[특허]DHEA Formulations and methods for treating dry skin

DHEA Formulations and methods for treating dry skin 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-031/56
출원번호	US-0694537 (1985-01-24)
발명자 / 주소	Orentreich, Norman
대리인 / 주소	Panitch, Schwarze, Jacobs & Nadel
인용정보	피인용 횟수 : 62 인용 특허 : 0

초록 ▼

Topical formulations for treating dry skin with dehydroepiandrosterone (DHEA) may contain a keratolytic agent to counteract the formation of acne-like skin lesions without diminishing the effectiveness of DHEA in increasing sebum production. The keratolytic agent may be a hydroxybenzoic acid, alpha-hydroxycarboxylic acid or urea, with salicylic acid being preferred. The DHEA and keratolytic agent may be formulated in a non-toxic, dermatologically acceptable vehicle including tinctures, creams, ointments, gels and lotions.

대표청구항 ▼

1. A topical composition for treating dry skin in a patient comprising: a. dehydroepiandrosterone and/or a pharmaceutically acceptable, therapeutically effective derivative thereof in an amount effective to increase sebum production; b. a keratolytic agent in an amount sufficient to counteract the formation of acne-like skin lesions without diminishing the effectineness of dehydroepiandrosterone or its derivative; and c. a non-toxic, dermatologically acceptable vehicle. 2. A composition according to claim 1 wherein said keratolytic agent is selected from the group consisting of hydroxybenzoic acids, alpha-hydroxycarboxylic acids and urea. 3. A composition according to claim 2 wherein said alpha-hydroxycarboxylic acid is selected from the group consisting of glycolic, tartaric, lactic and mandelic acids. 4. A composition according to claim 3 wherein said keratolytic agent is present in an amount of about 0.1 to 10 weight percent of the composition. 5. A composition according to claim 2 wherein said keratolytic agent is salicylic acid. 6. A composition according to claim 5 wherein said salicylic acid is present in an amount of about 0.1 to 2 weight percent of the composition. 7. A composition according to claim 1 wherein said dehydroepiandrosterone and/or derivative thereof is present in an amount of about 0.01 to 1.0 weight percent of the composition. 8. A composition according to claim 1 wherein dehydroepiandrosterone free alcohol is present in an amount of about 1.0 weight percent and said keratolytic agent is salicylic acid present in an amount of about 1.0 weight percent of the composition. 9. A composition according to claim 1 wherein said vehicle is selected from the group consisting of tinctures, creams, ointments, gels and lotions. 10. A method of treating dry skin in a patient which comprises topically administering to the area of dry skin in the patient a composition comprising (a) an effective amount of dehydroepiandrosterone and/or a pharmaceutically acceptable, therapeutically effective derivative thereof and (b) a keratolytic agent in an amount sufficient to counteract the formation of acne-like skin lesions without diminishing the effectiveness of dehydroepiandrosterone or its derivative. 11. A method according to claim 10 wherein said keratolytic agent is salicylic acid. 12. A method according to claim 10 wherein said salicylic acid comprises about 0.1 to 2 weight percent of said composition. 13. A method according to claim 10 wherein said keratolytic agent is an alpha-hydroxycarboxylic acid in an amount of about 0.1 to 10 weight percent of the composition. 14. A method according to claim 10 wherein said patient has a genetic tendency for acne. 15. A method according to claim 10 wherein said composition contains about 0.01 to 1 weight percent dehydroepiandrosterone and/or derivative thereof. 16. A method according to claim 10 wherein said composition is administered in a non-toxic, dermatologically acceptable vehicle selected from the group consisting of tinctures, creams, ointments, gels and lotions.

이 특허를 인용한 특허 (62)

Gubernick Joseph ; Maes Daniel H., .alpha.-hydroxyacid esters of DHEA useful against skin disorders.
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Briggs Gillian Scott,GBX ; Crook Teresa Barbara,GBX ; Smith Graeme Douglas T.,GBX, Anti-acne cosmetic compositions.
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Zeligs Michael A., Combined dehydroepiandrosterone and retinoid therapy for epithelial disorders.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulating skin wrinkles and or skin atrophy.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulating skin wrinkles and/or skin athropy.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie ; Doughty Darrell Gene ; Linares Carlos Gabriel, Compositions for regulations skin wrinkles and/or skin atrophy.
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France Baldo FR; Susanne Dreher FR, Cosmetic composition containing a steroid and a 2-alkylalkanol or an ester thereof.
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Breton Lionel,FRX ; De Lacharriere Olivier,FRX, Cosmetic/dermatological skin care compositions comprising S-DHEA.
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Breton Lionel,FRX ; de Lacharriere Olivier,FRX, Cosmetic/dermatological skin care compositions comprising S-DHEA.
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Riepl, Michael S., DHEA bioadhesive controlled release gel.
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Gubernick Joseph ; Maes Daniel H., Dehydroep:androsterone sailcylate useful against skin atrophy.
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Roberts Eugene (Monrovia CA), Dehydroepiandrosterone therapy for ameleoration of prostate hypertrophy and sexual dysfunction.
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Fernand Labrie CA, Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors.
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Labrie, Fernand, Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors.
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Labrie, Fernand, Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors.
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Labrie, Fernand, Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors.
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Labrie, Fernand, Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors.
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Labrie,Fernand, Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors.
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Ronald J. Zenk ; John L. Zenk, Method for diminishing wrinkles and fine lines of the skin by the topical application of .DELTA.5-androstene-3.beta.-ol-7, 17 dione and metabolizable precursors thereof.
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Ronald J. Zenk ; John L. Zenk, Method of moisturizing the skin by the topical application of .DELTA.5-androstene-3.beta.-ol-7,17 dione and metabolizable precursors thereof.
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Walser Mackenzie (Ruxton MD), Method of retarding the progression of chronic renal failure.
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Labrie Fernand,CAX, Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone.
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Daynes Raymond A. ; Araneo Barbara A., Methods for augmenting immunological responses through the administration of dehydroepiandrosterone (DHEA) and dehydroe.
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White, Hillary D.; Gyurik, Robert, Methods for the treatment of fibromyalgia and chronic fatigue syndrome.
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White, Hillary D., Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein.
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White, Hillary D., Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein.
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Blank Roy L. (Spring Valley NY), Salicylic acid for regulating skin wrinkles and/or skin atrophy.
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O\Laughlin Richard L. (North Brunswick NJ) Panaggio Andrea (Jamesburg NJ) Varia Sailesh A. (Plainsboro NJ), Steroid cream formulation.
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Gubernick Joseph ; Maes Daniel H., Steroid esters useful against skin disorders.
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Maes Daniel H. (Huntington NY) Zecchino Jules (Closter NJ) Knight Althea (Teaneck NJ), Sulfur-based amides and bis-amides useful against skin disorders.
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Maes Daniel H. ; Zecchino Jules ; Knight Althea, Sulfur-based amides and bis-amides useful against skin disorders.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Labrie Fernand,CAX, Therapeutic methods and delivery systems utilizing sex steroid precursors.
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Shaak Carolyn V., Transdermal application of naturally occurring steroid hormones.
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White, Hillary D.; Gyurik, Robert, Transdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome.
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White, Hillary D.; Gyurik, Robert, Transdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome.
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Hsia Sung L. (Miami FL) Voigt Walter (Miami FL) Sawaya Marty (Miami FL) Zeoli Kathryn (Miami FL), Treatment of skin over androgenicity using compositions containing pregnenolone.
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De Lacharriere,Olivier; Nouveau,Stephanie, Use of DHEA or precursors or metabolic derivatives thereof as a depigmenting agent.
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Blank Roy Lonnie, Use of salicyclic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie (Spring Valley NY), Use of salicyclic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie (Spring Valley NY), Use of salicyclic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy L. (Spring Valley NY), Use of salicylic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy L. (Spring Valley NY), Use of salicylic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie, Use of salicylic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie, Use of salicylic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie, Use of salicylic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie, Use of salicylic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie, Use of salicylic acid for regulating skin wrinkles and/or skin atrophy.
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Blank Roy Lonnie (Spring Valley NY), Use of salicylic acid for regulating skin wrinkles and/or skin atrophy.
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DHEA Formulations and methods for treating dry skin 원문보기

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DHEA Formulations and methods for treating dry skin 원문보기

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연구과제 타임라인

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이 특허를 인용한 특허 (62)

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