Churchill Jeffrey R. (Northwich GBX) Hutchinson Francis G. (Lymm GBX)
출원인 / 주소
Imperial Chemical Industries PLC (London GB2 03)
인용정보
피인용 횟수 :
286인용 특허 :
5
초록▼
Pharmaceutical compositions comprising a pharmacologically active polypeptide and a pharmacologically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block copolymer, which has a minimum weight average molecular weight of 5,000, in which the hydrophobic component i
Pharmaceutical compositions comprising a pharmacologically active polypeptide and a pharmacologically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block copolymer, which has a minimum weight average molecular weight of 5,000, in which the hydrophobic component is biodegradable and the hydrophilic component may or may not be biodegradable, the composition being capable of absorbing water to form a hydrogel when placed in an aqueous, physiological-type environment; copolymers suitable for use in said compositions; and method for the manufacture of such copolymers.
대표청구항▼
A pharmaceutically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block copolymer, which has a minimum weight average molecular weight of 5,000, in which the hydrophobic component is biodegradable or hydrolytically unstable under normal physiological conditions, a
A pharmaceutically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block copolymer, which has a minimum weight average molecular weight of 5,000, in which the hydrophobic component is biodegradable or hydrolytically unstable under normal physiological conditions, and the hydrophilic component may or may not be biodegradable, the coplymer being capable of absorbing water to form a hydrogel when placed in water or an aqueous physiological-type environment in an animal body, the amphipathic copolymer being a linear block copolymer of the formula Am(BA)n or Bm(AB)n wherein m is 0 or 1, n is an integer, A is a pharmaceutically or veterinarily acceptable hydrophobic polymer and B is a pharmaceutically or veterinarily acceptable hydrophilic polymer, or the amphipathic copolymer is a graft or branched block copolymer of the formula ABn or BAn wherein A, B and n have the meanings stated above and wherein respectively either A or B is a backbone polymer with n units of a monomer or polymer B or A respectively grafted onto it, and wherein A is selected from poly (D-, L- and DL-lactic acids), poly (D-, L- and DL-lactides), polyglycolic acid, polyglycolide, poly- caprolactone, poly(3-hydroxy-butyric acid), non-therapeutic hydrophobic polypeptides, polyacetals of the formula: [Figure] wherein R is a hydrocarbon radical, and n has the meaning stated above, polycarbonates or polyorthoesters of the formula: [Figure] wherein R and n have the meanings stated above, and copolymers of the formula: [Figure] wherein R and n have the meanings stated above, and copolymers derived from two or more monomers from which the above polymers are derived; and the pharmaceutically or veterinarily acceptable hydrophilic polymer B is selected from polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, polyacrylamide, polymethacrylamide, dextran, alginic acid, sodium alginate, and gelatine, and copolymers of two or more of the monomers from which the above polymers are derived, and polyoxyethylene/polyoxypropylene block copolymers.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (5)
Okuzumi Yuzi (Belle Mead NJ) Mellon A. Darline (Bridgewater NJ) Wasserman David (Springfield NJ), Addition copolymers of lactide and glycolide and method of preparation.
Vert Michel (Deville-les-Rouen FRX) Chabot Francois (Rouen FRX) Leray Jean (Sevres FRX) Christel Pascal (Paris FRX), New prosthesis parts, their preparation and their application.
Tu, Bailin; Ziemann, Robert N.; Tieman, Bryan C.; Hemken, Philip M.; Ramsay, Carol S.; Strobel, Carolyn J.; Hawksworth, David J.; Birkenmeyer, Larry G.; Zhao, Cheng; Brophy, Susan E.; Dowell, Barry L.; Muerhoff, Anthony S., Anti-GP73 monoclonal antibodies and methods of obtaining the same.
Lacy, Susan E.; Barbon, Jeffrey A.; Chhaya, Meha; Fung, Emma; Hutchins, Charles W.; Lang, Diane M.; Barlow, Eve H.; Leddy, Mary; Chari, Ravi, Anti-NGF antibodies and their use.
Lacy, Susan E.; Barbon, Jeffrey A.; Chhaya, Meha; Fung, Emma; Hutchins, Charles W.; Lang, Diane M.; Barlow, Eve H.; Leddy, Mary; Chari, Ravi, Anti-NGF antibodies and their use.
Curran, William V.; Liu, Christopher M.; Bombardier, Amy C. D.; Leese, Richard A.; Hwang, You Seok; Lippa, Blaise S.; Zhang, Yanzhi, Antibiotic compositions for the treatment of gram negative infections.
Mueller, Bernhard K.; Schmidt, Martin; Barlow, Eve; Leddy, Mary; Hsieh, Chung-Ming; Bardwell, Philip, Antibodies against the RGM A protein and uses thereof.
Mueller, Bernhard K.; Schmidt, Martin; Barlow, Eve; Leddy, Mary; Hsieh, Chung-Ming; Bardwell, Philip, Antibodies against the RGM a protein and uses thereof.
Brophy, Susan E.; Tu, Bailin; Tyner, Joan D.; Tyner, legal representative, Lowell J.; Huang, Dagang; Ziemann, Robert N., Antibodies to troponin I and methods of use thereof.
Bonvini, Ezio; Johnson, Leslie S.; Huang, Ling; Moore, Paul A.; Chichili, Gurunadh Reddy; Alderson, Ralph Froman, Bi-specific monovalent diabodies that are capable of binding CD123 and CD3, and uses thereof.
Moore, Paul A.; Li, Jonathan; Chen, Francine Zhifen; Johnson, Leslie S.; Shah, Kalpana; Bonvini, Ezio, Bi-specific monovalent diabodies that are capable of binding to gpA33 and CD3, and uses thereof.
Muller, Bernhard K.; Schaffar, Gregor; Mueller, Reinhold, Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use.
Alan M. Polson ; Deryl D. Swanbom ; Richard L. Dunn ; Charles P. Cox ; Richard L. Norton ; Bryan K. Lowe ; Kenneth S. Peterson, Biodegradable implant precursor.
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable polymer composition.
Lacy, Susan E.; Barbon, Jeffrey A.; Chhaya, Meha; Fung, Emma; Hutchins, Charles W.; Lang, Diane M.; Barlow, Eve H.; Leddy, Mary; Chari, Ravi, Caninized anti-NGF antibodies and their use.
Jarrett Peter K. (New Haven CT) Jessup George (Brookfield CT) Rosati Louis (Norwalk CT) Martin Chris (Guildford AUX) Maney John W. (Spring Valley NY), Coating for tissue drag reduction.
Hubbell, Jeffrey A.; Pathak, Chandrashekhar P.; Sawhney, Amarpreet S.; Desai, Neil P.; Hill, Jennifer L.; Hossainy, Syed F. A., Coating substrates by polymerizing macromers having free radical-polymerizable substituents.
Mueller, Bernhard; Huang, Lili; Bardwell, Philip D.; Kutskova, Yuliya; Memmott, John, Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration.
Beligere, Gangamani S.; Manoj, Shamila; Brate, Elaine M.; Grenier, Frank C.; Hawksworth, David J.; Ziemann, Robert N.; Birkenmeyer, Larry G.; Mueller, Bernhard; Popp, Andreas; Brophy, Susan, Composition and method for the diagnosis and treatment of iron-related disorders.
Peddareddigari,Vijay Gopal Reddy; Lim,Tai Tian; El Oakley,Reida Menshawe, Composition derived from biological materials and method of use and preparation.
Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Composition for delivering bioactive agents for immune response and its preparation.
Chanen Michael J. ; van Bommel Bernhard George,BEX ; Gruber Patrick R., Conditioned fertilizer product, method for conditioning fertilizer, and method for using conditioned fertilizer product.
Chandrashekar Bhagya L. ; Zhou Mingxing ; Jarr Eileen M. ; Dunn Richard L., Controlled release liquid delivery compositions with low initial drug burst.
Bonvini, Ezio; Johnson, Leslie S.; Shah, Kalpana; La Motte-Mohs, Ross; Moore, Paul A.; Koenig, Scott, Covalently bonded diabodies having immunoreactivity with PD-1 and LAG-3, and methods of use thereof.
Magruder, Judy A.; Eckenhoff, James B.; Cortese, Richard; Wright, Jeremy C.; Peery, John R., Delivery system comprising first walled section and second walled section united by fusion, adhesion or telescopic engagement.
Magruder Judy A. (Mt. View CA) Eckenhoff James B. (Los Altos CA) Cortese Richard (Los Gatos CA) Wright Jeremy C. (Los Altos CA) Peery John R. (Palo Alto CA), Delivery system comprising means for governing fluid into the system and for restricting fluid into the system.
Magruder, Judy A.; Eckenhoff, James B.; Cortese, Richard; Wright, Jeremy C.; Peery, John R., Delivery system comprising two sections for delivering somatotropin.
Eckenhoff James B. (Los Altos CA) Magruder Judy A. (Mt. View CA) Cortese Richard (Cupertino CA) Peery John R. (Palo Alto CA) Wright Jeremy C. (Los Altos CA), Device comprising liner for protecting fluid sensitive medicament.
Magruder Judy A. (Mt. View CA) Eckenhoff James B. (Los Altos CA) Cortese Richard (Los Gatos CA) Wright Jeremy C. (Los Altos CA) Peery John R. (Palo Alto CA), Dispenser for increasing feed conversion of hog.
Johnson, Leslie S.; Rainey, Godfrey Jonah Anderson; Gorlatov, Sergey; Lerner, Laura, Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use.
Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill Jennifer L. ; Hossainy Syed F. A., Gels for encapsulation of biological materials.
Dawson, George J.; Desai, Suresh M.; Gutierrez, Robin A.; Muerhoff, A. Scott; Prostko, John; Bogdan, M. Felicia; Marohnic, Christopher C., HCV antigen-antibody combination assay and methods and compositions for use therein.
Young, James F.; Johnson, Leslie S.; Huse, William D.; Wu, Herren; Watkins, Jeffry D., High potency recombinant antibodies and method for producing them.
Young, James F.; Johnson, Leslie S.; Huse, William D.; Wu, Herron; Watkins, Jeffrey D., High potency recombinant antibodies and method for producing them.
Michel Vert FR; Suming Li FR; Iliya Rashkov BG; Jose-Luis Espartero-Sanchez ES, Hydrogels containing triblock copolymers, and preparation and use thereof.
Jed Richard Randall ; Christopher Michael Ryan ; James Lunt ; Mark Henry Hartman ; Eric Stanley Hall ; Jeffrey John Kolstad ; David Roy Witzke, Impact modified melt-stable lactide polymer compositions and processes for manufacture thereof.
Randall Jed Richard ; Ryan Christopher Michael ; Lunt James ; Hartman Mark Henry ; Hall Eric Stanley ; Kolstad Jeffrey John ; Witzke David Roy, Impact modified melt-stable lactide polymer compositions and processes for manufacture thereof.
Hubbell,Jeffrey A.; Pathak,Chandrashekhar P.; Sawhney,Amarpreet S.; Desai,Neil P.; Hill,Jennifer L.; Hossainy,Syed F. A., Implantable substrate coated with a macromer having free radical polymerizable substituents.
Magruder Judy A. (Mt. View CA) Eckenhoff ; deceased James B. (late of Los Altos CA by Bonnie J. Eckenhoff ; executrix ) Cortese Richard (Los Gatos CA) Wright Jeremy C. (Los Altos CA) Peery John R. (S, Implantable system for delivery of fluid-sensitive agents to animals.
Magruder Judy A. ; Eckenhoff ; deceased James B. ; Cortese Richard ; Wright Jeremy C. ; Peery John R. ; Pike James B. ; Robinson Urano A. ; Smith Jonathan P. ; Ziemann Lyle E., Implantable system for delivery of fluid-sensitive agents to animals.
Bezwada Rao S. (Whitehouse Station NJ) Arnold Stephen C. (Franklin NJ) Shalaby Shalaby W. (Anderson SC) Williams Bernard L. (Martinsville NJ), Liquid absorbable copolymers for parenteral applications.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D., Macromolecular microparticles and methods of production and use.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
Polson Alan M. ; Swanbom Deryl D. ; Dunn Richard L. ; Cox Charles P. ; Norton Richard L. ; Lowe Bryan K. ; Peterson Kenneth S., Method and composition for treating a bone tissue defect.
Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissue and controlling their r.
Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their.
Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their.
Eckenhoff James B. (Los Altos CA) Magruder Judy A. (Mt. View CA) Cortese Richard (Cupertino CA) Peery John R. (Palo Alto CA) Wright Jeremy C. (Los Altos CA), Method for delivering somatotropin to an animal.
Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor.
Janoff Andrew S. (Yardley PA) Cullis Pieter R. (Vancouver CAX) Bally Marcel B. (Vancouver CAX) Fountain Michael W. (Griggstown NJ) Ginsberg Richard S. (Monroe NJ) Hope Michael J. (Vancouver CAX) Madd, Method of dehydrating liposomes using protective sugars.
Young, James F.; Koenig, Scott; Johnson, Leslie S.; Huse, William D.; Watkins, Jeffrey D., Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment.
Young, James F.; Koenig, Scott; Johnson, Leslie S.; Huse, William D.; Watkins, Jeffrey D.; Wu, Herren, Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment.
Young, James F.; Koenig, Scott; Johnson, Leslie S.; Huse, William D.; Watkins, Jeffrey D.; Wu, Herren, Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment.
Young, James F.; Koenig, Scott; Johnson, Leslie S.; Huse, William D.; Watkins, Jeffrey D.; Wu, Herren, Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment.
David Michael Schertz ; James Hongxue Wang ; Gregory J. Wideman ; William S. Pomplun, Methods of making blend compositions of an unmodified poly vinyl alcohol and a thermoplastic elastomer.
Mueller, Bernhard K., Methods of treating retinal nerve fiber layer degeneration with monoclonal antibodies against a retinal guidance molecule (RGM) protein.
Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
Chandrashekhar P. Pathak ; Shikha P. Barman ; C. Michael Philbrook ; Amarpreet S. Sawhney ; Arthur J. Coury ; Luis Z. Avila ; Mark T. Kieras, Multiblock biodegradable hydrogels for drug delivery and tissue treatment.
Pathak Chandrashekhar P. ; Barman Shikha P. ; Philbrook C. Michael ; Sawhney Amarpreet S. ; Coury Arthur J. ; Avila Luis Z. ; Kieras Mark T., Multiblock biodegradable hydrogels for drug delivery and tissue treatment.
Pathak, Chandrashekhar P.; Barman, Shikha P.; Philbrook, C. Michael; Sawhney, Amarpreet S.; Coury, Arthur J.; Avila, Luis Z.; Kieras, Mark T., Multiblock biodegradable hydrogels for drug delivery and tissue treatment.
Pathak, Chandrashekhar P.; Barman, Shikha P.; Philbrook, C. Michael; Sawhney, Amarpreet S.; Coury, Arthur J.; Avila, Luis Z.; Kieras, Mark T., Multiblock biodegradable hydrogels for drug delivery and tissue treatment.
Magruder Judy A. ; Eckenhoff James B. ; Cortese Richard ; Wright Jeremy C. ; Peery John R. ; Pike James B. ; Robinson Urano A. ; Smith Jonathan P. ; Ziemann Lyle E., Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals.
Eckenhoff ; deceased James B. ; Holladay Leslie A. ; Leonard ; Jr. John Joseph ; Leung Iris K. M. ; Tao Sally A. ; Magruder Judy A. ; Carr John P. ; Wright Jeremy, Peptide/protein suspending formulations.
Eckenhoff ; deceased James B. ; Holladay Leslie A. ; Leonard ; Jr. John Joseph ; Leung Iris K. M. ; Tao Sally A. ; Magruder Judy A. ; Carr John P. ; Wright Jeremy C., Peptide/protein suspending formulations.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill-West Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill Jennifer L., Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill-West Jennifer L., Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill-West Jennifer L., Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell, Jeffrey A.; Pathak, Chandrashekhar P.; Sawhney, Amarpreet S.; Desai, Neil P.; Hill, Jennifer L., Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Sawhney Amarpreet S. ; Enscore David J. ; Goodrich Stephen D. ; Nason William C. ; Yao Fei ; Weaver Douglas ; Jarrett Peter K. ; Coury Arthur J. ; Rudowsky Ronald S. ; Powell Michelle D. ; Avila Luis, Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
Sawhney Amarpreet S. ; Jarrett Peter K. ; Coury Arthur J. ; Rudowsky Ronald S. ; Powell Michelle D. ; Avila Luis Z. ; Enscore David J. ; Goodrich Stephen D. ; Nason William C. ; Yao Fei ; Weaver Doug, Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
Brown Gregory L. (Atlanta GA) Eiferman Richard (Louisville KY) Schultz Gregory L. (Louisville KY) Valenzuela ; Pablo D. T. (San Francisco CA), Promotion of corneal stroma wound healing with human epidermal growth factor prepared from recombinant DNA.
Cha Younsik (Salt Lake City UT) Choi Young Kweon (Salt Lake City UT) Bae You Han (Kwangju KRX), Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers.
Jeffrey A. Hubbell CH; Chandrashekhar P. Pathak ; Amarpreet Sawhney ; Neil Desai ; Syed Hossainy ; Jennifer L. Hill-West, Treating medical conditions by polymerizing macromers to form polymeric materials.
Mueller, Bernhard K.; Macchi, Paolo; Bonhoeffer, Friedrich; Stahl, Bernd; Mann, Matthias; Andersen, Jens S.; Monnier, Philippe P., Use of RGM and its modulators.
Wang, James H.; Schertz, David M., Water-responsive, biodegradable compositions and films and articles comprising a blend of polylactide and polyvinyl alcohol and methods for making the same.
Wang James Hongxue ; Schertz David Michael ; Soerens Dave Allen ; Rhim Hannong, Water-responsive, biodegradable fibers comprising polylactide modified polylactide and polyvinyl alcohol, and method fo.
Wang James Hongxue ; Schertz David Michael ; Soerens Dave Allen, Water-responsive, biodegradable film compositions comprising polylactide and polyvinyl alcohol, and a method for making the films.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.