
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  464. Ferber, Sarah, Methods of transdifferentiation and methods of use thereof.
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  465. Pellman, David, Methods of treating a meiotic kinesin associated disease.
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  468. Rothenberg, Marc E.; Caldwell, Julie, Methods of treating allergic inflammatory conditions by administering an anti-cadherin-like 26-based therapeutic.
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  471. Gjorstrup, Per, Methods of treating ototoxicity.
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  474. Williams, Dustin; Looper, Ryan; Jeyapalina, Sujeevini; Haussener, Travis; Sebahar, Paul R.; Reddy, Hari Kanna, Methods of use comprising a biocidal polyamine.
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  476. Hom,Roy; Mamo,Shumeye S.; Tung,Jay; Gailunas,Andrea; John,Varghese; Fang,Lawrence Y., Methods to treat alzheimer's disease.
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  477. Kong, Xianqi; Atfani, Mohamed; Bachand, Benoit; Bouzide, Abderrahim; Ciblat, Stephane; Levesque, Sophie; Migneault, David; Valade, Isabelle; Wu, Xinfu; Delorme, Daniel, Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid.
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  479. Wu, Libo; Zhang, Jian, Methysergide derivatives.
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  480. Marasco, Wayne A.; Tang, Xiangchun, Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof.
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  487. Corcoran,Christopher John; Flannery,Carl R.; Zeng,Weilan; Racie,Lisa A.; McDonagh,Thomas; Freeman,Bethany A.; Georgiadis,Katy E.; LaVallie,Edward R., Modified ADAMTS4 molecules and method of use thereof.
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  488. Madison, Edwin L.; Nguyen, Jack; Ruggles, Sandra Waugh; Thanos, Christopher, Modified MT-SP1 proteases that inhibit complement activation.
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  500. Fan, Daping, Modulation of macrophage phenotype by emodin.
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  501. Lindquist, Per; Mercer, Alex; Rönnholm, Harriet; Wikström, Lilian, Modulation of neural stem cells and neural progenitor cells.
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  505. Wang, Yue; Xu, Xiao-Li; Lee, Raymond Teck Ho, Modulators of Candida hyphal morphogenesis and uses thereof.
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  510. Kahne, Daniel Evan; Kahne, Suzanne Walker; Tsukamoto, Hirokazu, Moenomycin analogs, methods of synthesis, and uses thereof.
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  525. Boppart, Stephen A.; Wei, Alexander, Multi-functional plasmon-resonant contrast agents for optical coherence tomography.
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  526. Barr, Philip J.; Gibson, Helen L.; Pemberton, Philip A., Multifunctional protease inhibitors and their use in treatment of disease.
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  530. John, Varghese; Maillard, Michel; Jagodzinska, Barbara; Beck, James; Gailunas, Andrea; Freskos, John; Mickelson, John; Samala, Lakshman; Sealey, Jennifer; Tenbrink, Ruth; Fang, Larry; Hom, Roy, N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives.
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  531. Chan Ming Fai ; Wu Chengde ; Raju Bore Gowda ; Kogan Timothy ; Kois Adam ; Verner Erik Joel ; Castillo Rosario Silvestre ; Yalamoori Venkatachalapathi ; Balaji Vitukudi Narayanaiyengar, N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin.
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  532. Otto,Michael J.; Shi,Junxing; Watanabe,Kyoichi A., N-acylcytosine nucleosides for treatment of viral infections.
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  533. Otto, Michael J.; Shi, Junxing; Watanabe, Kyoichi A., N4-acylcytosine nucleosides for treatment of viral infections.
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  545. Madison,Edwin L.; Yeh,Jiunn Chern, Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon.
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  548. Oeth, Paul Andrew; Mahboubi, Payam; Lee, Min Seob, Nucleic acid-based tests for prenatal gender determination.
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  549. Valge-Archer, Viia; Williams, Andrew James; Young, Deborah A.; Whitters, Matthew J.; Collins, Mary; Witek, Joann, Nucleic acids coding for antibodies against human IL-21 receptor and uses therefor.
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  550. Madison,Edwin L.; Ong,Edgar O., Nucleic acids encoding endotheliases, endotheliases and uses thereof.
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  551. Qiu, Xiao-Qing, Nucleic acids molecule encoding the polypeptide for treating virus-induced cancer.
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  552. Huang, Raven H.; Liu, Xianjun, Nucleoside analog inhibitors of reverse transcriptase.
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  553. Schinazi Raymond F. ; Fulcrand-El Kattan Geraldine ; Lesnikowski Zbigniew Jan, Nucleosides and oligonucleotides containing boron clusters.
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