Methods for the treatment and prophylaxis of diaper rash and diaper dermatitis
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-033/24
A61K-033/30
출원번호
US-0460692
(1983-01-24)
발명자
/ 주소
Buckingham, Kent W.
출원인 / 주소
The Procter & Gamble Company
대리인 / 주소
Allen, George W.Schaeffer, Jack D.Goldstein, Steven J.
인용정보
피인용 횟수 :
107인용 특허 :
6
초록▼
Methods for the treatment and prevention of diaper rash and diaper dermatitis caused by the prolonged contact of human skin with body waste are disclosed. The methods of the present invention employ the topical application of a minimum inhibitory concentration of a pharmaceutically-acceptable lipase
Methods for the treatment and prevention of diaper rash and diaper dermatitis caused by the prolonged contact of human skin with body waste are disclosed. The methods of the present invention employ the topical application of a minimum inhibitory concentration of a pharmaceutically-acceptable lipase-inhibiting agent to the area in need of such treatment, or the area where prevention is desired. The lipase-inhibiting agent is preferably a water-soluble metallic salt, such as ZnCl 2, and is preferably applied in combination with a barrier-like vehicle. The effectiveness of these methods is surprising in light of the present confusion and controversy surrounding the actual causes of diaper rash, and the heretofore unrecognized role of lipase as a factor in the cause of diaper rash and diaper dermatitis.
대표청구항▼
1. A method of treating and preventing diaper rash, or diaper dermatitis, caused by prolonged contact of human skin with body waste, which method comprises topically applying to an area in need of such treatment or prevention a minimum inhibitory concentration of a pharmaceutically-acceptable lipase
1. A method of treating and preventing diaper rash, or diaper dermatitis, caused by prolonged contact of human skin with body waste, which method comprises topically applying to an area in need of such treatment or prevention a minimum inhibitory concentration of a pharmaceutically-acceptable lipase-inhibiting agent selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron. 2. A method according to claim 1 wherein the lipase-inhibiting agent is selected from the group consisting of the water-soluble salts of cobalt, lanthanum, tin, zinc, iron, and mixtures thereof. 3. A method according to claim 2 wherein the lipase-inhibiting agent is selected from the group consisting of zinc chloride, zinc acetate, zinc nitrate trihydrate, zinc nitrate hexahydrate, zinc sulfate, zinc sulfate heptahydrate, zinc sulfate hexahydrate, iron(II)chloride, iron(II)chloride tetrahydrate, iron(III)chloride, iron(III)chloride monohydrate, iron(III)chloride hexahydrate, iron(II)lactate, iron(III)lactate, iron(III)malate, iron(II)nitrate, iron(III)nitrate hexahydrate, iron(III)nitrate.9H 2 O, iron(II)sulfate and its hydrates, iron(III)sulfate and its hydrates, tin chloride, cobalt chloride and lanthanum chloride. 4. A method according to claim 2 wherein the lipase-inhibiting agent is selected from the zinc salts of the monocarboxylic fatty acids having from about 6 to about 12 carbon atoms. 5. A method according to claim 4 wherein the zinc salt of the monocarboxylic fatty acid has from about 8 to about 10 carbon atoms. 6. A method according to claim 3 wherein the lipase-inhibiting agent is selected from the group consisting of zinc chloride, zinc sulfate, iron(II)chloride, iron(III)chloride, tin chloride, and mixtures thereof. 7. A method according to claim 6 wherein the lipase-inhibiting agent is zinc chloride. 8. A method according to claim 2 wherein the lipase-inhibiting agent is applied at a concentration of about 10 mM or greater. 9. A method according to claim 3 wherein the lipase-inhibiting agent is applied at a concentration of about 10 mM or greater. 10. A method according to claim 6 wherein the lipase-inhibiting agent is applied at a concentration of about 10 mM or greater. 11. A method according to claim 7 wherein the lipase-inhibiting agent is applied at a concentration of about 10 mM or greater. 12. A method according to claim 2 wherein the lipase-inhibiting agent is applied at a concentration of about 50 mM or greater. 13. A method according to claim 3 wherein the lipase-inhibiting agent is applied at a concentration of about 50 mM or greater. 14. A method according to claim 6 wherein the lipase-inhibiting agent is applied at a concentration of about 50 mM or greater. 15. A method according to claim 11 wherein the lipase-inhibiting agent is applied at a concentration of about 50 mM or greater. 16. A method according to claim 2 wherein the lipase-inhibiting agent is applied at a concentration of about 100 mM or greater. 17. A method according to claim 3 wherein the lipase-inhibiting agent is applied at a concentration of about 100 mM or greater. 18. A method according to claim 6 wherein the lipase-inhibiting agent is applied at a concentration of about 100 mM or greater. 19. A method according to claim 11 wherein the lipase-inhibiting agent is applied at a concentration of about 100 mM or greater. 20. In a disposable diaper comprising: (1) an absorbent core, (2) a topsheet, said topsheet superposed or co-extensive with one face of said core, and (3) a liquid impervious backsheet, said backsheet superposed or co-extensive with the face of said core opposite the face covered by said topsheet; the improvement comprising incorporating therein a lipase-inhibiting agent at its minimum inhibitory concentration or greater, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron. 21. An article according to claim 20 wherein the lipase-inhibiting agent is incorporated into the absorbent core. 22. An article according to claim 20 wherein the lipase-inhibiting agent is incorporated into the topsheet. 23. In a disposable wipe especially adapted for removing fecal matter from skin comprising: an absorbent fibrous material; the improvement comprising releasably incorporating into said absorbent material an amount of lipase-inhibiting agent sufficient to deliver a minimum inhibitory concentration of said agent to human skin when used to remove fecal matter, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron. 24. In a disposable wipe especially adapted for removing fecal matter from skin comprising: (1) an absorbent fibrous material; and (2) a feces-impermeable backing, said backing superposed or at least partially co-extensive with one face of said absorbent material; the improvement comprising releasably incorporating into said absorbent material an amount of lipase-inhibiting agent sufficient to deliver a minimum inhibitory concentration of said agent to human skin when used to remove fecal matter, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron. 25. An article according to claim 24 wherein the absorbent material has additionally releasably incorporated therein a safe and effective amount of skin cleansing agent. 26. An article according to claim 25 wherein the cleansing agent is an oleaginous cleansing agent. 27. A method of treating and preventing diaper rash, or diaper dermatitis, caused by prolonged contact of human skin with body waste comprising contacting the area in need of such treatment with an article according to claim 23.
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