Method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid
IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0482259
(1983-04-05)
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우선권정보 |
JP-0061237 (1982-04-12); JP-0002600 (1983-01-10); JP-0006348 (1983-01-17); JP-0020982 (1983-02-09) |
발명자
/ 주소 |
- Minai, Masayoshi
- Katsura, Tadashi
- Hamada, Kazuhiko
- Suzukamo, Gohfu
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출원인 / 주소 |
- Sumitomo Chemical Company, Limited
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대리인 / 주소 |
Stevens, Davis, Miller & Mosher
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인용정보 |
피인용 횟수 :
3 인용 특허 :
3 |
초록
▼
A method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid useful as an intermediate for dehydropeptidase I inhibitors, medicines and agricultural chemicals, which comprises reacting an optically active diphenylethylamine represented by the formula, ##STR## wherein R 1 and R
A method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid useful as an intermediate for dehydropeptidase I inhibitors, medicines and agricultural chemicals, which comprises reacting an optically active diphenylethylamine represented by the formula, ##STR## wherein R 1 and R 2 are each a hydrogen atom or a lower alkyl group, with 2,2-dimethylcyclopropanecarboxylic acid in a solvent to achieve the optical purification of said acid.
대표청구항
▼
1. A method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid which comprises reacting an optically active diphenylethylamine represented by the formula (I), ##STR## wherein R 1 and R 2 are each a hydrogen atom or a lower alkyl group, with 2,2-dimethylcyclopropanecarboxylic a
1. A method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid which comprises reacting an optically active diphenylethylamine represented by the formula (I), ##STR## wherein R 1 and R 2 are each a hydrogen atom or a lower alkyl group, with 2,2-dimethylcyclopropanecarboxylic acid in a solvent to achieve the optical purification of said acid. 2. A method as described in claim 1, wherein said 2,2-dimethylcyclopropanecarboxylic acid is a one containing the d-form in excess, and said optically active 2,2-dimethylcyclopropanecarboxylic acid is d-2,2-dimethylcyclopropanecarboxylic acid. 3. A method as described in claim 1, wherein said 2,2-dimethylcyclopropanecarboxylic acid is a one containing the l-form in excess, and said optically active 2,2-dimethylcyclopropanecarboxylic acid is l-2,2-dimethylcyclopropanecarboxylic acid. 4. A method as described in claim 2, wherein the optical excess rate of said 2,2-dimethylcyclopropanecarboxylic acid is not less than 30%. 5. A method as described in claim 1, wherein said optically active diphenylethylamine is either of d- or l-α-phenyl-β-(p-tolyl)ethylamine, d- or l-α-(p-tolyl)-β-phenylethylamine or d- or l-α-phenyl-β-phenylethylamine. 6. A method as described in claim 1, wherein the amount of the optically active diphenylethylamine used is 0.3 to 1.2 times by mole based on 2,2-dimethylcyclopropanecarboxylic acid, a starting material. 7. A method as described in claim 3, wherein the optical excess rate of said 2,2-dimethylcyclopropanecarboxylic acid is not less than 30%.
이 특허에 인용된 특허 (3)
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Pavan Charles (Nogent-sur-Marne FRX) Bulidon Jacques (Paris FRX), Resolution process using L or D N-methyl-ephedrine.
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Naumann Klaus (Cologne DEX), Separation of enantiomers of chiral carboxylic acids.
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Naumann Klaus (Cologne DEX), Separation of stereoisomeric vinylcyclopropanecarboxylic acids.
이 특허를 인용한 특허 (3)
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McConchie Sr. Noel P. (6875 Hitchcock Rd. Milford MI 48042), Diagnostic test apparatus for electrical system of automotive vehicle.
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Chen Bang-Chi ; Sundeen Joseph E. ; North Jeffrey T. ; Pullockaran Annie J. ; Ahmad Saleem ; Wu Shung C. ; Atwal Karnail S. ; Dugar Sundeep, Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines.
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Nohira Hiroyuki (Urawa JPX) Yoshida Shinichi (Misato JPX), Process for the optical resolution of (±)-cis or (±)-trans-permethric acid.
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