초록 ▼

An electrospray ion source for a mass spectrometer capable of generating ions from samples dissolved in a solution comprises a capillary tube through which the said solution is pumped into a first chamber maintained substantially at atmospheric pressure and in which an inert gas is flowing in a dire

An electrospray ion source for a mass spectrometer capable of generating ions from samples dissolved in a solution comprises a capillary tube through which the said solution is pumped into a first chamber maintained substantially at atmospheric pressure and in which an inert gas is flowing in a direction counter to the flow of the solution, and a small orifice in the end wall of the chamber opposite to and aligned with the capillary. A high potential difference is applied between the capillary and the end wall so that the solution is electrosprayed into the chamber and ions characteristic of the sample are formed. These ions are desolvated to a controllable extent by the inert gas, which may also be heated to improve the efficiency of the process and increase the maximum permissible flow rate of solution. The ions so formed pass through the small orifice into a second chamber maintained at a reduced pressure, and into a mass spectrometer. Alternatively an additional pressure reduction stage can be included, so that the ions pass into a third chamber maintained at a still lower pressure in which the mass spectrometer is situated through a conventional nozzle and skimmer arrangement. The ion source is particularly effective for the production of unfragmented and unsolvated ions from thermally unstable or involatile samples, and may be used as a liquid chromatograph－mass spectrometer interface.

대표청구항 ▼

In a method of generating ions for mass spectral analysis from a sample dissolved in a solution by electrospray ionization the improvement comprising: (a) causing said solution to flow through a capillary tube or jet; (b) maintaining a high electrical potential difference between said capillary tube

In a method of generating ions for mass spectral analysis from a sample dissolved in a solution by electrospray ionization the improvement comprising: (a) causing said solution to flow through a capillary tube or jet; (b) maintaining a high electrical potential difference between said capillary tube or jet and a first conductive wall spaced from and disposed facing the outlet of said capillary tube or jet thereby causing said solution to be electrosprayed from said outlet; (c) maintaining the ambient pressure between said outlet and said wall at substantially atmospheric pressure; (d) providing between said wall and said outlet a flow of inert gas substantially counter to the flow from said outlet; (e) providing an orifice in said wall in alignment with the axis of said capillary tube or jet at the outlet thereof; and (f) maintaining the pressure on the side of said wall remote from said outlet at a reduced pressure whereby gas containing ions from said solution characteristic of said sample flows through said orifice.