초록 ▼

A dosage inhalator for the inhalation of a pharmacologically active compound in solid, micronized form is disclosed. The inhalator comprises a propellant container, a propellant dispensing unit, and a dosing unit for dosing the pharmacologically active compound. The dosing unit comprises a storage c

A dosage inhalator for the inhalation of a pharmacologically active compound in solid, micronized form is disclosed. The inhalator comprises a propellant container, a propellant dispensing unit, and a dosing unit for dosing the pharmacologically active compound. The dosing unit comprises a storage chamber for the active compound, a dose loading unit directly connected thereto, and a nozzle. The dose loading unit comprises a movable perforated membrane, and a holder for the perforated membrane. The membrane is displaceable between a first position where active compound is introduced into the perforations of the membrane, and second position where the perforations of the membrane are inserted into a propellant passage. While the membrane is in the second position, the propellant dispensing unit may be operated, allowing propellant originally stored in the propellant container to remove the active compound from the perforations inserted into the propellant passage and carry said compound out the nozzle.

대표청구항 ▼

An inhaler for administering to a patient a pharmacologically active solid in a dry micronized powder having a particle size of less than 5 micrometers suspended in a propellant comprising: a gas conduit through which a dose of said solid suspended in said propellant is supplied to said patient, a s

An inhaler for administering to a patient a pharmacologically active solid in a dry micronized powder having a particle size of less than 5 micrometers suspended in a propellant comprising: a gas conduit through which a dose of said solid suspended in said propellant is supplied to said patient, a storage chamber for said solid, a perforated membrane having a plurality of preselected portions each adapted to hold and dispense a reproducible unit dose less than 50 mg of said solid, and a propellant supply unit for supplying a pharmacologically acceptable propellant to the inhaler, said conduit, membrane and propellant supply unit being operably connected to each other so that propellant released from the propellant supply unit passes through one of said preselected portions of said perforated membrane that is positioned across said gas conduit, releases said solid carried thereby, and carries said solid as a suspended solid through said gas conduit to the patient, wherein said perforated membrane is adapted to be displaceable through a plurality of positions in each of which another preselected portion thereof holding a reproducible dose of said solid is moved into a dispensing position relative to said gas conduit and propellant supply unit, and another portion thereof is moved into said storage chamber, and wherein said chamber includes means operably disposed relative to the position of said perforated membrane in said storage chamber for introducing said reproducible amount of said active solid into the perforations of said membrane, whereby reproducible doses of the solid can be transferred from said storage chamber by said membrane, positioned across said gas conduit by said membrane, and removed therefrom by propellant discharged from said propellant supply unit.